在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PVRL2 Antibody

  • 中文名稱:
    PVRL2兔多克隆抗體
  • 貨號:
    CSB-PA019096GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CD 112 antibody; CD112 antibody; CD112 antigen antibody; Herpes virus entry mediator B antibody; Herpes virus entry protein B antibody; Herpesvirus entry mediator B antibody; Herpesvirus entry protein B antibody; Hve B antibody; HveB antibody; Nectin-2 antibody; Nectin2 antibody; Poliovirus receptor like 2 antibody; Poliovirus receptor related 2 (herpesvirus entry mediator B) antibody; Poliovirus receptor related 2 antibody; Poliovirus receptor related protein 2 antibody; Poliovirus receptor-related protein 2 antibody; PRR 2 antibody; PRR2 antibody; PVRL 2 antibody; PVRL2 antibody; PVRL2_HUMAN antibody; PVRR 2 antibody; PVRR2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Human PVRL2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein.; (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).
  • 基因功能參考文獻:
    1. Nectin-2 mutation in men with severe teratospermia PMID: 28689229
    2. In the infection with 3 MLD50 (50 % mouse lethal dose), effective resistance was not observed in transgenic mice expressing nectin-2Ig. PMID: 28671524
    3. Our data provide important structural and biochemical determinants responsible for the recognition of nectin-2 by TIGIT. PMID: 27978489
    4. Chromosomal breakpoints involved the PVRR2 gene in 19q31 is associated with Diffuse Large B-Cell Lymphomas. PMID: 27356265
    5. energetic basis for the TIGIT/nectin-2 interaction and revealed that an "aromatic key" of nectin-2 is critical for this interaction, whereas variations in the lock were tolerated. PMID: 28515320
    6. PVRL2 is a plasma cholesterol-responsive gene acting at endothelial sites of vascular inflammation to regulate transendothelial migration of leukocytes. PMID: 28062492
    7. Serum levels of nectin-2 may have diagnostic roles for colorectal cancer patients. PMID: 26184725
    8. Soluble form of nectin-2 is required for exerting the resistance against HSV-2 infection. PMID: 26982466
    9. PVRL2, TOMM40 and APOE might be associated with human longevity. PMID: 24924924
    10. Nectin-3 trans-interacts with Nectin-2 to promote lymphocyte and monocyte extravasation. PMID: 24116228
    11. Chorionic gonadotropin induces vascular endothelial growth factor (VEGFA)-dependent downregulation of nectin 2, which increases the endothelial permeability in the coculture system. PMID: 23465821
    12. Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion. PMID: 22927415
    13. a possible etiologic role of PRR2 in nonsyndromic cleft lip with or without cleft palate PMID: 20662561
    14. The CD112 is highly expressed in colon carcinoma tissues and cell lines. PMID: 20617580
    15. The authors now show that human cytomegalovirus targets CD112 for proteasome-mediated degradation by 48 h post-infection, thus removing both activating ligands for DNAM-1 from the cell surface during productive infection. PMID: 20410314
    16. differences in the N termini of herpes simplex virus type 1 and 2 gDs that influence functional interactions with the human entry receptor Nectin-2 PMID: 12915581
    17. There is an allelic association of sequence variation in PVRL2 and the severity of multiple sclerosis. PMID: 16738668
    18. CD226/CD112 (DNAM-1/Nectin-2) mast cell stimulation has a role in the allergic process PMID: 16831868
    19. identified PVRL2 as a new recurrent partner gene of the TRA@ locus in peripheral T-cell lymphoma PMID: 17696193
    20. Crystallization and preliminary X-ray analysis of the V domain of human nectin-2 are reported. PMID: 19478445
    21. Regions of nectin-2 protein important for herpesvirus entry activity and homotypic nectin-nectin interactions are overlapping but not identical. PMID: 12438620

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Nectin family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 9707

    OMIM: 600798

    KEGG: hsa:5819

    STRING: 9606.ENSP00000252483

    UniGene: Hs.655455



主站蜘蛛池模板: 国产美女牲交视频| 曰本丰满熟妇xxxx性| 人妻少妇邻居少妇好多水在线| 香蕉噜噜噜噜私人影院| 他用舌头给我高潮喷水在线| 色综合视频一区二区三区44| 西西人体大胆午夜视频| 国产白袜脚足j棉袜在线观看| www国产内插视频| 一本大道久久香蕉成人网| 欧美人成精品网站播放| 国产精品av在线| 亚洲日本中文字幕天天更新| 国产xxxx69真实实拍| a毛片免费全部播放自慰| 最新777第四色米奇影视| 精品国产天线2019| 日韩超碰人人爽人人做人人添| 猫咪www免费人成网站无码| 亚洲中文有码字幕青青| 免费1级做爰片在线观看爱| 国产成人av一区二区三区在线观看 | 亚洲人精品亚洲人成在线| 日本50岁丰满熟妇xxxx| 又黄又爽又猛的视频免费| 特级a欧美做爰片三人交| 亚洲精品少妇高清30p| 免费女人高潮流视频在线观看| 51国偷自产一区二区三区| 亚洲最大日夜无码中文字幕| 中文字幕无码专区人妻系列| 国产真实乱对白精彩久久| 日韩大片高清播放器| 丰满大爆乳波霸奶| 久久久女人与动物群交毛片| 精品一区二区三区自拍图片区| √最新版天堂资源网在线| 久久久久成人片免费观看r| 人妻激情乱人伦| 亚洲熟妇少妇任你躁在线观看无码| 朝鲜女人大白屁股ass|