在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. Phospho-GRIA4 (S862) Antibody

Phospho-GRIA4 (S862) Antibody

  • 中文名稱：
    磷酸化-GRIA4 (S862)兔多克隆抗體
  • 貨號(hào)：
    CSB-PA008958
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    AMPA 4 antibody; AMPA selective glutamate receptor 4 antibody; AMPA-selective glutamate receptor 4 antibody; AMPA4 antibody; GluA 4 antibody; GluA4 antibody; GluR 4 antibody; GluR D antibody; GluR-4 antibody; GluR-D antibody; GluR4 antibody; GLUR4C antibody; GLURD antibody; Glutamate receptor 4 antibody; Glutamate receptor ionotrophic AMPA 4 antibody; Glutamate receptor ionotropic antibody; GRIA 4 antibody; Gria4 antibody; GRIA4_HUMAN antibody; Ionotropic Glutamate receptor 4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human GluR4 around the phosphorylation site of S862.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
  • 基因功能參考文獻(xiàn)：
    1. The authors suggest that pathogenic de novo variants in GRIA4 lead to intellectual disability with or without seizures, gait abnormalities, problems of social behavior, and other variable features. PMID: 29220673
    2. Study shows that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluA4 is expressed on oligodendrocytes, myelin and on axons in humans. PMID: 27443784
    3. This study demonstrated that the GRIA4 protein was altered in auditory cortex patient with schizophreia. PMID: 25433904
    4. Interaction with the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR4. PMID: 24962026
    5. Did not observed any significant association between GRIA4 polymorphisms and clinical improvement in patients with Major depressive disorder. PMID: 22057216
    6. SNPs within GRIA4 may not be associated with the development and treatment outcomes in BD PMID: 22122651
    7. No significant association GRIA4 polymorphisms was found with the diagnosis of schizophrenia. PMID: 22094384
    8. characterization of homomeric alpha-amino-3-hydroxy-5-methylisoxazolepropionate (AMPA)-selective GluR-D glutamate receptors carrying N-terminal deletions PMID: 12393905
    9. Results suggest that at least one susceptibility locus for schizophrenia is located within or very close to the GRIA4 region in Japanese. PMID: 12497607
    10. alternative splicing isoform of GluR4, human GluR4c has a 113-bp insert containing a stop codon, resulting in a short C terminus. PMID: 15306133
    11. The minimal kinetic mechanism for channel opening is consistent with binding of two glutamate molecules per receptor complex. PMID: 15823042
    12. GluR4 may regulate its synaptic targeting through phosphorylation-dependent interactions with alpha-Actinin-1 and IQGAP1 PMID: 16190873
    13. The present findings show that the interaction between PKCgamma and GluR4 is specifically required to assure PKC-driven phosphorylation and surface membrane expression of GluR4. PMID: 17233759

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, GRIA4 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4574

    OMIM: 138246

    KEGG: hsa:2893

    STRING: 9606.ENSP00000282499

    UniGene: Hs.503743



主站蜘蛛池模板： 国产亚洲va在线电影| 国产成人久久a免费观看| 免费全部高h视频无码| 国产精品欧美久久久久无广告| 国产成人毛片在线视频| 亚洲 欧美 日韩 综合aⅴ| 国产乱了真实在线观看| 久久亚洲中文无码咪咪爱| 欧美三级在线播放线观看| 亚洲午夜未满十八勿入网站| 国产亚洲情侣一区二区无| 18禁男女污污污午夜网站免费暖暖| 偷柏自拍亚洲综合在线| 欧美疯狂做受xxxx高潮| 亚洲 自拍 另类小说综合图区| 精品国产福利在线视频| 国产精品久久久久影院色| 久久中文字幕人妻熟av女| 国产后进白嫩翘臀在线播放| 十八禁午夜福利免费网站| 印度女人狂野牲交| 亚洲中文字幕无码一区二区三区 | 成在人线av无码免观看| 手机在线亚洲国产精品| 99热在线观看| 欧美日韩一区二区成人午夜电影| 午夜福利视频极品国产83| 伊人久久大香线蕉无码不卡| 俺去俺来也在线www色官网 | 久久久无码精品国产一区| 老熟妇性老熟妇性色| 国产精品人妻一区夜夜爱| 久久综合给合久久狠狠狠88| 天堂网在线www中文| 国产精品久久一区二区三区| yy6080久久伦理一区二区| 亚洲va在线va天堂va欧美va| 成人精品天堂一区二区三区| 无码人中文字幕| 97se狠狠狠狠狼鲁亚洲综合色| 亚洲а∨精品天堂在线|