在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RAB10 Antibody, FITC conjugated

RAB10 Antibody, FITC conjugated

  • 中文名稱：
    RAB10兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA019152LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RAB10 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    GTP binding protein RAB10 antibody; Rab10 antibody; RAB10 member RAS oncogene family antibody; RAB10_HUMAN antibody; Ras related GTP binding protein antibody; Ras related GTP binding protein RAB10 antibody; Ras-related protein Rab-10 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ras-related protein Rab-10 protein (1-196AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane. In epithelial cells, it regulates transport from the Golgi to the basolateral membrane. May play a role in the basolateral recycling pathway and in phagosome maturation. May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion. Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis. When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis.; (Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication. Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole.
  • 基因功能參考文獻：
    1. miR378a3p may act as a tumorsuppressor in Esophageal squamous cell carcinoma cells through negatively regulating Rab10. PMID: 29693138
    2. Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils has been reported. PMID: 29127255
    3. Our results suggest that RAB10 could be a promising therapeutic target for Alzheimer's Disease prevention PMID: 29183403
    4. RAB10 regulates cell survival and proliferation through multiple oncogenic, cell stress and apoptosis pathways. More importantly, high RAB10 expression levels in HCC cells correlated with a poor prognosis in HCC patients. PMID: 28460436
    5. miR-329 also suppresses wound-healing and migration ability of osteosarcoma cells and inhibits tumorigenicity in vivo. Rab10 was identified as a target of miR-329 in osteosarcoma and mediates its biofunction PMID: 27487475
    6. Data suggest that MGCRABGAP is involved in mammalian spermiogenesis by modulating RAB10. PMID: 28067790
    7. the target gene RAB10 regulated by miRNA-369-3p, miRNA-30e-5p, miRNA-30e-3p, and miRNA-655 may play key role in the progression and development of AD. PMID: 26082458
    8. The Anaplasma phagocytophilum surface protein, uridine monophosphate kinase, was identified as a guanine nucleotide-independent, Rab10-specific ligand. PMID: 26289115
    9. Rab10 is a target of the GTPase-activating protein AS160, which is inhibited after phosphorylation by the protein kinase Akt. PMID: 25103239
    10. Rab10 silencing increased the plasma membrane residence of HAS3, resulting in a significant increase of hyaluronan secretion and an enlarged cell surface HA coat, whereas Rab10 overexpression suppressed hyaluronan synthesis. PMID: 24509846
    11. Rab10 regulates endoplasmic reticulum dynamics/morphology. Suggest that these dynamics could be coupled to phospholipid synthesis. PMID: 23263280
    12. Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C PMID: 21454697
    13. Rab10 and Rab8A are new cytoplasmic factors implicated in WPB biogenesis that play a role in generating granules that can rapidly respond to secretagogue PMID: 21070595
    14. Rab10, acting upstream of Rab5, plays a prominent role in phagolysosome formation and can modulate Mycobacterium-containing phagosomes maturation PMID: 20028485
    15. Fibronectin 1 and RAB10 show elevated expression in uninvolved psoriatic epidermis. PMID: 15855153
    16. a related Rab protein, Rab10, can interact with myosin Va, myosin Vb, and myosin Vc PMID: 19008234

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Recycling endosome membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasm, cytoskeleton, cilium basal body. Endoplasmic reticulum membrane. Cytoplasm, perinuclear region.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 組織特異性：
    Expressed in the hippocampus. Expressed in neutrophils (at protein level).
  • 數據庫鏈接：

    HGNC: 9759

    OMIM: 612672

    KEGG: hsa:10890

    STRING: 9606.ENSP00000264710

    UniGene: Hs.467960



主站蜘蛛池模板： 日本乱理伦片在线观看中文| 国产欧美日韩亚洲18禁在线| 国产主播一区二区三区在线观看| 国产卡一卡二卡三卡免费| 野外少妇激情aa 级视频| 久久国产加勒比精品无码| 国产农村妇女毛片精品久久| 国产精自产拍久久久久久蜜| 国产精品一卡二卡三卡| 国产av久久人人澡人人爱| 免费网禁国产you女网站下载| 美国人性欧美xxxx| 久久人妻av中文字幕| 久久久久人妻一区精品色欧美| 亚洲欧美日韩综合在线一| 精品国内综合一区二区| 亚洲国产欧美在线观看片不卡 | 亚洲精品久久久久中文字幕| 日韩精品久久无码人妻中文字幕| 亚洲欧美色一区二区三区| 无码av天天av天天爽| 日本高清色www网站色噜噜噜| 亚洲色中文字幕在线播放| 浪潮av激情高潮国产精品| 欧洲亚洲色一区二区色99| 3p人妻少妇对白精彩视频| 国产精品毛片在线完整版| 久久精品免费一区二区三区| 亚洲精品一线二线三线无人区| 国产一区二区三区四区五区加勒比 | 久久人人97超碰a片精品| 国产男小鲜肉同志免费| 成人区人妻精品一熟女| 日韩日韩日韩日韩日韩| 亚洲伊人久久综合成人| 国产乱子伦一区二区三区视频播放| 中文字幕无码无码专区| 久久精品天天中文字幕人妻| 日韩精品一卡2卡三卡4卡| 超清精品丝袜国产自在线拍| 精品无码一区二区三区av|