在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RAB1B Antibody

  • 中文名稱:
    RAB1B兔多克隆抗體
  • 貨號:
    CSB-PA060223
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    RAB1B
  • 別名:
    RAB1B antibody; RAB1B member RAS oncogene family antibody; RAB1B_HUMAN antibody; Ras related protein Rab1B antibody; Ras-related protein Rab-1B antibody; Small GTP binding protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human Rab 1B.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment.
  • 基因功能參考文獻:
    1. Rab1b differentially controls the secretion of apolipoproteins and of HCV. PMID: 29020629
    2. Survival analysis indicates that patients with overexpression of Rab1B or MMP9 have significantly worse overall survival and progression-free survival, but better response to chemotherapy than those with low expression of proteins, and that Rab1B is an independent prognostic factor for colorectal cancer patients. PMID: 28316326
    3. Authors demonstrate that Rap1b expression is aberrantly increased in GC, resulting in the inhibition of autophagy and apoptosis of GC cells by the PI3K/Akt/mTOR pathway. PMID: 27712585
    4. RAB1B localization to the Golgi. PMID: 26977884
    5. RAB1B acts as a metastasis suppressor in triple-negative breast cancer by regulating the TGF-beta/SMAD signaling pathway and RAB1B may serve as a biomarker of prognosis and response to anti-tumor therapeutics for patients with triple-negative breast cancer. PMID: 25970785
    6. Our results show, for the first time, that changes in Rab1b levels modulate gene transcription and strongly suggest that a Rab1b increase is required to elicit a secretory response. PMID: 23325787
    7. The crystal structure of the Rab1b-LepB complex. PMID: 23288104
    8. results indicate that the cellular localization of MTMR6 is regulated by Rab1B in the early secretory and autophagic pathways PMID: 23188820
    9. The detailed molecular reaction mechanism of a complex between human Rab and RabGAP at the highest possible spatiotemporal resolution and in atomic detail, is described. PMID: 23236136
    10. Rab1a/b and Rab43, are important for herpes simplex virus 1 virion assembly PMID: 21680502
    11. Rab1b is a key regulatory component of COPII dynamics and function. PMID: 21093099
    12. Antibacterial autophagy occurs at omegasomes and reveal that the Rab1 GTPase plays a crucial role in mammalian autophagy. PMID: 20980813
    13. The authors demonstrate that Rab1b-activated GBF1 and ARF1 are involved in Ebolavirus virion formation, suggesting that both the COPII and COPI transport systems play a role in Ebolavirus VP40-mediated particle formation. PMID: 20164217
    14. These data support a model where Rab1b-GTP induces GBF1 recruitment at the ERES interface and at the Golgi complex where it is required for COPII/COPI exchange or COPI vesicle formation, respectively. PMID: 17429068
    15. findings show that SidM from Legionella pneumophila could act as both a GDP-GTP exchange factor and GDP-dissociation inhibitor-displacement factor (GDF) for Rab1 PMID: 17947549

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Membrane; Lipid-anchor; Cytoplasmic side. Preautophagosomal structure membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, perinuclear region.
  • 蛋白家族:
    Small GTPase superfamily, Rab family
  • 數據庫鏈接:

    HGNC: 18370

    OMIM: 612565

    KEGG: hsa:81876

    STRING: 9606.ENSP00000310226

    UniGene: Hs.300816



主站蜘蛛池模板: 97影院理论午夜伦不卡| 99久久久无码国产精品9| 天天摸日日摸狠狠添| 久久久久国产一区二区| 亚洲国产美国国产综合一区| 亚洲熟妇av综合网五月| 丰满熟妇乱又伦| 护士脱了内裤让我爽了一夜视频| 亚洲 欧美 天堂 综合| 无码伊人66久久大杳蕉网站谷歌| 宅男噜噜噜66网站在线观看| 色欲欲www成人网站| 亚洲国产成人久久综合同性| 久久精品超碰av无码| 一 级 黄 色 片免费网站| 少妇特殊按摩高潮惨叫无码| 亚洲孰妇无码av在线播放 | 无码人妻丰满熟妇a片护士| 亚洲精品色在线网站| 亚洲国产成人精品无码区软件| 久久婷婷五月综合色俺也想去| 国产精品美女久久久久av爽| 国产麻豆剧传媒精品av| 国产成人精品免费视频大全五级 | 久久久国产一区二区三区| 国产女爽爽精品视频天美传媒| 久久综合九色综合97网| 99热成人精品国产免费| 欧美饥渴熟妇高潮喷水水| 日韩精品一区二区三区中文| 国产白丝精品爽爽久久久久久蜜臀 | 成在人线av无码免观看| 99久久超碰中文字幕伊人| 两个人看的www免费视频中文| 未满小14洗澡无码视频网站| 中文字幕亚洲乱码熟女一区二区| 午夜男女无遮掩免费视频| 大陆极品少妇内射aaaaa| 无码一区二区波多野结衣播放搜索| 亚洲欧美一区二区成人片| 国产公妇仑乱在线观看|