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  4. QPRT Antibody, Biotin conjugated

QPRT Antibody, Biotin conjugated

  • 中文名稱：
    QPRT兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA621868LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) QPRT Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    QPRT
  • 別名：
    NADC_HUMAN antibody; Nicotinate nucleotide pyrophosphorylase (carboxylating) antibody; Nicotinate-nucleotide pyrophosphorylase [carboxylating] antibody; QAPRTase antibody; QPRT antibody; QPRTase antibody; Quinolinate phosphoribosyltransferase [decarboxylating] antibody; Quinolinate phosphoribosyltransferase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Nicotinate-nucleotide pyrophosphorylase [carboxylating] protein (113-254AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in the catabolism of quinolinic acid (QA).
  • 基因功能參考文獻：
    1. Our data suggest that QPRT may play an important role in the pathogenesis of autism spectrum disorders in Chr16p11.2 deletion carriers. PMID: 30443311
    2. WT1 knock-down gave a corresponding decrease in QPRT gene and protein expression. Chromatin-immunoprecipitation revealed WT1 binding to a conserved site in the first intron of the QPRT gene. PMID: 27889611
    3. The structural features, size distribution, heat aggregation and ITC studies of the full-length enzyme and the enzyme lacking helix alpha1 strongly suggest that human QPRT acts as a hexamer for cooperative reactant binding via three dimeric subunits and maintaining stability. PMID: 26805589
    4. Report of the crystal structure of human QPRT bound to its inhibitor phthalic acid (PHT) and kinetic analysis of PHT inhibition of human QPRT. PMID: 24038671
    5. QPRT is a potential new marker for the immunohistochemical screening of follicular thyroid nodules. PMID: 19321014

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  • 蛋白家族：
    NadC/ModD family
  • 數據庫鏈接：

    HGNC: 9755

    OMIM: 606248

    KEGG: hsa:23475

    STRING: 9606.ENSP00000378782

    UniGene: Hs.513484



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