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  4. PTPN18 Antibody

PTPN18 Antibody

  • 中文名稱：
    PTPN18兔多克隆抗體
  • 貨號：
    CSB-PA858731ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: PTPN18 antibody IgG at 2.98μg/ml + Rat heart tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 51, 39 kDa
      Observed band size: 51 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA858731ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PTPN18 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PTPN18
  • 別名：
    BDP 1 antibody; Brain derived phosphatase antibody; Brain-derived phosphatase antibody; Protein tyrosine phosphatase non receptor type 18 antibody; Protein tyrosine phosphatase non receptor type 18 brain derived antibody; PTN18_HUMAN antibody; PTP HSCF antibody; PTPN 18 antibody; PTPN18 antibody; Tyrosine protein phosphatase non receptor type 18 antibody; Tyrosine-protein phosphatase non-receptor type 18 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human Tyrosine-protein phosphatase non-receptor type 18 protein (1-210AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
  • 基因功能參考文獻：
    1. PTPN12, PTPRN and PTPN18 were independent prognostic factors in Hepatocellular Carcinoma. PMID: 29742497
    2. PTPN18 regulates HER2-mediated cellular functions through defining both its phosphorylation and ubiquitination barcodes. PMID: 25081058
    3. BDP1 has a role in negative regulation of HER2 signaling PMID: 14660651
    4. novel isoform of PTPN18 based on analysis of expressed sequence tags was discovered; deletion of 4 exons in the catalytic domain of the isoform may alter enzymatic activity; 2 of the novel isoform predictions were experimentally validated through RT-PCR PMID: 16303740
  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class 4 subfamily
  • 組織特異性：
    Expressed in brain, colon and several tumor-derived cell lines.
  • 數據庫鏈接：

    HGNC: 9649

    OMIM: 606587

    KEGG: hsa:26469

    STRING: 9606.ENSP00000175756

    UniGene: Hs.516390



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