在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RAB39B Antibody

  • 中文名稱:
    RAB39B兔多克隆抗體
  • 貨號:
    CSB-PA822194LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA822194LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA822194LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA822194LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RAB39B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    RAB39B
  • 別名:
    RAB39B antibody; Ras-related protein Rab-39B antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Ras-related protein Rab-39B protein (1-213AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,RAB39B Antibody (CSB-PA822194LA01HU),的標記方式是Non-conjugated。對于RAB39B Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA822194LB01HU RAB39B Antibody, HRP conjugated ELISA
    FITC CSB-PA822194LC01HU RAB39B Antibody, FITC conjugated
    Biotin CSB-PA822194LD01HU RAB39B Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Small GTPases Rab involved in autophagy. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission.
  • 基因功能參考文獻:
    1. we report on two novel RAB39B frameshift variants associated with X-linked Parkinsonism associated with Intellectual Disability and we also describe, for the first time, a somatic mosaicism in a patient carrying RAB39B mutation PMID: 28851564
    2. results suggest that RAB39B mutation is very rare in familial PD and may not be a major cause of familial PD in the Chinese Han Population PMID: 27694831
    3. This study identified two patients carrying a variant in RAB39B out of 344 male patients with Parkinsonsim. PMID: 27448726
    4. Direct sequencing analysis of all coding exons and exon-intron boundaries was performed to detect small sequence alterations in RAB39B gene PMID: 27036214
    5. penetrance for autism spectrum disorder is high among males but more variable among females with RAB39B mutations; a critical role for this gene in brain development and function is demonstrated PMID: 29152164
    6. X-linked juvenile parkinsonism could be caused by a RAB39B mutation, and basal ganglia calcification may be a novel clinical feature of RAB39B-related parkinsonism. PMID: 27943471
    7. RAB39B mutations are not a common cause of Parkinson's disease or dementia with Lewy bodies in Caucasian population PMID: 27459931
    8. RAB39B mutations are not a common cause of early-onset or familial PD in our Taiwanese population. PMID: 27838047
    9. RAB39B mutations are a rare finding in Parkinson disease patients PMID: 26739247
    10. RAB39B is an essential regulator of vesicular-trafficking in clinically typical Parkinson's disease PMID: 26399558
    11. It plays little or no role in the development of PD in Chinese population. PMID: 26163985
    12. RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition PMID: 25784538
    13. The loss of RAB39B results in dysregulation of alpha-synuclein homeostasis and a spectrum of neuropathological features that implicate RAB39B in the pathogenesis of Parkinson disease and potentially other neurodegenerative disorders. PMID: 25434005
    14. increased dosage of RAB39B causes a disturbed neuronal development leading to cognitive impairment PMID: 24357492
    15. Data indicate that myosin Va interacted with multiple new Rab subfamilies including Rab6, Rab14 and Rab39B. PMID: 24006491
    16. These results demonstrate developmental and functional neuronal alteration as a consequence of downregulation of RAB39B and emphasize the critical role of vesicular trafficking in the development of neurons and human intellectual abilities. PMID: 20159109
    17. RAB39B was expressed in a variety of human tissues and located in human chromosome Xq28. PMID: 12438742

    顯示更多

    收起更多

  • 相關疾病:
    Mental retardation, X-linked 72 (MRX72); Waisman syndrome (WSMN)
  • 亞細胞定位:
    Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus.
  • 蛋白家族:
    Small GTPase superfamily, Rab family
  • 組織特異性:
    Highly expressed in the brain.
  • 數據庫鏈接:

    HGNC: 16499

    OMIM: 300271

    KEGG: hsa:116442

    STRING: 9606.ENSP00000358466

    UniGene: Hs.632832



主站蜘蛛池模板: 朝鲜女人大白屁股ass| 亚洲日韩一区二区| 日韩精品久久无码人妻中文字幕| 国产精品久久久久9999爆乳| www插插插无码视频网站| 麻豆视传媒精品av| 日本高清二区视频久二区| 欧美三级在线播放| 国产麻豆剧传媒精品av| 亚洲乱码日产一区三区| 亚洲精品无码伊人久久| 国产亚洲欧美精品永久| 亚洲精品一区二区三区蜜臀| 国产成人一区二区精品视频 | 亚洲国产成人久久精品99| 特黄熟妇丰满人妻无码| 国产精品186在线观看在线播放| 成 人 黄 色 大片| 婷婷成人五月综合激情| 国产成人无码区免费网站| 国模大尺度啪啪| 久久久噜噜噜久久熟女色| 久久精品水蜜桃av综合天堂| www国产精品内射老师| 国产无夜激无码av毛片| 激情综合色综合啪啪五月丁香搜索| 成人免费无码大片a毛片| 深夜福利啪啪片| 成人亚洲一区无码久久| 人妻av无码专区| 亚洲国产精品无码久久久久高潮| 久久亚洲中文字幕伊人久久大| 无码帝国www无码专区色综合 | 亚洲综合日韩av无码毛片| 精品国产一区二区三区av性色| 醉酒后少妇被疯狂内射视频| 国色天香成人一区二区| 国产无遮挡吃胸膜奶免费看| 国产精品爽爽久久久久久竹菊| 97久久超碰精品视觉盛宴| 最爽爱爱高潮免费视频|