在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RAB23 Antibody

RAB23 Antibody

  • 中文名稱：
    RAB23兔多克隆抗體
  • 貨號：
    CSB-PA891960ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: RAB23 antibody at 3.88μg/ml
      Lane 1: Mouse ocular tissue
      Lane 2: Rat brain tissue
      Lane 3: Mouse kidney tissue
      Lane 4: Mouse lung tissue
      Lane 5: Mouse brain tissue
      Lane 6: NIH/3T3 whole cell lysate
      Lane 7: MCF-7 whole cell lysate
      Lane 8: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 27 kDa
      Observed band size: 27 kDa
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA891960ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA891960ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品描述：

    CUSABIO's product CSB-PA891960ESR1HU is a polyclonal antibody raised in the rabbit against a peptide mapping within amino acids 1-237 of the human RAB23 protein. This RAB23 antibody occurs as an unconjugated IgG. Purification by antigen affinity method reaches a relatively high purity. It is reactive to human, mouse, and rat samples. And it has been demonstrated to recognize RAB23 protein in the ELISA, WB, and IHC applications. Its target protein RAB23 is a small GTPase that exerts important development functions in vertebrates and regulates Sonic hedgehog (Shh) and Nodal signaling.

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RAB23 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RAB23
  • 別名：
    DKFZp781H0695 antibody; HSPC137 antibody; MGC8900 antibody; Rab 23 antibody; RAB family small GTP binding protein RAB 23 antibody; Rab23 antibody; RAB23; member RAS oncogene family antibody; RAB23_HUMAN antibody; Ras related protein Rab 23 antibody; Ras-related protein Rab-23 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Ras-related protein Rab-23 protein (1-237AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.
  • 基因功能參考文獻：
    1. Genetic variants in RAB23 and ANXA11 genes were associated with an increased risk of sarcoidosis-associated uveitis. PMID: 29416296
    2. miR-429 was down-regulated in hepatocellular carcinoma (HCC) tissues and cells. Up regulation of miR-429 decreased the migratory capacity and reversed the EMT to MET in HCC cells. RAB23 was confirmed as a target of miR-429. PMID: 29191386
    3. Down-regulation of Rab23 suppressed the proliferation, migration and invasion of prostate cancer cells. PMID: 28277196
    4. Rab23 serves as an important oncoprotein in human astrocytoma by regulating cell invasion and migration through Rac1 activity PMID: 26897750
    5. High Rab23 expression is associated with bladder cancer. PMID: 26715272
    6. Forced expression of MiR-92b decreased the mRNA and protein level of RAB23, and RAB23 rescued the biological functions of miR-92b. Taken together, this study revealed the oncogenic roles and the regulation of RAB23 in esophageal squamous cell carcinoma, suggesting RAB23 might be a therapeutic target PMID: 27659550
    7. Rab23 enhance squamous cell carcinoma cell invasion via up-regulating Rac1. PMID: 26648292
    8. Rab23 is expressed in breast cancer cells, and ectopic expression of Rab23 inhibits the growth and proliferation as well as induces cell apoptosis in breast cancer cells These effects may be due to the inhibition by Rab23 of Gli1 and Gli2 mRNA expression PMID: 26238143
    9. Data indicate the essential role of GTP binding protein RAB 23 (Rab23) in pancreatic ductal adenocarcinoma (PDAC) inva-sion, motility and metastasis. PMID: 25867419
    10. Rab23 was a target gene of miR-367, and ectopic expression of Rab23 could reverse the invasion and migration inhibitory activity of miR-367. PMID: 25489984
    11. The inhibition of the Rab23 cycle decreases the expression and nuclear localization of Gli1. PMID: 23007279
    12. Rab23 expression level was the highest in Bcap-37 cells. PMID: 23948406
    13. Rab9A and Rab23 GTPases play crucial roles in autophagy of Group A Streptococcus. PMID: 22452336
    14. association of the 6p12.1 locus with sarcoidosis implicates this locus as a further susceptibility factor and RAB23 as a potential signalling component PMID: 21540310
    15. Carpenter syndrome: extended RAB23 mutation spectrum and analysis of nonsense-mediated mRNA decay PMID: 21412941
    16. A RAB23 mutation (c.86dupA) present in the homozygote state in four relatives of Comorian origin with Carpenter syndrome, is reported. PMID: 20358613
    17. Rab23 is overexpressed and/or activated in hepatocellular carcinoma (HCC). Rab23 may be both a HCC predictor and a target for treating HCC. PMID: 17373734
    18. RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development. PMID: 17503333
    19. Data show that RAB23 participates in central nervous system development. PMID: 18485483
    20. RAB23 amplifications are associated with gastric cancer PMID: 18559507

    顯示更多

    收起更多

  • 相關疾病：
    Carpenter syndrome 1 (CRPT1)
  • 亞細胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Cytoplasmic vesicle, autophagosome. Endosome membrane. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 數據庫鏈接：

    HGNC: 14263

    OMIM: 201000

    KEGG: hsa:51715

    STRING: 9606.ENSP00000320413

    UniGene: Hs.555016



主站蜘蛛池模板： 久久精品亚洲日本波多野结衣 | 高清破外女出血av毛片| 日本一道一区二区视频| 成人网站www污污污网站| 欧洲熟妇色xxxx欧美老妇多毛| 人妻人人做人做人人爱| 99尹人香蕉国产免费天天| 又色又爽又黄的美女裸体网站| 免费人成视频19674不收费 | 色伦专区97中文字幕| 日本丰满熟妇hd| 国产精品99久久久精品无码| 西西人体扒开下部试看120秒| 天堂中文资源库官网| 无码精品a∨在线观看十八禁| 国产视频一区二区| 国产免费视频| 国产又黄又爽又色的免费| 亚洲中文字幕国产综合| 精品无码人妻一区二区三区| 日本japanese丰满白浆| 亚洲人成网站在线无码| 中国美女牲交视频| 桃花色综合影院| 99久久99久久久精品齐齐综合色圆| 国产成人精品久久一区二区| 亚洲欧美日韩综合久久久久久| www污污污抽搐喷潮com| 新版资源天堂中文| 亚洲不卡1卡2卡三卡入口| 538在线精品视频| 国模大尺度啪啪| 亚洲一区在线日韩在线尤物| 国产精品无码无卡在线播放| 亚洲精品久久久久久下一站| 国产午夜精华无码网站| 日本xxxx裸体xxxx视频大全| 少妇av一区二区三区无码| 99精品国产福利在线观看| а天堂中文最新版在线| 欧美内射rape视频|