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  4. QTRT1 Antibody, Biotin conjugated

QTRT1 Antibody, Biotin conjugated

  • 中文名稱：
    QTRT1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA887150LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) QTRT1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    QTRT1
  • 別名：
    FP3235 antibody; Guanine insertion enzyme antibody; qtrt1 antibody; Queuine tRNA ribosyltransferase 1 antibody; Queuine tRNA ribosyltransferase antibody; Queuine tRNA-ribosyltransferase antibody; TGT antibody; TGT, 43 KD subunit antibody; TGT, catalytic subunit antibody; TGT_HUMAN antibody; TGUT antibody; tRNA guanine transglycosylase antibody; tRNA-guanine transglycosylase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Queuine tRNA-ribosyltransferase catalytic subunit 1 protein (211-403AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
  • 基因功能參考文獻：
    1. Homology models of C elegans Tgt and human Tgt suggest that the replacement of Cys158 and Val233 in bacterial Tgt (Zymomonas mobilis) by valine and accordingly glycine in eucaryotic Tgt largely accounts for the different substrate specificities. PMID: 23704982
    2. the inhibition of the human TGT by biopterin, consistent with earlier reports on other eukaryal TGTs, and supportive of the concept that pteridines may regulate eukaryal TGT activity in vivo. PMID: 21640076
    3. phylogenetic and kinetic analyses support the conclusion that all tRNA-guanine transglycosylases have divergently evolved to specifically recognize their cognate heterocyclic substrates. PMID: 21131277
  • 亞細胞定位：
    Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Queuine tRNA-ribosyltransferase family
  • 數據庫鏈接：

    HGNC: 23797

    OMIM: 609615

    KEGG: hsa:81890

    STRING: 9606.ENSP00000250237

    UniGene: Hs.631638



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