在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-MAP2K3 (T222) Antibody

  • 中文名稱:
    磷酸化-MAP2K3 (T222)兔多克隆抗體
  • 貨號:
    CSB-PA030303
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    AW212142 antibody; dual specificity mitogen activated protein kinase kinase 3 antibody; Dual specificity mitogen-activated protein kinase kinase 3 antibody; MAP kinase kinase 3 antibody; map2k3 antibody; MAPK ERK kinase 3 antibody; MAPK/ERK kinase 3 antibody; MAPKK 3 antibody; MAPKK3 antibody; MEK 3 antibody; MEK3 antibody; Mitogen activated protein kinase kinase 3 antibody; MKK 3 antibody; MKK3 antibody; mMKK3b antibody; MP2K3_HUMAN antibody; PRKMK 3 antibody; PRKMK3 antibody; protein kinase, mitogen-activated, kinase 3 antibody; SAPK kinase 2 antibody; SAPKK 2 antibody; SAPKK2 antibody; Stress activated protein kinase kinase 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Human MEK-3 around the phosphorylation site of T222.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.
  • 基因功能參考文獻:
    1. Advanced glycation end products significantly activated ASK1, MKK3, and MKK6, which led to activation of p38 MAPK, resulting in upregulated fibrotic response in human coronary smooth muscle cells. PMID: 30305582
    2. The study identifies MKK3 as a negative regulator of mitochondrial function and inflammatory responses to cigarette smoke and suggests that MKK3 could be a therapeutic target. PMID: 27717867
    3. High MKK3 expression is associated with lung cancer. PMID: 28628118
    4. miR-21 targets MKK3 in vivo and in vitro, inhibiting the downstream factors IL-6 and TNF-alpha, in ischemia pretreatment protection from ischemia-reperfusion induced kidney injury. PMID: 26149640
    5. MKK3 overexpression upregulated the cyclin-dependent kinase inhibitors, p16 INK4A and p15 INK4B in hepatocellular carcinoma cells was Bim1, was downregulated following MKK3 overexpression. PMID: 26573508
    6. Our results suggest that asthma is associated with MKK3 over-expression in CD8+ cells; we have also demonstrated that MKK3 may be critical for airway neutrophilia PMID: 24480516
    7. MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen-activated protein kinase-kinase 3. PMID: 24112539
    8. study detected higher MKK3 activation in isolated peripheral blood mononuclear cells from septic patients compared with nonseptic controls PMID: 24487387
    9. study concludes MAP2K3 is a reproducible obesity locus that may affect body weight via complex mechanisms involving appetite regulation and hypothalamic inflammation PMID: 23825110
    10. miR-20a acts in a feedback loop to repress the expression of MKK3 and to negatively regulate the p38 pathway-mediated VEGF-induced endothelial cell migration and angiogenesis PMID: 22696064
    11. the balance between MKK6 and MKK3 mediates p38 MAPK associated resistance to cisplatin in NSCLC PMID: 22164285
    12. LFA-1-induced stabilization of ARE-containing mRNAs in T cells is dependent on HuR, and occurs through the Vav-1, Rac1/2, MKK3 and p38MAPK signaling cascade PMID: 21206905
    13. MAP2K3 is identified as a protein to promote senescence in human breast epithelial cells. PMID: 21137025
    14. Data provide evidence that p38 Map kinase (MAPK) pathway is activated leading to increased upregulation of mixed lineage kinase 3, MKK3/6, MSK1, and Mapkapk2, upon treatment of BCR/ABL expressing cells with dasatinib. PMID: 19672773
    15. role in activating Mirk protein kinase PMID: 11980910
    16. interacts with phospholipase c-beta 2 PMID: 12054652
    17. role in pathway that promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells PMID: 12377770
    18. TAK1- and MKK3-mediated activation of p38 are facilitated by Smad7 PMID: 12589052
    19. MKK3 is selectively activated by the new subfamily of Ste20-like kinases. PMID: 13679851
    20. a specific requirement for p150(Glued)/dynein/functional microtubules in activation of MKK3/6 and p38 MAPKs in vivo. PMID: 15375157
    21. MAP kinase kinase3- and 6-dependent activation of the alpha-isoform of p38 MAP kinase is required for the cytoskeletal changes induced by neutrophil adherence and influences subsequent neutrophil migration toward endothelial cell junctions PMID: 15516490
    22. H-Ras-specific activation of Rac-MKK3/6-p38 pathway has a role in invasion and migration of breast epithelial cells PMID: 15677464
    23. MKK3 and MKK6 make individual contributions to p38 activation in fibroblast-like synoviocytes after cytokine stimulation PMID: 15778394
    24. p38 mediates EGF receptor activation after oxidant injury; Src activates MMK3, which, in turn, activates p38; and the EGF receptor signaling pathway plays a critical role in renal epithelial cell dedifferentiation PMID: 15797859
    25. Bax is phosphorylated by stress-activated JNK and/or p38 kinase and phosphorylation of Bax leads to mitochondrial translocation prior to apoptosis PMID: 16709574
    26. Mitogen-activated protein kinase (MAPK) kinase 3 (MKK3) is a key activator of p38 MAPK in glioma; MKK3 activation is strongly correlated with p38 activation in vitro and in vivo. PMID: 17406030
    27. Cytokine activation of MAPK14 and apoptosis is opposed by ACTN4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3. PMID: 17438131
    28. as a mediator of SF- and Src-stimulated NF-kappaB activity. Finally, the Src/Rac1/MKK3/6/p38 and Src/TAK1/NF-kappaB-inducing kinase pathways exhibited cross-talk at the level of MKK3. PMID: 19047046

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Defects in MAP2K3 may be involved in colon cancer.
  • 蛋白家族:
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
  • 組織特異性:
    Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
  • 數據庫鏈接:

    HGNC: 6843

    OMIM: 602315

    KEGG: hsa:5606

    STRING: 9606.ENSP00000345083

    UniGene: Hs.514012



主站蜘蛛池模板: 中文字幕久久久久人妻中出| 人妻老妇乱子伦精品无码专区| 99这里有精品视频视频| 亚洲国产精品无码久久sm| 久久婷婷五月综合鬼色| 日日摸天天爽天天爽视频| 国产成人精品一区二三区在线观看| 久久久久久人妻一区精品| 夜色约爱网站| 天堂在/线资源中文在线8| 2019一級特黃色毛片免費看| 上司人妻互换中文字幕| 在线播放无码高潮的视频| 先锋影音xfyy5566男人资源| 2020年最新国产精品正在播放| 久久大香线蕉国产精品免费| 夜夜高潮天天爽欧美| 国产激情久久久久久熟女老人 | 色综久久综合桃花网国产精品| 亚洲精品专区成人网站| 亚洲成av人片在线观看不卡| 熟妇人妻系列av无码一区二区| 国产在线 | 中文| 一边捏奶头一边啪高潮视频 | 国产三级视频在线播放线观看| 欧美一区二区三区红桃小说| 人妻少妇精品中文字幕av| 丰满大爆乳波霸奶| 99久久国产亚洲高清观看| 人妻熟妇乱又伦精品hd| 乌克兰少妇videos高潮| 人妻少妇偷人精品无码| 国产高清乱码又大又圆| 亚洲一二区制服无码中字| 欧美人与性动交α欧美精品| 成人片黄网站色大片免费| 国产国拍精品av在线观看| 国产免费人成网站x8x8| 亚洲人成人77777网站| 天天摸夜夜摸夜夜狠狠摸| 永久免费观看美女裸体的网站|