在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RABGEF1 Antibody

  • 中文名稱:
    RABGEF1兔多克隆抗體
  • 貨號:
    CSB-PA883453LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA883453LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA883453LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RABGEF1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    RABGEF1
  • 別名:
    RAB guanine nucleotide exchange factor (GEF) 1 antibody; Rab5 GDP/GTP exchange factor antibody; Rab5ef antibody; Rabaptin 5 associated exchange factor for Rab5 antibody; Rabaptin-5-associated exchange factor for Rab5 antibody; Rabex 5 antibody; Rabex-5 antibody; RABGEF 1 antibody; Rabgef1 antibody; RABX 5 antibody; RABX5 antibody; RABX5_HUMAN antibody; RAP1 antibody; Rin 2 antibody; Rin2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Rab5 GDP/GTP exchange factor protein (1-491AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,RABGEF1 Antibody (CSB-PA883453LA01HU),的標記方式是Non-conjugated。對于RABGEF1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA883453LB01HU RABGEF1 Antibody, HRP conjugated ELISA
    FITC CSB-PA883453LC01HU RABGEF1 Antibody, FITC conjugated
    Biotin CSB-PA883453LD01HU RABGEF1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.
  • 基因功能參考文獻:
    1. The authors demonstrate that RABGEF1, the upstream factor of the endosomal Rab GTPase cascade, is recruited to damaged mitochondria via ubiquitin binding downstream of Parkin. RABGEF1 directs the downstream Rab proteins, RAB5 and RAB7A, to damaged mitochondria, whose associations are further regulated by mitochondrial Rab-GAPs. PMID: 29360040
    2. RABEX-5 mRNA expression was significantly upregulated in colorectal cancer tissues. PMID: 28617553
    3. we identify Rabex-5 as a Immunomodulatory drugs (IMiDs) target molecule that functions to restrain TLR activated auto-immune promoting pathways. We propose that release of Rabex-5 from complex with Cereblon enables the suppression of immune responses, contributing to the antiinflammatory properties of IMiDs. PMID: 27601648
    4. findings reveal a key role for RABGEF1 in dampening keratinocyte-intrinsic MYD88 signaling and sustaining epidermal barrier function PMID: 27820702
    5. The results contradict the model of feedback activation of Rab5 and instead indicate that Rbpt5 is recruited by both Rabex5 recognizing ubiquitylated cargo and by Rab4 to activate Rab5 in a feed-forward manner. PMID: 26430212
    6. RABEX-5 is a potential useful indicator and predicts a poor long-term prognosis for small cell lung cancer(SCLC), which should be considered in defining the prognosis with other well-known prognosticators in C-SCLC patients PMID: 26002576
    7. Expression of RABEX-5 is significantly higher in gastric cancer tissues and is associated with tumor size and lymph node metastasis. PMID: 25427001
    8. analysis of Rabex-5 GEF activation by Rabaptin-5 PMID: 24957337
    9. This implies that Rap regulates endothelial barrier function by dual control of cytoskeletal tension. The molecular details of the signaling pathways are becoming to be elucidated PMID: 24714377
    10. RABEX-5 mRNA expression is a strong predictor of poor prognosis in prostate cancer patients treated by radical prostatectomy. PMID: 24716822
    11. Interaction of Rabex-5 with Rab5 depends on interaction of the MIU domain with the ubiquitinated L1 to drive its internalization. PMID: 23048039
    12. KCa2.3 is localized to a caveolin-rich domain within the plasma membrane and is endocytosed in a dynamin- and Rab5-dependent manner. PMID: 22952906
    13. a novel mechanistic insight into how Rabex-5 regulates internalization and postendocytic trafficking of ubiquitinated L1 destined for lysosomal degradation. PMID: 22846990
    14. RABEX-5 and RAB5 may be involved in the development of breast cancer metastasis. PMID: 21500550
    15. functions as an E3 ligase for Ras PMID: 20655225
    16. GGAs, a family of Arf-dependent clathrin adaptors involved in selection of TGN cargo, interact with the Rabaptin-5-Rabex-5 complex, a Rab4/Rab5 effector regulating endosome fusion PMID: 12505986
    17. Here, we report that Rabex-5, a guanine nucleotide exchange factor for Rab5, binds to ubiquitin through two independent ubiquitin binding domains PMID: 16499958
    18. Fc epsilon RI-mediated mast cell functional activation is dependent on RabGEF1's GEF activity PMID: 17341663
    19. crystal structure of the RABEX-5 catalytic core in complex with nucleotide-free RAB21, a key intermediate in the exchange reaction pathway PMID: 17450153
    20. Integration of TGFB and RAS signaling silences RABGEF1 and enhances growth factor-directed cell migration. PMID: 18160707

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Early endosome. Recycling endosome.
  • 數據庫鏈接:

    HGNC: 17676

    OMIM: 609700

    KEGG: hsa:27342

    UniGene: Hs.530053



主站蜘蛛池模板: 99精品视频在线观看免费| 欧美人禽杂交狂配免费看| 中文字字幕乱码视频高清| 国产v在线在线观看视频免费| 精品国产av 无码一区二区三区 | 亚洲—本道 在线无码av发| 日本 精品 高清不卡| 国产二级一片内射视频插放| 无码国产乱人伦偷精品视频| 日韩卡1卡2 卡三卡免费| 国产两女互慰高潮视频在线观看 | 任我撸在线视频| 日本又色又爽又黄的视频免 | 乱人伦人妻中文字幕无码久久网| 国产色产综合色产在线视频 | 免费裸体黄网站18禁免费 | 男女猛烈无遮挡免费视频| 国产精品99久久免费| 国产一卡2卡3卡4卡精品| 国产精品久久久久aaaa| 亚洲日韩av一区二区三区四区| 久久精品亚洲男人的天堂| 色综合无码av网站| 狂野欧美性猛交xxxx| 亚洲va久久久噜噜噜久久天堂| 亚洲精品国产自在久久| 久久亚洲国产成人精品性色| 国产精品视频免费播放| 2020精品自拍视频曝光| 在线观看片免费人成视频无码| 欧美丰满少妇xxxxx| 色五月丁香五月综合五月4438| 久久天天躁夜夜躁狠狠85| 色综合天天综合网国产成人网| 美女又黄又免费的视频| 国产精品国语对白露脸在线播放 | 色视频www在线播放国产人成| 曰韩免费无码av一区二区| 日本免码va在线看免费| 亚洲国产精品无码久久久不卡| 狠狠色狠狠色综合日日不卡|