Phospho-NFKBIB (T19) Antibody
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中文名稱：磷酸化-NFKBIB (T19)兔多克隆抗體
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貨號：CSB-PA020117
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規格：￥1090
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圖片：
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Western Blot analysis of 293 cells using Phospho-IκB-β (T19) Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：I kappa B beta antibody; I-kappa-B-beta antibody; IkappaBbeta antibody; IKB beta antibody; IkB-B antibody; IkB-beta antibody; IKBB antibody; IKBB_HUMAN antibody; IkBbeta antibody; NF kappa BIB antibody; NF-kappa-B inhibitor beta antibody; NF-kappa-BIB antibody; Nfkbib antibody; Thyroid receptor interacting protein 9 antibody; Thyroid receptor-interacting protein 9 antibody; TR interacting protein 9 antibody; TR-interacting protein 9 antibody; TRIP-9 antibody; TRIP9 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from Human IκB-β around the phosphorylation site of T19.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:5000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
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基因功能參考文獻：
- The subcellular distributions of IkappaB and NFkappaB are indicative of carcinogenesis. Inhibition of XPO1 results in intranuclear retention of IkappaB, which inhibits NFkappaB and thereby provides a novel mechanism for drug therapy in sarcoma. This effect can be further enhanced in relatively selinexor-resistant sarcoma cell lines by pretreatment with the proteasome inhibitor carfilzomib. PMID: 28314790
- data suggest that miRNA-4776 modulates Influenza A virus production in infected cells through NFKBIB expression, possibly through the modulation of NF-kappaB. PMID: 28448456
- our data establish the importance of a novel tumor suppressive IKBB gene in abrogating angiogenesis in NPC via the NF-kappaB signalling pathway. PMID: 26227166
- NFKBIBrs3136641TT single nucleotide polymorphism was associated with a significantly decreased risk of developing wheezing. PMID: 25326706
- IkappaBbeta may be a novel target for transcription factors of the HMG-box SRY/Sox family and imply a potential role for NF-kappaB/IkappaBbeta in spermatogenesis PMID: 12475944
- VEGF increased Mn-superoxide dismutase promoter activity, an effect that was dependent on a second intronic NF-kappaB consensus motif. PMID: 15308628
- data indicate that inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta PMID: 15919917
- None of the NFKBIB SNPs are associated with pneumococcal susceptibility. PMID: 17463416
- increased I-kappaBbeta expression reversed NF-kappaB activation in cancer cells, compensating for the loss of I-kappaBalpha via TGase 2 polymerization. PMID: 18950638
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亞細胞定位：Cytoplasm. Nucleus.
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蛋白家族：NF-kappa-B inhibitor family
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組織特異性：Expressed in all tissues examined.
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數據庫鏈接：
