在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-LIMK2 (T505) Antibody

  • 中文名稱:
    磷酸化-LIMK2 (T505)兔多克隆抗體
  • 貨號:
    CSB-PA000567
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of 293 cells using Phospho-LIMK-2 (T505) Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    LIM domain kinase 2 antibody; LIM kinase 2 antibody; LIMK 2 antibody; LIMK-2 antibody; Limk2 antibody; LIMK2_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Human LIMK-2 around the phosphorylation site of T505.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1.
  • 基因功能參考文獻:
    1. High LIMK2 expression is associated with alcoholic hepatitis. PMID: 28818508
    2. these results suggested that TUG1 mediates cell growth and chemoresistance of SCLC by regulating LIMK2b via EZH2. PMID: 28069000
    3. LIMK2 (rs149034313) is associated with Behcet's disease. The LIMK2 association is a missense variant with predicted protein damage that may influence functional interactions with proteins involved in cytoskeletal regulation by Rho GTPase, inflammation mediated by chemokine and cytokine signaling pathways, T cell activation, and angiogenesis. PMID: 26662719
    4. We observed marked increases in LIM kinase 2 (LIMK2) and cofilin 1 (CFL1) gene expressions in metabolic syndrome patients. PMID: 26956845
    5. This study showed that LIMK2 messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples. PMID: 25981171
    6. Actin remodelling factor LIMK2 is a key player in the ciliogenesis control network in which YAP/TAZ and directional vesicle trafficking are integral components. PMID: 25849865
    7. results highlight the exciting possibility of combining specific LIMK2 inhibitors with anticancer drugs in the treatment of multi-drug resistant cancers PMID: 23991158
    8. LIMK2 expression was reduced in intestinal tumours of cancer-prone mice and in human colorectal cancer cell lines and tumours. LIMK2 expression progressively decreased with advancing stage of colorectal cancer. PMID: 23585469
    9. Overexpression of LIMK2 is associated with breast cancer growth and invasiveness. PMID: 23239465
    10. Nf1/LIMK2 interaction and inhibition allows to directly connect neurofibromatosis type I to actin cytoskeleton remodeling. PMID: 23082153
    11. LIMK2 is a key regulator that acts through different substrates to provide functional links between the actin cytoskeleton and spindle dynamics. PMID: 22328514
    12. LIMK2 positively regulates the level of Aurora A, thereby engaging in a positive-feedback loop, promoting Aurora-A-mediated oncogenic pathways. PMID: 22492986
    13. LIMK2 variant isoforms were found to be regulated by p53 through direct interaction with regulatory elements within the LIMK2 gene. PMID: 21079653
    14. a novel pathway whereby LIMK2b, acting downstream of p53, ensures proper execution of checkpoint arrest by modulating the dynamics of actin polymerization PMID: 20190821
    15. a novel pathway emanating from the TGF-beta type I receptor and leading to regulation of actin assembly, via the kinase LIMK2. PMID: 15647284
    16. PKC-mediated exclusion of LIMK2 from the nucleus might be a mechanism to relieve suppression of cyclin D1 expression by LIMK2 PMID: 15923181
    17. LIMK2 may play a role different from that of LIMK1 in regulating mitotic spindle organization, chromosome segregation, and cytokinesis during the cell division cycle. PMID: 16455074
    18. analysis of phosphorylation-dependent regulation of unique nuclear and nucleolar localization signals of LIM kinase 2 in endothelial cells PMID: 16820362
    19. direct interaction between ROCK1 and LIMK2 in polarised but not blebbing cells; results point to a specific role for the ROCK1:LIMK2 pathway in mesenchymal-mode migration PMID: 18852895

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.; [Isoform LIMK2a]: Cytoplasm. Nucleus.; [Isoform LIMK2b]: Cytoplasm. Cytoplasm, perinuclear region. Nucleus.
  • 蛋白家族:
    Protein kinase superfamily, TKL Ser/Thr protein kinase family
  • 數據庫鏈接:

    HGNC: 6614

    OMIM: 601988

    KEGG: hsa:3985

    STRING: 9606.ENSP00000339916

    UniGene: Hs.474596



主站蜘蛛池模板: 99久久国产露脸精品国产麻豆| 精品综合久久久久久98| 亚洲午夜无码久久yy6080| 精品无码成人网站久久久久久| 国产ww久久久久久久久久| 狠狠色狠狠色综合日日不卡| 国产a三级久久精品| 人妻 偷拍 无码 中文字幕| 把插八插露脸对白内射| 少妇人妻偷人精品视蜜桃| 国产又色又爽又黄好看的视频| 亚洲日韩看片无码超清| 人妻精品动漫h无码中字| 2019nv天堂香蕉在线观看| 久久精品国产99国产精2020丨| 麻豆专媒体一区二区| 国产激情一区二区三区| 亚洲成av人在线视| 欧美成人精品福利视频| 久久精品人人做人人爽97| 丰满熟妇乱又伦| 欧美大肥婆大肥bbbbb| 丰满多毛的陰户视频| 在线 | 国产精品星空传媒丿| 久久久久无码国产精品不卡| 成人爱做日本视频免费| 永久免费无码av在线网站| 一本一道久久a久久精品综合| 三级视频兔费看| 国产福利日本一区二区三区| 2020精品国产户外| 亚洲日韩中文字幕无码一区| 国产精品爱啪在线播放| 又爽又黄无遮挡高潮视频网站| 亚洲精品午夜一区人人爽| 免费国产线观看免费观看| 奇米影视第4色| 欧美毛多水多黑寡妇| 伊人中文字幕无码专区| 国产成人午夜高潮毛片| 日日噜噜夜夜狠狠久久无码区 |