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QARS Antibody

  • 中文名稱:
    QARS兔多克隆抗體
  • 貨號:
    CSB-PA019132DSR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: Glutamine--tRNA ligase antibody at 2μg/ml
      Lane 1: PC-3 whole cell lysate
      Lane 2: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 88, 87 kDa
      Observed band size: 88 kDa
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA019132DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA019132DSR1HU at dilution of 1:100
    • Immunoprecipitating QARS in Hela whole cell lysate
      Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA019132DSR1HU in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
      Lane 2: CSB-PA019132DSR1HU (4μg) + Hela whole cell lysate (500μg)
      Lane 3: Hela whole cell lysate (20μg)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) QARS Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    QARS
  • 別名:
    GlnRS antibody; Glutamine tRNA ligase antibody; Glutamine tRNA synthetase antibody; Glutamine--tRNA ligase antibody; Glutaminyl tRNA ligase antibody; Glutaminyl tRNA synthetase antibody; Glutaminyl-tRNA synthetase antibody; PRO2195 antibody; QARS antibody; SYQ_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Glutamine--tRNA ligase protein (1-250AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC, IP
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Glutamine--tRNA ligase. Plays a critical role in brain development.
  • 基因功能參考文獻:
    1. patient's fibroblasts demonstrated markedly reduced QARS amino acylation activity in vitro PMID: 28620870
    2. hcmv-miR-US4-1 may involve in promoting cell apoptosis and benefiting discharge of infectious virus particles via down-regulation of QARS in HCMV-infected HELF cells. PMID: 27240979
    3. Pathological mutations mapping in the N-terminal domain alter the domain structure, and decrease catalytic activity and stability of GlnRS, whereas missense mutations in the catalytic domain induce misfolding of the enzyme. PMID: 26869582
    4. Data indicate compound heterozygous mutations [c.169T>C (p.Tyr57His) and c.1485dup (p.Lys496*)] in QARS, which encodes glutaminyl-tRNA synthetase, in two siblings with early-onset epileptic encephalopathy (EOEE). PMID: 25471517
    5. interactions between the N-terminal domains of ArgRS and AIMP1 are important for the catalytic and noncatalytic activities of ArgRS and for the assembly of the higher-order MSC protein complex with ArgRS-GlnRS-AIMP1 PMID: 25288775
    6. results highlight the importance of QARS during brain development and that epilepsy due to impairment of QARS activity is unusually severe in comparison to other aminoacyl-tRNA synthetase disorders PMID: 24656866
    7. Data indicate that glutaminyl-tRNA synthetase splice variant GlnRSDeltaiABD was present in exosomes extruded from Jurkat cells and functional in protein synthesis. PMID: 24003230

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  • 相關疾病:
    Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy (MSCCA)
  • 亞細胞定位:
    Cytoplasm, cytosol. Cytoplasm.
  • 蛋白家族:
    Class-I aminoacyl-tRNA synthetase family
  • 組織特異性:
    Highly expressed in fetal cerebral cortex, particularly in the ventricular zone, inner subventricular zone, outer subventricular zone, and cortical plate.
  • 數據庫鏈接:

    HGNC: 9751

    OMIM: 603727

    KEGG: hsa:5859

    STRING: 9606.ENSP00000307567

    UniGene: Hs.79322



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