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  4. Phospho-SGK223 (Y413) Antibody

Phospho-SGK223 (Y413) Antibody

  • 中文名稱：
    磷酸化-SGK223 (Y413)兔多克隆抗體
  • 貨號：
    CSB-PA007578
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of A549 cells using Phospho-Pragmin (Y413) Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    PRAG1
  • 別名：
    D8Ertd82e antibody; DKFZp761P0423 antibody; DNA segment, Chr 8, ERATO Doi 82 antibody; EC 2.7.10.2 antibody; Homolog of rat pragma of Rnd2 antibody; LOC157285 antibody; PRAGMIN antibody; SG223_HUMAN antibody; Sgk223 antibody; Sugen kinase 223 antibody; Tyrosine protein kinase SgK223 antibody; Tyrosine-protein kinase SgK223 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human Pragmin around the phosphorylation site of Y413.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth. Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism. Acts as a critical coactivator of Notch signaling.
  • 基因功能參考文獻：
    1. analysis of how the kinase fold mediates non-catalytic functions in SgK223 PMID: 29079850
    2. deregulation of the Pragmin-Csk axis may induce aberrant cell migration that contributes to tumor invasion and metastasis PMID: 27116701
    3. Results provide evidence that NACK was strongly expressed in a subset of non-small cell lung cancer (NSCLCL) samples and interference of NACK inhibits NSCLC progression through failing to activate Notch1 signaling complexes. PMID: 26782286
    4. Increased expression of SgK223 occurs in PDAC, and overexpression of SgK223 in pancreatic ductal epithelial cells promotes acquisition of a migratory and invasive phenotype through enhanced JAK1/Stat3 signaling PMID: 26215634
    5. Pragmin as a mammalian EPIYA effector and suggests that bacterial EPIYA effectors target Pragmin to subvert SFKs for successful infection. PMID: 21873224
    6. Rnd2 regulates neurite outgrowth by functioning as the RhoA activator through Pragmin, in contrast to Rnd1 and Rnd3 inhibiting RhoA signaling PMID: 16481321
    7. Also known as SgK223, a member of the NKF3 subfamily of eukaryotic protein kinases. PMID: 12471243

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  • 亞細胞定位：
    Cytoplasm. Cell junction, focal adhesion. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily
  • 數據庫鏈接：

    HGNC: 25438

    OMIM: 617344

    KEGG: hsa:157285

    STRING: 9606.ENSP00000330930

    UniGene: Hs.583863



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