在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PTPRS Antibody, FITC conjugated

PTPRS Antibody, FITC conjugated

  • 中文名稱：
    PTPRS兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA613393LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PTPRS Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Protein tyrosine phosphatase PTPsigma antibody; Protein tyrosine phosphatase receptor type S antibody; Protein tyrosine phosphatase receptor type sigma antibody; Ptprs antibody; PTPRS_HUMAN antibody; PTPSIGMA antibody; R PTP sigma antibody; R-PTP-S antibody; R-PTP-sigma antibody; Receptor-type tyrosine-protein phosphatase S antibody; Receptor-type tyrosine-protein phosphatase sigma antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Receptor-type tyrosine-protein phosphatase S protein (25-128AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.
  • 基因功能參考文獻：
    1. Study identified several CpG sites and specifically several CpGs in the PTPRS and PER3 genes differentially methylated between obese and non-obese children, suggesting a role for DNA methylation concerning development of childhood obesity. PMID: 28614626
    2. interaction of receptor type of protein tyrosine phosphatase sigma (RPTPsigma) with a glycosaminoglycan library PMID: 29420785
    3. Receptor protein tyrosine phosphatase sigma (RPTPsigma) regulates neuronal extension and acts as a presynaptic nexus for multiple protein and proteoglycan interactions during synaptogenesis. PMID: 25385546
    4. Data demonstrate that synoviocytes are regulated by an RPTPsigma-dependent proteoglycan switch in vivo, which can be targeted for rheumatoid arthritis therapy. PMID: 25995222
    5. represents an evolutionarily conserved pDC-specific inhibitory receptor, and is required to prevent spontaneous IFN production and immune-mediated intestinal inflammation PMID: 26231120
    6. crystallographic analyses of a shared HSPG-CSPG binding site reveal a conformational plasticity that can accommodate diverse glycosaminoglycans with comparable affinities; HS and analogs induced RPTPsigma ectodomain oligomerization which was inhibited by CS PMID: 21454754
    7. Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma. PMID: 22027896
    8. Intragenic microdeletions of the EGFR phosphatase PTPRS were found frequently (26%) in head and neck cancers, identifying this gene as a target of 19p13 loss. PMID: 22065749
    9. Transgenic zebrafish carrying a promoter-driven expression vector reveal the increased density of olfactory sensory neuron-specific cell synapses. PMID: 21812780
    10. Data show that PTPsigma localizes to PtdIns3P-positive membranes in cells, and this vesicular localization is enhanced during autophagy. PMID: 21303930
    11. The receptor protein tyrosine phosphatase sigma (RPTPsigma) has now been identified as a receptor for inhibitory chondroitin sulfate proteoglycans. PMID: 20179269
    12. Transient overexpression of the short splice variant 3 of RPTPR Sigma conferred alpha-LTX induced secretion to hamster insulinoma (HIT-15) cells. In contrast, the long splice variant 2 was inactive in secretion or in a single cell assay. PMID: 16552719
    13. Three SNPs that flank exon 8 are associated with ulcerative colitis. The presence of these SNPs is associated with novel splicing that removes the third immunoglobulin-like domain (exon 9) from the extracellular portion of PTPsigma. PMID: 17614280
    14. SNPs rs1143699, rs4807015, and rs1978237 confer an increased risk of developing type 2 diabetes mellitus. PMID: 17893260
    15. In colorectal tumors, microsatellite repeats mutation rates are higher than the mean mutation frequency PMID: 19000305

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Perikaryon. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic density. Cell projection, neuron projection. Cell projection, growth cone.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 2A subfamily
  • 組織特異性：
    Detected in peripheral blood plasmacytoid dendritic cells (at protein level). Detected in all tissues tested except for placenta and liver. Detected in peripheral blood plasmacytoid dendritic cells.
  • 數據庫鏈接：

    HGNC: 9681

    OMIM: 601576

    KEGG: hsa:5802

    STRING: 9606.ENSP00000349932

    UniGene: Hs.744928



主站蜘蛛池模板： 青青草无码免费一二三区| 国产一三四2021不卡| 无码人妻精品中文字幕| 玩弄少妇高潮ⅹxxxyw| 麻豆精品一卡二卡三卡| 乱无码伦视频在线观看| 国产精品喷浆| 国产午夜精品无码| 亚洲中文字幕在线无码一区二区| 少妇人妻综合久久中文| 无码精品a∨在线观看中文| 热re99久久精品国产66热| 久久久水蜜桃国产成人网站| 久久激情五月丁香伊人| 丰满少妇69激情啪啪无| 狠狠色婷婷久久综合频道日韩| 国产精品麻豆成人av网| 久久性色av亚洲电影| 国产成a人亚洲精品无码久久网| 成人看片黄a免费看在线| 精品999日本久久久影院| 亚洲人成网7777777国产| 国产一区二区三区成人欧美日韩在线观看 | 色悠久久久久综合网国产| 国产色婷婷五月精品综合在线| 浪荡女天天不停挨cao日常视频| 伊人精品成人久久综合97| 337p大胆啪啪私拍人体| 伊人情人色综合网站| 高清国产亚洲欧洲av综合一区| 免费观看又污又黄的网站| 小雪尝禁果又粗又大的视频| 日本中文字幕乱码aa高清电影| 国产黑色丝袜在线看片不卡顿| 日韩成人无码一区二区三区| 亚洲性人人天天夜夜摸| 蜜柚av久久久久久久| 精品午夜福利1000在线观看| 一边捏奶头一边啪高潮视频| 日本免费人成在线观看网站| 国产午夜成人久久无码一区二区|