在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PTPRK Antibody, FITC conjugated

  • 中文名稱:
    PTPRK兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA613588LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PTPRK Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PTPRK
  • 別名:
    dJ480J14.2.1 antibody; DKFZp686C2268 antibody; DKFZp779N1045 antibody; OTTHUMP00000017180 antibody; OTTHUMP00000017181 antibody; OTTHUMP00000017182 antibody; OTTHUMP00000017187 antibody; OTTHUMP00000040306 antibody; Protein tyrosine phosphatase kappa antibody; Protein tyrosine phosphatase kappa precursor antibody; Protein tyrosine phosphatase receptor type K antibody; Protein tyrosine phosphatase receptor type kappa antibody; Protein-tyrosine phosphatase kappa antibody; PTPK antibody; PTPkappa antibody; Ptprk antibody; PTPRK_HUMAN antibody; R PTP kappa antibody; R-PTP-kappa antibody; Receptor type tyrosine protein phosphatase kappa antibody; Receptor-type tyrosine-protein phosphatase kappa antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Receptor-type tyrosine-protein phosphatase kappa protein (589-749AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
  • 基因功能參考文獻:
    1. PTPRK was identified as a direct target of miR-1260b, and PTPRK expression was inversely correlated with miR-1260b in non-small cell lung cancer cell lines and clinical tissues PMID: 29628123
    2. Study found a significant association between PTPRK genetic variants and the risk and age at onset of Alzheimer's disease in two independent samples, and provided initial evidence of several genetic variants in PTPRK influencing the risk of cancer and cholesterol levels. PMID: 28987514
    3. The present study identified RSPO fusion transcripts, including three novel transcripts, in one-third of colorectal Traditional serrated adenoma (TSA) and showed that PTPRK-RSPO3 fusions were the predominant cause of RSPO overexpression in colorectal TSA. PMID: 28543708
    4. PTPRK plays dual roles in coordinating angiogenesis. It plays a positive role in cell proliferation, adhesion and tubule formation, but suppresses cell migration, in particular, the FGF-promoted migration. PMID: 28259897
    5. PTPRK-RSPO3 fusions and RNF43 mutations were found to be characteristic genetic features of traditional serrated adenomas (TSAs). PMID: 26924569
    6. By regulating phosphorylation of SRC, RPTPkappa promotes the pathogenic action of rheumatoid arthritis fibroblast-like synoviocytes, mediating cross-activation of growth factor and inflammatory cytokine signalling by TGFbeta in RA FLS. PMID: 25378349
    7. Notch and TGF-beta act in concert to stimulate induction of PTPRK, which suppresses EGFR activation in human keratinocytes. PMID: 25609089
    8. Findings strongly indicate that the tyrosine phosphorylation of CD133, which is dephosphorylated by PTPRK, regulates AKT signaling and has a critical role in colon cancer progression. PMID: 24882578
    9. PTPRK underexpression leads to STAT3 activation and contributes to nasal NK/T-cell lymphoma pathogenesis PMID: 25612622
    10. PTPRK showed lower mRNA expression in duodenal mucose of celiac disease patients. PMID: 23820479
    11. High expression of PTPRK is associated with prostate cancer. PMID: 24002526
    12. Tumor derived mutations of protein tyrosine phosphatase receptor type k affect its function and alter sensitivity to chemotherapeutics in glioma. PMID: 23696788
    13. PTPRK is a negative regulator of adhesion, invasion, migration, and proliferation of breast cancer cells. PMID: 23552869
    14. PTPkappa was scissored by the processed form of proprotein convertase 5, and galectin-3 binding protein which is over-produced in colon cancer cells and tissues. PMID: 21094132
    15. These data describe a novel mechanism of cross-talk between EGFR and TGF-beta pathways, in which RPTP-kappa functions to integrate growth-promoting and growth-inhibiting signaling pathways. PMID: 19864455
    16. Our results suggest that GnT-V could decrease human hepatoma SMMC-7721 cell adhesion and promote cell proliferation partially through RPTPkappa. PMID: 19911372
    17. RPTP-kappa is a key regulator of EGFR tyrosine phosphorylation and function in human keratinocytes PMID: 16263724
    18. the crystal structure of catalytically active, monomeric D1 domain of RPTPkappa at 1.9 A. RPTPkappa is monomeric in solution and crystal structure. PMID: 16672235
    19. EGF receptor is activated in human keratinocytes by oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irradiation PMID: 16849327
    20. EBNA1 apparently disables TGF-beta signaling, which subsequently decreases transcription of the PTPRK tumor suppressor PMID: 17720884
    21. PTPRK influences transactivating activity of beta-catenin in non-tumoral and neoplastic cells by regulating the balance between signaling and adhesive beta-catenin, thus providing biochemical basis for the hypothesis of PTPRK as a tumor suppressor gene. PMID: 18276111
    22. overexpression of GnT-V in a hepatoma cell line not only induced the addition of beta1,6 GlcNAc branch to N-glycan of RPTPkappa but also decreased the protein level of RPTPkappa PMID: 19236842
    23. These data indicate that PPTRK positively regulates ERK1/2 phosphorylation, which impacts CD4(+) T cell development. PMID: 19800317

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Receptor class 2B subfamily
  • 組織特異性:
    High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.
  • 數據庫鏈接:

    HGNC: 9674

    OMIM: 602545

    KEGG: hsa:5796

    STRING: 9606.ENSP00000357196

    UniGene: Hs.155919



主站蜘蛛池模板: 中美日韩毛片免费播放| 亚洲精品专区在线观看| 亚洲无av码在线中文字幕| 亚洲综合激情五月丁香六月| 色欲香天天天综合网站| 国产成人精品无码片区在线观看| 一本大道一卡2卡三卡4卡国产 | 中文资源在线天堂库8| 国产精品成人免费视频网站京东| 少女韩国电视剧在线观看完整| 亚洲影院天堂中文av色| 尤物蜜芽国产成人精品区| 无码熟妇人妻av在线电影| 欧美性生交大片18禁止| 午夜福利片手机在线播放| 久久亚洲精品成人av无码网站 | 日韩欧美国产一区精品| 欧洲精品欧美精品| 色狠狠成人综合网| 欧美国产亚洲日韩在线二区 | 丰满少妇69激情啪啪无| 偷拍区清纯另类丝袜美腿| 冲田杏梨av一区二区三区| 精品国产午夜福利在线观看| 天堂在线中文| 国产成人无码免费视频在线| 亚洲男人综合久久综合天堂| 日韩亚洲欧美中文高清在线| 精品乱码一区二区三四区视频| 国产白丝无码免费视频| 日本xxxx少妇高清hd| 国产亚洲精品自在久久| 国产乱码免费卡1卡二卡3| 日产精品中文一区二区三区 | 一本一道波多野结衣av一区| 国产白嫩漂亮美女在线观看 | 日本高清成本人视频一区| 春色校园综合人妻av| 99日本精品永久免费久久 | 亚洲欧美在线观看品| 成人网站在线进入爽爽爽|