在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PUM2 Antibody

  • 中文名稱:
    PUM2兔多克隆抗體
  • 貨號:
    CSB-PA019082GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    FLJ36528 antibody; KIAA0235 antibody; MGC138251 antibody; MGC138253 antibody; PUM 2 antibody; PUM2 antibody; PUM2_HUMAN antibody; PUMH 2 antibody; PUMH2 antibody; Pumilio (Drosphila) homolog 2 antibody; Pumilio homolog 2 (Drosophila) antibody; Pumilio homolog 2 antibody; Pumilio-2 antibody; Pumilio2 antibody; PUML2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PUM2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation. Plays a role in cytoplasmic sensing of viral infection. Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm. May regulate DCUN1D3 mRNA levels. May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level.
  • 基因功能參考文獻:
    1. PUM2 suppresses osteosarcoma progression via partly and competitively binding to STARD13 3'UTR with miRNAs PMID: 30084199
    2. A recent paper by the Mendell group identifies NORAD, a novel lncRNA that is regulated in response to DNA damage and plays a key role in maintaining genome integrity by modulating the activity the RNA binding proteins PUM2 and PUM1. PMID: 27157388
    3. results reveal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1/2 and FOXP1 in regulating normal hematopoietic stem/progenitor cell and leukemic cell growth. PMID: 28232582
    4. The study shows that pseudouridine and N(6)-methyladenosine weaken the binding of the human single-stranded RNA binding protein Pumilio 2 (hPUM2) to its consensus motif. PMID: 28138061
    5. Pumilios (including PUM1 and PUM2) are RNA-binding proteins with Puf domains made up of 8 poorly conserved Puf repeats, 3 helix bundles arranged in rainbow architecture, where each repeat recognizes a single base of the RNA-binding sequence. [REVIEW] PMID: 26517885
    6. Identification of NORAD-interacting proteins revealed that this lncRNA functions as a multivalent binding platform for PUM proteins, with the capacity to sequester a significant fraction of the total cellular pool of PUM1 and PUM2. Studies reveal unanticipated roles for a lncRNA and PUMILIO proteins in the maintenance of genomic stability. PMID: 26724866
    7. PUM2 does not repress differentiation of adipose-derived stem cells (ASCs) but rather is involved in the positive control of ASCs division and proliferation. PMID: 21649561
    8. human Pumilio homologs Pum 1 and Pum 2 repress the translation of E2F3 by binding to the E2F3 3' untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting microRNAs (miRNAs) PMID: 22345517
    9. Mammalian PUM2-Ago-eEF1A inhibited translation of nonadenylated and polyadenylated reporter mRNAs in vitro. PMID: 22231398
    10. in mitosis, PUM2 physically associates with Aurora-A to ensure enough active Aurora-A at centrosomes for mitotic entry PMID: 21589936
    11. Three distinct modes of target RNA binding by PUM2 around the fifth mRNA base were observed. PMID: 21397187
    12. PUM2 as a component of conserved cellular machinery that may be required for germ cell development. PMID: 12511597
    13. PUM2 and DAZL, are capable of binding the same mRNA sequences in the 3'UTR of human SDAD1 mRNA. PMID: 15607425
    14. P2P-R expression may be translationally regulated by PUM2 PMID: 15617101
    15. PUMILIO mediated translational regulation may be universally used in developmental processes of the human body. PMID: 16967088
    16. Variation in the PUMILIO2 gene is very low and it seems improbable that mutations of this gene significantly contribute to male infertility in humans. PMID: 17154300
    17. Data found that PUMILIO2 interacts also with SNAPIN, a modulator of SNARE complex assembly, which is involved in vesicle trafficking. PMID: 19168546

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cytoplasmic granule. Cytoplasm, perinuclear region.
  • 組織特異性:
    Expressed in male germ cells of adult testis (at protein level). Highly expressed in testis and ovary. Predominantly expressed in stem cells and germ cells. Expressed at lower level in brain, heart, kidney, liver, muscle, placenta, intestine and stomach E
  • 數據庫鏈接:

    HGNC: 14958

    OMIM: 607205

    KEGG: hsa:23369

    STRING: 9606.ENSP00000338173

    UniGene: Hs.467824



主站蜘蛛池模板: 欧美乱色伦图片区| 性欧美丰满熟妇xxxx性| 亚洲日韩欧洲乱码av夜夜摸 | 久久久久麻豆v国产精华液好用吗 99久久人妻精品免费一区 | 日本三级欧美三级人妇视频| 久久久久av无码免费网| 人妻中文字幕无码专区| 在线播放无码后入内射少妇| 日本少妇xxx做受| av在线 亚洲 天堂| 妺妺窝人体色www在线下载| 久久99亚洲网美利坚合众国| 成熟女人特级毛片www免费| 777午夜精品免费观看| 97精品人妻系列无码人妻| 三上悠亚精品一区二区久久| 日韩亚洲国产综合高清| 欧美性白人极品1819hd| 日日澡夜夜澡人人高潮| 亚洲国产人成自精在线尤物| 亚洲国产欧美在线观看片不卡| 特级毛片内射www无码| 成人精品视频99在线观看免费 | 亚洲人成电影网站色www两男一女| 精品无码一区二区三区电影 | 99久久99视频只有精品| 少妇无码一区二区三区免费| 精品一区二区三区免费播放| 一本大道一卡2卡三卡4卡国产| 人成午夜免费大片| 久久久久成人精品| 性生交大片免费看l| 自拍偷亚洲产在线观看| 在线观看特色大片免费视频| av色欲无码人妻中文字幕| 色8激情欧美成人久久综合电影| 草草网站影院白丝内射| 久久精品午夜福利| 久章草在线精品视频免费观看| 亚洲精品无码mv在线观看网站| 国产sm重味一区二区三区 |