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RAB7B Antibody

  • 中文名稱：
    RAB7B兔多克隆抗體
  • 貨號：
    CSB-PA019220LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of Hela cells with CSB-PA019220LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RAB7B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    MGC16212 antibody; MGC9726 antibody; RAB7 antibody; rab7B antibody; RAB7B; member RAS oncogene family antibody; RAB7B_HUMAN antibody; Ras related protein Rab 7b antibody; Ras-related protein Rab-7B antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ras-related protein Rab-7b protein (100-199AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，RAB7B Antibody (CSB-PA019220LA01HU)，的標記方式是Non-conjugated。對于RAB7B Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA019220LB01HU RAB7B Antibody, HRP conjugated ELISA
    FITC CSB-PA019220LC01HU RAB7B Antibody, FITC conjugated
    Biotin CSB-PA019220LD01HU RAB7B Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
  • 基因功能參考文獻：
    1. study demonstrates that Rab7b regulates LC3 processing by modulating Atg4B activity; taken together, findings reveal Rab7b as a novel negative regulator of autophagy through its interaction with Atg4B PMID: 28835545
    2. Authors determined the effects of T. suis soluble products (SPs) on Toll-like receptor-4 (TLR4)- In addition, T. suis SPs induce Rab7b, a negative regulator of TLR4 signalling PMID: 25996526
    3. Rab9a and Rab7b are mediators of the transit of the L2 capsid protien and the pseudogenome of human papillomavirus 16 from the late endosome to the golgi complex. PMID: 23345514
    4. Rab7b is required for sortilin transport from endosomes to the TGN. PMID: 22708738
    5. Rab7b may play important roles in megakaryopoiesis by activating NF-kappaB and promoting IL-6 production. PMID: 20953574
    6. Rab7b is required for normal lysosome function, and, in particular, it is an essential factor for retrograde transport from endosomes to the trans-Golgi network. PMID: 20375062

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  • 亞細胞定位：
    Late endosome. Lysosome. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 組織特異性：
    Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.
  • 數據庫鏈接：

    HGNC: 30513

    KEGG: hsa:338382

    UniGene: Hs.534612



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