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Phospho-SF1 (S82) Antibody

  • 中文名稱:
    磷酸化-SF1 (S82)兔多克隆抗體
  • 貨號:
    CSB-PA060104
  • 規格:
    ¥1090
  • 圖片:
    • Western blot analysis of SH-SY5Y 293T using p-Splicing factor 1 (S82) antibody.
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SF1
  • 別名:
    SF1 antibody; ZFM1 antibody; ZNF162 antibody; Splicing factor 1 antibody; Mammalian branch point-binding protein antibody; BBP antibody; mBBP antibody; Transcription factor ZFM1 antibody; Zinc finger gene in MEN1 locus antibody; Zinc finger protein 162 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Monkey
  • 免疫原:
    Synthesized peptide derived from Human Splicing factor 1 around the phosphorylation site of S82.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.
  • 基因功能參考文獻:
    1. SF1 Phosphorylation Enhances Specific Binding to U2AF(65) and Reduces Binding to 3'-Splice-Site RNA PMID: 28002734
    2. A novel function of SF1 in the initial recruitment of the U2 snRNP through direct interactions with two U2 snRNP-associated proteins. PMID: 26420826
    3. Data suggest that post-translational processing of SF1 (phosphorylation of Ser20) down-regulates nuclear import of SF1 via alterations in kinetic interaction of SF1 nuclear localization signal (NLS) with NLS receptor isoforms. PMID: 25043850
    4. We demonstrated that PRPF40B interacts directly with SF1 and associates with U2AF(65 PMID: 25605964
    5. Gomafu indirectly modulates the function of the splicing factors SF1 and Celf3 by sequestering these proteins into separate nuclear bodies. PMID: 25145264
    6. The conserved SPSP motif phosphorylation and the SF1/U2AF interface are essential in vivo. PMID: 23273425
    7. Findings suggest that Zinc finger motif-1 (ZFM1) is an important factor for the stabilization of a contractile SMC phenotype under basal or mildly activating conditions. PMID: 22906951
    8. central ;mystery' domain of SF1 crystals belonged to space group C2 and have most probable solvent contents of 64, 52 or 39% with three, four or five molecules per asymmetric unit, respectively PMID: 21505248
    9. SF1 silencing affected alternative splicing of endogenous transcripts, establishing a previously unexpected role for SF1 and branch site-like sequences in splice site selection. PMID: 21062807
    10. the conformational changes that are induced by assembly of the SF1/U2AF(65)/RNA complex serve to position the pre-mRNA splice site optimally for subsequent stages of splicing. PMID: 21146534
    11. SF3a60, 66, and 120, but not SF1, are essential for pre-mRNA splicing PMID: 15647371
    12. SF1 was essential for the induction of alternative mRNA splicing by the beta-catenin/TCF4 complex. PMID: 17383426
    13. Puf60-UHM binds to ULM sequences in the splicing factors SF1, U2AF65, and SF3b155. PMID: 18974054
    14. The KH-QUA2 region of SF1 defines an enlarged KH (hn RNP K) fold which is necessary and sufficient for intron branched point sequence (BPS) binding. PMID: 11691992

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  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    BBP/SF1 family
  • 組織特異性:
    Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart.
  • 數據庫鏈接:

    HGNC: 12950

    OMIM: 601516

    KEGG: hsa:7536

    STRING: 9606.ENSP00000366604

    UniGene: Hs.502829



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