在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PTPN12 Antibody, Biotin conjugated

  • 中文名稱:
    PTPN12兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA019026LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PTPN12 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PTPN12
  • 別名:
    Protein tyrosine phosphatase G1 antibody; Protein tyrosine phosphatase non receptor type 12 antibody; Protein-tyrosine phosphatase G1 antibody; PTN12_HUMAN antibody; PTP PEST antibody; PTP-PEST antibody; PTPG1 antibody; Ptpn12 antibody; Tyrosine protein phosphatase non receptor type 12 antibody; Tyrosine-protein phosphatase non-receptor type 12 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Tyrosine-protein phosphatase non-receptor type 12 protein (539-714AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'.
  • 基因功能參考文獻:
    1. identified a new phosphorylation-based substrate recognition mechanism of PTPN12 by CDK2, which orchestrated signaling crosstalk between the oncogenic CDK2 and HER2 pathways PMID: 28842430
    2. PTPN12 plasmid transfection increased PTPN12 mRNA and protein expressions, suppressed cell proliferation and migration, reduced EGFR level, and enhanced caspase 3 activity compared with control and empty plasmid groups. PMID: 29634414
    3. PTPN12, PTPRN and PTPN18 were independent prognostic factors in Hepatocellular Carcinoma. PMID: 29742497
    4. Here, solved is a crystal structure of the native PTPN12 catalytic domain with the catalytic cysteine (residue 231) in dual conformation (phosphorylated and unphosphorylated). PMID: 29278368
    5. this study, with a relative large population, showed that PTPN12 eQTL SNP may interact with HBV mutation on HCC risk. PMID: 27075395
    6. MyoVa-Ca(2+) channel interactions are required for proper long-range axon growth in developing spinal cord in vivo. PMID: 27134172
    7. PTP-PEST regulates EphA3 activation both by affecting cytoskeletal remodelling and through its direct action as a PTP controlling EphA3 phosphorylation. PMID: 26644181
    8. Study suggests that PTPN12 expression is a valuable prognostic biomarker for non-small cell lung cancer. PMID: 25868976
    9. PTPN12 expression decreases in human renal cell carcinoma PMID: 26537073
    10. The decrease expression of PTPN12 might be important in conferring a more aggressive behavior in NPC. Thus, PTPN12 expression may be used as a novel independent prognostic biomarker for patients with NPC. PMID: 25663493
    11. PTPN12 is potentially a methylation-silenced TSG for breast cancer that may play an important role in breast carcinogenesis and could potentially serve as an independent prognostic factor for invasive breast cancer patients. PMID: 23044628
    12. Decreased expression of PTPN12 correlates with tumor recurrence and poor survival of patients with hepatocellular carcinoma. PMID: 24475046
    13. these data suggest that PTP-PEST affects epithelial cell motility by controlling the distribution and phosphorylation of p120 and its availability to control Rho GTPase activity. PMID: 24284071
    14. The involvement of PTPN12 in the antioxidant response of breast cancer cells suggests that PTPN12 may represent a novel therapeutic target for this disease PMID: 23435421
    15. Overexpression of PTPN12 inhibited proliferation and migration in OSCC cells. PMID: 23733313
    16. MRNAs of PTPN12, MSH6, and ZEB1 orthologous genes from different animal species have binding sites for hsa-miR-1279 which consist of homologous oligonucleotides encoding similar human oligopeptides PMID: 23957009
    17. High expression of PTPN12 is associated with favorable disease free survival in esophageal squamous cell carcinoma patients. PMID: 22429674
    18. activated Ras induces extracellular signal-regulated kinase 1 and 2-dependent phosphorylation of PTP-PEST at S571, which recruits PIN1 to bind to PTP-PEST PMID: 21876001
    19. Using a genetic screen, study identifies the PTPN12 tyrosine phosphatase as a tumor suppressor in PMID: 21376233
    20. PTP-PEST functions as a suppressor of epithelial cell motility by controlling Rho GTPase activity and the assembly of adherens junctions. PMID: 20519451
    21. PTP-PEST actively contributes to the cellular apoptotic response and reveal the importance of caspases as regulators of PTPs in apoptosis. PMID: 17130234
    22. These data demonstrate that LPXN forms a signaling complex with Pyk2, c-Src, and PTP-PEST to regulate migration of prostate cancer cells. PMID: 17329398
    23. No association was detected between individual PTPN12 tag SNPs and GD but preliminary evidence suggests PTPN12 confers an increased risk of mild/moderate ophthalmopathy (NOSPECS classes 2-4) and that PTPN12 interacts with the TSHR. PMID: 17608818

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell junction, focal adhesion. Cell projection, podosome.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Non-receptor class 4 subfamily
  • 數據庫鏈接:

    HGNC: 9645

    OMIM: 600079

    KEGG: hsa:5782

    STRING: 9606.ENSP00000248594

    UniGene: Hs.61812



主站蜘蛛池模板: 国产偷窥熟女精品视频 | 人妻丰满被色诱中文字幕| 五十路亲子中出在线观看| 97人妻无码专区| 2021自拍偷在线精品自拍偷| 无码人妻丝袜视频在线播免费 | 亚洲最大av资源站无码av网址| 美女露出奶头扒开尿口免费网站 | 韩国午夜福利片在线| 国产精品午夜小视频观看| 亚洲第一aaaaa片| 国产精品沙发系列| 少妇爽到呻吟的视频| 乌克兰少妇xxxx做受野外| 亚洲狠狠婷婷综合久久蜜芽| 国产桃色无码视频在线观看| 岛国无码av不卡一区二区| 国产露脸150部国语对白| 亚洲爆乳无码一区二区三区| 亚洲精品久久yy5099| 免费床视频大全叫不停欧美| 99re6在线视频精品免费下载| 男女车车的车车网站w98免费| 97热久久免费频精品99| 特黄熟妇丰满人妻无码| 国产欧美另类久久精品蜜芽| 婷婷五月开心亚洲综合在线| 欧美在线精彩视频免费播放| 精品乱码一区内射人妻无码| 无码专区 丝袜美腿 制服师生| 潮喷失禁大喷水av无码| 真人抽搐一进一出视频| 日产亚洲一区二区三区| 西西艺术人像摄影| 文中字幕一区二区三区视频播放| 日日噜噜夜夜狠狠视频| 亚洲精品国产一区二区三| 欧美人与zoxxxx另类| 老熟妇高潮喷了╳╳╳| 国产精品无码a∨果冻传媒| 久久久国产精品人人片|