在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RAB27B Antibody

  • 中文名稱:
    RAB27B兔多克隆抗體
  • 貨號:
    CSB-PA019178ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA019178ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RAB27B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    RAB27B
  • 別名:
    C25KG antibody; Rab27b antibody; RAB27B member RAS oncogene family antibody; RAS associated protein RAB27B antibody; Ras related protein Rab 27b antibody; Ras related protein Rab27b antibody; Ras-related protein Rab-27B antibody; RB27B_HUMAN antibody; Small GTP binding protein rab27b antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Ras-related protein Rab-27B protein (1-218AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1. May be involved in targeting uroplakins to urothelial apical membranes.
  • 基因功能參考文獻:
    1. Data indicate that a significant correlation between rab GTP-binding protein (RAB27B) and p53 tumor suppressor protein (p53) expression was observed. PMID: 26418905
    2. MiR-193a-3p and miR-193a-5p play important roles in osteosarcoma metastasis through down-regulation of the Rab27B and SRR genes and therefore may serve as useful biomarkers for the diagnosis of osteosarcoma PMID: 26913720
    3. These data indicate that Rab27B is involved at a different steps of zymogen granule maturation and secretion, which is distinct from that of Rab3D. PMID: 26845357
    4. Decreased invasion partly resulted from reduced expression and activation of MMP-9 after Rab27b knockdown. Downregulation of Rab27b also suppressed tumor growth in vivo. PMID: 26165699
    5. Data indicate that the secretion of microRNA miR-143, depends on rab GTP-binding proteins Rab7a and Rab27b. PMID: 26348397
    6. Rab27B nuclear expression is correlated with several clinicopathological features of GIST patients, and it may serve as an unfavorable prognostic marker. PMID: 25382899
    7. inhibiting V-ATPase activity by interfering agents and drugs might be an effective strategy for blocking Rab27B-dependent proinvasive secretory vesicle trafficking in ERalpha-positive breast cancer patients PMID: 23390068
    8. findings suggest that overexpression of Rab27B in BC coincides with lymph node metastasis and acquisition of a poor prognostic phenotype PMID: 23217148
    9. These results suggest that Rab27b negatively regulates the cell surface expression of c-kit via secretion of SCF and that ligation of SCF leads to the endolysosomal degradation system of c-kit. PMID: 22349512
    10. in human breast cancer specimens, the presence of Rab27B protein proved to be associated with a low degree of differentiation and the presence of lymph node metastasis in ER-positive breast cancer PMID: 21304180
    11. were unable to find any mutation in the coding sequence of RAB27B in five patients suffering from different types of platelet delta-storage pool deficiency PMID: 21198862
    12. Rab27b is associated with tubulovesicle membranes in the parietal cell and Rab27b may play a role in stimulation-associated membrane recruitment and gastric acid secretion. PMID: 20888820
    13. Rab27B regulates invasive growth and metastasis in ER-positive breast cancer cell lines, and increased expression is associated with poor prognosis in humans. PMID: 20484105
    14. Chromosomal mapping and gene structure of the RAB27B gene. PMID: 11178108
    15. During primate spermiogenesis, dynein, myosin Va, MyRIP and Rab27b that compose microtubule-based and actin-based vesicle transport systems are actually present in the manchette and might possibly be involved in intramanchette transport. PMID: 18478159

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Lipid-anchor. Late endosome.
  • 蛋白家族:
    Small GTPase superfamily, Rab family
  • 組織特異性:
    Expressed primarily in testis.
  • 數據庫鏈接:

    HGNC: 9767

    OMIM: 603869

    KEGG: hsa:5874

    STRING: 9606.ENSP00000262094

    UniGene: Hs.25318



主站蜘蛛池模板: 美女裸体跪姿扒开屁股无内裤 | 亚洲成a人片在线观看高清| 日本一二免费不卡区| 成人啪精品视频网站午夜| 亚欧av无码乱码在线观看性色| 欧美成人一区二免费视频软件| 51视频国产精品一区二区| 国产av大陆精品一区二区三区| 一边摸一边叫床一边爽av| 粗大的内捧猛烈进出| 牛和人交xxxx欧美| 女人裸露免费视频无遮挡网站| 日韩在线看片免费人成视频播放| 法国伦理少妇愉情| 国内精品久久久人妻中文字幕| 亚洲龙腾成小说人网| 久热在线播放中文字幕| 99re8这里有精品热视频免费| 欧美又粗又长又爽做受| 成人做爰高潮片免费视频| 九九久久精品国产| 熟女体下毛毛黑森林| 中文字幕人妻a片免费看| 国产精品55夜色66夜色| 欧美又粗又大xxxxbbbb疯狂| 亚洲国产天堂久久综合| 少妇spa推油被扣高潮| 亚洲午夜无码久久久久软件| 国语精品一区二区三区| 四虎永久免费地址入口| 国产亚洲人成网站在线观看| 人人妻人人玩人人澡人人爽| 成人免费无遮挡无码黄漫视频| 人妻少妇无码精品专区| 国产人成视频在线观看| 中文字幕在线观看亚洲日韩| 国产精品无码久久av不卡| 亚洲欧美成人精品香蕉网| 国产精品v欧美精品∨日韩| 亚洲国产精品13p| 天堂av成年av影视|