在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RAB22A Antibody

  • 中文名稱:
    RAB22A兔多克隆抗體
  • 貨號:
    CSB-PA265650
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA265650(RAB22A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: MCF7 cells, Primary antibody: CSB-PA265650(RAB22A Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    3732413A17Rik antibody; AI662177 antibody; AW319644 antibody; AW550514 antibody; E130120E14Rik antibody; GTP binding protein RAB22A antibody; MGC16770 antibody; OTTMUSP00000017605 antibody; Rab 22 antibody; RAB 22A antibody; Rab-22 antibody; Rab22 antibody; RAB22A antibody; RAB22A member RAS oncogene family antibody; Ras related protein Rab 22A antibody; Ras related protein Rab22A antibody; Ras-related protein Rab-22A antibody; RB22A_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human RAB22A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.
  • 基因功能參考文獻:
    1. RAB22A is significantly upregulated in melanoma, plays an oncogenic role in the malignant phenotypes of melanoma cells, and its expression in melanoma is regulated by epigenetical mechanism. PMID: 27690221
    2. that Rab22a enhances recycling of CD147, which is required for lung cancer cell migration and invasion PMID: 28433697
    3. Rab3A-22A blocks exocytosis at a stage downstream intra-acrosomal calcium release. PMID: 27613869
    4. RAB22A role in epithelial-mesenchymal transition of melanoma cells PMID: 27237979
    5. the HOTAIR lncRNA positively regulated the protein expression of Rab22a through competition for miR-373 binding. the positive regulation between HOTAIR and Rab22a may be partially attributed to the ceRNA regulatory network via miR-373, indicating a potential therapeutic target for ovarian cancer. PMID: 27484896
    6. miR-204 suppressed renal cell carcinoma proliferation and invasion by directly targeting the RAB22A gene. PMID: 26883716
    7. Data show that Rab22a- and Rab5a-driven phagosomal uptake is a crucial step in the vesicular cascade that leads to elimination of spirochetes by macrophages. PMID: 26344766
    8. our results demonstrated that miR-203 act as a tumor suppressor miRNA through regulating RAB22A expression and suggested its involvement in osteosarcoma progression and carcinogenesis. PMID: 26382657
    9. Vaccinia virus traffics to early endosomes, where recycling endosome markers Rab11 and Rab22 are recruited to participate in subsequent virus trafficking prior to virus core uncoating in the cytoplasm. PMID: 26041286
    10. these results demonstrate that miR-373 suppresses epithelial ovarian cancer invasion and metastasis by directly targeting Rab22a gene PMID: 25460499
    11. Re-expression of miR-193b in breast cancer cell lines decreased DNAJC13 (HPS40) and RAB22A expression, providing a mechanism by which mir193-b acts as a tumor suppressor. PMID: 25550792
    12. miR-204-5p acts as a tumor suppressor in colorectal cancer through inhibiting RAB22A and reveal RAB22A to be a new oncogene and prognostic factor for colorectal cancer. PMID: 25294901
    13. Exposure of human breast cancer cells to hypoxia augments microvesicle (MVs) shedding that is mediated by the HIF-dependent expression of the small GTPase RAB22A, which colocalizes with budding MVs at the cell surface. PMID: 24938788
    14. Data report the identification of Rab22 as a binding site on early endosomes for direct recruitment of Rabex-5 and activation of Rab5, establishing a Rab22-Rab5 signaling relay to promote early endosome fusion. PMID: 19759177
    15. Rab22a may regulate the dynamic interactions of endosomal compartments and it may be involved in the communication between the biosynthetic and early endocytic pathways. PMID: 11870209
    16. Rab22a regulates different steps in the recycling of cargo protein that has entered the cell independently of clathrin. PMID: 15181155
    17. Rab22a can affect the trafficking from endosomes to the Golgi apparatus probably by promoting fusion among endosomes and impairing the proper segregation of membrane domains required for targeting to the trans-Golgi network (TGN). PMID: 15748882
    18. Rab22a controls the transport of the transferrin receptor from sorting to recycling endosomes. PMID: 16537905

    顯示更多

    收起更多

  • 亞細胞定位:
    Endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Early endosome. Late endosome. Cell projection, ruffle. Cytoplasmic vesicle. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族:
    Small GTPase superfamily, Rab family
  • 數據庫鏈接:

    HGNC: 9764

    OMIM: 612966

    KEGG: hsa:57403

    STRING: 9606.ENSP00000244040

    UniGene: Hs.529044



主站蜘蛛池模板: 久久精品无码一区二区无码| 日日鲁鲁鲁夜夜爽爽狠狠视频97| 动漫av网站免费观看| 国内揄拍国产精品人妻门事件| 无码国内精品久久人妻蜜桃| 婷婷五月深爱综合开心网| 亚洲成a人片在线观看的电影| 熟妇人妻无码中文字幕| 激情综合色综合啪啪开心| 国产成人av免费网址| 成人网站免费高清视频在线观看| 成人女人看片免费视频放人| 久久精品国产99久久久古代| 亚洲 自拍 另类 欧美 综合| 亚洲综合欧美在线一区在线播放 | 九色综合九色综合色鬼| 一区二区三区在线 | 日本| 久久精品国产99国产精品| 亚洲已满18点击进入在线看片| 成年午夜精品久久久精品| 99爱在线精品视频免费观看| 丰满少妇大力进入| 五月开心播播网| 人人妻人人澡人人爽国产| 日本亚州视频在线八a| 亚洲视频一区| 18精品久久久无码午夜福利| 亚洲另类欧美综合在线| 亚洲自偷自偷偷色无码中文| 蜜臀av夜夜澡人人爽人人| 日本人妻人人人澡人人爽| 国精品人妻无码一区二区三区蜜柚| 成人18禁深夜福利网站app免费| 欧美日韩色另类综合| 色喜国模李晴超大尺度| 人妻熟女一区二区aⅴ水野朝阳| 97久久精品人人做人人爽| 国产爆乳无码视频在线观看3| 免费国产成人高清在线视频| 国产精品乱码高清在线观看| 99国产精品自在自在久久|