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  4. PTF1A Antibody

PTF1A Antibody

  • 中文名稱：
    PTF1A兔多克隆抗體
  • 貨號：
    CSB-PA018967LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Mouse brain tissue, Rat liver tissue
      All lanes: PTF1A antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 35 kDa
      Observed band size: 35 kDa
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA018967LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA018967LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PTF1A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PTF1A
  • 別名：
    bHLH transcription factor p48 antibody; bHLHa29 antibody; Class A basic helix-loop-helix protein 29 antibody; Class II bHLH protein PTF1A antibody; Exocrine pancreas specific transcription factor p48 antibody; p48 DNA binding subunit of transcription factor PTF1 antibody; p48 DNA-binding subunit of transcription factor PTF1 antibody; PACA antibody; PAGEN2 antibody; Pancreas specific transcription factor 1a antibody; Pancreas transcription factor 1 subunit alpha antibody; Pancreas-specific transcription factor 1a antibody; PTF 1A antibody; PTF1 p48 antibody; PTF1-p48 antibody; Ptf1a antibody; PTF1A_HUMAN antibody; PTF1P48 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Pancreas transcription factor 1 subunit alpha protein (224-325AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，PTF1A Antibody (CSB-PA018967LA01HU)，的標(biāo)記方式是Non-conjugated。對于PTF1A Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA018967LB01HU PTF1A Antibody, HRP conjugated ELISA
    FITC CSB-PA018967LC01HU PTF1A Antibody, FITC conjugated
    Biotin CSB-PA018967LD01HU PTF1A Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.
  • 基因功能參考文獻(xiàn)：
    1. non-neural progenitor transcription factor Ptf1a alone is sufficient to directly reprogram mouse and human fibroblasts into self-renewable induced neural stem cells capable of differentiating into functional neurons, astrocytes and oligodendrocytes, and improving cognitive dysfunction of Alzheimer's disease mouse models when transplanted PMID: 30030434
    2. Study describes the wide range of gene control by PTF1A that maintains the specific characteristics of pancreatic acinar cell identity and differentiation. PTF1A controls the pancreatic acinar transcription program by direct action at a thousand genes and in collaboration with other less cell type-restricted factors to ensure acinar cell homeostasis and to suppress other cell-type-specific programs. PMID: 27697859
    3. Data show isolated Pancreatic Aplasia Due to a Hypomorphic PTF1A Mutation PMID: 27284104
    4. The results of this study suggested Ptf1a-dependent cell-fate misspecification as a novel mechanism of human brainstem pathology. PMID: 26937009
    5. PTF1A enhancer mutations have been shown to cause neonatal diabetes associated with pancreatic agenesis PMID: 26184423
    6. Loss of Ptf1a alone is sufficient to induce acinar-to-ductal metaplasia, potentiate inflammation, and induce a KRAS-permissive, pancreatic ductal adenocarcinoma-like gene expression profile. PMID: 26151762
    7. The results of the present study do not support the hypothesis that high penetrant mutations in these regions of PTF1A are involved in the development of human VATER/VACTERL association or NTDs PMID: 25775927
    8. ata indicate that E3 ubiquitin ligase thyroid hormone receptor-interacting protein 12 (TRIP12) promotes proteasomal degradation of pancreas transcription factor 1a (PTF1a)and regulates PTF1a activities. PMID: 25355311
    9. Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis. PMID: 24212882
    10. ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression. PMID: 23339455
    11. ptf1a functions as a "pancreatic determiner". PMID: 20668890
    12. P48 interacts with the RBP-L and RBP-J subunits primarily through two short conserved tryptophan-containing motifs, similar to the motif of the Notch intracellular domain (NotchIC) that interacts with RBP-J. PMID: 16354684
    13. Controls the fate, survival, differentiation, and migration of climbing fiber neurons during their development in the transgenic murine inferior olivary nucleus. PMID: 17928434
    14. A critical and selective role of p/CAF in PTF1-dependent gene activation during acinar differentiation. PMID: 18834332
    15. Here we report a new case of cerebellar agenesis and neonatal diabetes mellitus whose parents are PTF1A mutation carriers. PMID: 19650412
    16. Two separable genomic regions code for initiation and positive feedback of Ptf1a transgene expression in the developing nervous system. PMID: 19741120

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  • 相關(guān)疾病：
    Pancreatic and cerebellar agenesis (PACA); Pancreatic agenesis 2 (PAGEN2)
  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm.
  • 組織特異性：
    Pancreas-specific (at protein level). Loss of expression is seen in ductal type pancreas cancers.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23734

    OMIM: 607194

    KEGG: hsa:256297

    STRING: 9606.ENSP00000365687

    UniGene: Hs.351503



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