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RAB3GAP2 Antibody

  • 中文名稱：
    RAB3GAP2兔多克隆抗體
  • 貨號：
    CSB-PA215524
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from COS cells, using RAB3GAP2 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using RAB3GAP2 antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RAB3GAP2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RAB3GAP2
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
  • 基因功能參考文獻：
    1. functionally severe RAB3GAP2 mutations cause Warburg Micro syndrome while hypomorphic RAB3GAP2 mutations can result in the milder Martsolf phenotype PMID: 20967465
    2. Data show that at chemical synapses, Rab3 performs specific functions in synpatic vesicle exocytosis. PMID: 18485483
    3. KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator RAB3GAP2 occurs in a GTP-dependent manner through MADD. PMID: 18849981
  • 相關疾病：
    Martsolf syndrome (MARTS); Warburg micro syndrome 2 (WARBM2)
  • 亞細胞定位：
    Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction.
  • 蛋白家族：
    Rab3-GAP regulatory subunit family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 17168

    OMIM: 212720

    KEGG: hsa:25782

    STRING: 9606.ENSP00000351832

    UniGene: Hs.654849



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