在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. Phospho-CAV2 (Tyr27) Antibody

Phospho-CAV2 (Tyr27) Antibody

  • 中文名稱：
    磷酸化-CAV2 (Tyr27)兔多克隆抗體
  • 貨號：
    CSB-PA946051
  • 規格：
    ￥2454
  • 圖片：
    • Western blot analysis of extracts from cos-7 cells (Lane 2), using Caveolin 2 (Phospho-Tyr27) Antibody. The lane on the left is treated with antigen-specific peptide.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CAV2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Peptide sequence around phosphorylation site of tyrosine 27 (L-E-Y(p)-A-D) derived from Human Caveolin 2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
  • 基因功能參考文獻：
    1. Cav-2beta isoform yielded by alternative translation initiation desensitizes insulin receptor (IR) via dephosphorylation by PTP1B, and subsequent endocytosis and lysosomal degradation of IR, causing insulin resistance. PMID: 29604334
    2. Results verified the presence of transcript III of cav-2 for the first time, but no protein associated was found. Also, a decreasing trend of cav-2 (transcripts I and II) were observed in tumoral tissues especially in stages I and II and seem to be associated with the incidence and promotion of breast cancer, especially in the initial stages of breast cancer. PMID: 28857238
    3. High CAV2 expression is associated with lung cancer. PMID: 26930711
    4. A-type lamin-dependent Caveolin-2 homo-oligomerization in the inner nuclear membrane microdomain is a precondition for pY19-Caveolin-2-mediated insulin-response epigenetic activation at the nuclear periphery. PMID: 27552914
    5. Caveolin-2 expression is necessary for the control of E2-dependent cellular proliferation of MCF-7 cells. PMID: 26480297
    6. variant in CAV2 is associated with increased age-of-onset of P. aeruginosa airway infection in cystic fibrosis cohort. PMID: 26047157
    7. Results present initial characterization of key proteins Cav2 and CFL1 as cellular factors that colocalize with M in viral inclusions and filaments and ZNF502 protein which appears to interact with RSV M in the nucleus. PMID: 25556234
    8. Our findings did not correspond with previous positive results, suggesting that CAV1-CAV2 variants studied in the present study are not important risk factors for Normal Tension Glaucoma. PMID: 23743525
    9. This study does not support an association between CAV2 variation and kidney transplant survival. PMID: 23667606
    10. The combination of the expression of the genes for PPARgamma, STMN1 and CAV2 was significantly predictive for early recurrence of non-muscle-invasive bladder cancer PMID: 21489836
    11. In contrast to wild-type-Cav-2, retroviral re-expression of Y19/27F-Cav-2 in Cav-2 knockout endothelial cells did not affect anti-proliferative effect of TGF-beta compared to empty vector. PMID: 22819829
    12. Stromal caveolin-2 expression were more frequent in anaplastic carcinoma and diffuse sclerosing variant of papillary carcinoma compared to conventional papillary thyroid carcinoma. PMID: 22236542
    13. CAV1 mRNA and protein levels are reduced by both NFBD1 knockdown and knockout independently of IR and p53 PMID: 21551225
    14. cav-2 acts as a modulator of cancer progression. PMID: 21373752
    15. We found preliminary evidence that CAV2 rs2270188 interacts with dietary fat to affect risk of type 2 diabetes. PMID: 21178094
    16. Single Nucleotide Polymorphisms in CAV2 is associated with primary open-angle glaucoma. PMID: 20835238
    17. In Caco-2 cells, a polarized cell line derived from human colon cancer that does not express caveolin 1 (Cav-1), there was no detectable expression of caveolin 2 (Cav-2). PMID: 12414992
    18. caveolin-2 may play a role in lamellar granule assembly, trafficking, and/or function. PMID: 12648214
    19. PPARgamma ligands increased the levels of caveolin-2 2-5-fold in a concentration-dependent manner within 24 h. Nonthiazolidinedione PPARgamma ligands elevated caveolin-2 protein 3-4-fold. PMID: 12813462
    20. New evidence demonstrating that Cav-2 undergoes phosphorylation at both tyrosines 19 and 27 also reveals that tyrosine phosphorylation of Cav-2 has no effect on its targeting to lipid rafts, but clearly disrupts hetero-oligomerization of Cav-2 with Cav-1. PMID: 15504032
    21. Heterologously and endogenously expressed D1 dopamine receptors in renal cells are associated with and regulated by caveolin-2. PMID: 15569306
    22. Overexpression of caveolin-2 is associated with inflammatory breast cancer PMID: 16244790
    23. CAV2 identified and immunolocalized in the caveola-vesicle complexes (CVC )present in erythrocytes infected with P. vivax PMID: 16521037
    24. Caveolin-2 was expressed in the sinusoidal endothelial cells and the smooth muscle cells of the unparied arteries of hepatpcellular carcinoma specimens. PMID: 17898556
    25. CAV2 is preferentially expressed in basal-like cancers and is associated with poor prognosis PMID: 17912630
    26. Data suggests a possible involvement of serine 36-phosphorylated caveolin-2 in modulating mitosis. PMID: 18081315

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.
  • 蛋白家族：
    Caveolin family
  • 組織特異性：
    Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.
  • 數據庫鏈接：

    HGNC: 1528

    OMIM: 601048

    KEGG: hsa:858

    STRING: 9606.ENSP00000222693

    UniGene: Hs.212332



主站蜘蛛池模板： 手机看片久久国产免费| 性色av一区二区三区无码| 日韩人妻一区二区三区免费| 日本新janpanese乱熟| 爽死你欧美大白屁股在线| 欧美肥胖老太vidio在线视频| 在线观看国产日韩亚洲中| 日产a一a区二区www| 浴室人妻的情欲hd三级国产| 久久这里只有精品首页| 国产av国片偷人妻麻豆| 欧美丰满肥婆videos| 麻豆国产成人av在线播放欲色| 国内极度色诱视频网站| 黄桃av无码免费一区二区三区| 亚洲成av人片在线观看无码不卡 | 日韩精品一卡2卡三卡4卡| 最新国产精品精品视频| 日本日本熟妇中文在线视频| 国产成人av男人的天堂| 亚洲欧美一区二区三区日产| 亚洲性夜夜天天天| 国产欧美日韩综合在线成| 又黄又爽的60分钟视频| 成人无码免费一区二区三区| 成人免费看吃奶视频网站| 日本十八禁黄无遮禁视频免费| 欧美精品v欧洲精品| 国外亚洲成av人片在线观看| 日本sm/羞辱/调教/捆绑视频| 欧美成人精品三级一二三在线观看| 国内精品久久久久久久影院| 国产日产精品一区二区三区四区的特点 | 亚洲中文字幕无码久久2020| 无码熟妇人妻av在线网站| 中文天堂资源在线www| а天堂中文官网| 无码少妇一区二区浪潮免费| 国产精品va在线观看h| 中文字幕亚洲欧美日韩在线不卡| 日日摸天天摸爽爽狠狠97|