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PUS1 Antibody

  • 中文名稱:
    PUS1兔多克隆抗體
  • 貨號(hào):
    CSB-PA019086GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    PUS1
  • 別名:
    A730013B20Rik antibody; DOBI antibody; MGC112655 antibody; MGC11268 antibody; MLASA antibody; MLASA1 antibody; mPus1p antibody; Pseudouridine synthase 1 antibody; Pseudouridylate synthase 1 antibody; PUS1 antibody; tRNA pseudouridine synthase A, mitochondrial antibody; tRNA pseudouridine(38-40) synthase antibody; tRNA pseudouridylate synthase I antibody; tRNA uridine isomerase I antibody; tRNA-uridine isomerase I antibody; TRUA_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PUS1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 RNA.
  • 基因功能參考文獻(xiàn):
    1. results show that the NTD of ERalpha and AR contains a novel RBM that directly binds SRA, and that STR5 can serve as a novel class of RNA inhibitor of ERalpha and AR signaling by interfering with Pus1p-mediated SRA pseudouridylation PMID: 22998747
    2. Investigation of the sequence and structural requirements for hPus1p activity on human tRNASer. PMID: 22102571
    3. We identified one novel homozygous null mutation in a familial case. It predicts a nonsense mutation at glutamine 154 (Q154X) that would lead to a protein lacking the 266 C-terminal amino acids PMID: 19731322
    4. Missense mutation in pseudouridine synthase 1 causes mitochondrial myopathy and sideroblastic anemia PMID: 15108122
    5. MLASA is associated with absent or greatly reduced tRNA pseudouridylation at specific sites, implicating this pathway in its molecular pathogenesis. PMID: 15772074
    6. A new homozygous stop mutation (E220X)predicts a protein missing 208/427 amino acid residues on the C terminus. The nuclear isoform has an N-terminal extension absent in the mature mitochondrial isoform. PMID: 17056637
    7. Three residues (R116, Y173, R267) that correspond to amino acids known to compose the active site of TruA, a bacterial Psi synthase that is homologous to Pus1p, were mutated in human Pus1p. PMID: 18648068

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  • 相關(guān)疾?。?/div>
    Myopathy with lactic acidosis and sideroblastic anemia 1 (MLASA1)
  • 亞細(xì)胞定位:
    [Isoform 1]: Mitochondrion.; [Isoform 2]: Nucleus.
  • 蛋白家族:
    TRNA pseudouridine synthase TruA family
  • 組織特異性:
    Widely expressed. High levels of expression found in brain and skeletal muscle.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 15508

    OMIM: 600462

    KEGG: hsa:80324

    STRING: 9606.ENSP00000365837

    UniGene: Hs.592004



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