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PSPH Antibody

  • 中文名稱:
    PSPH兔多克隆抗體
  • 貨號:
    CSB-PA018938GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    PSPH
  • 別名:
    EC 3.1.3.3 antibody; L 3 phosphoserine phosphatase antibody; L-3-phosphoserine phosphatase antibody; O phosphoserine phosphohydrolase antibody; O-phosphoserine phosphohydrolase antibody; Phosphoserine phosphatase antibody; Phosphoserine phosphatase deficiency; included antibody; PSP antibody; PSPase antibody; Psph antibody; PSPHD antibody; SERB_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PSPH
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine. L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator. May also act on O-phospho-D-serine (Probable).
  • 基因功能參考文獻:
    1. PSPH expression is a novel biomarker for poor prognosis and could play an important role in tumor progression of colorectal cancer. PMID: 28476802
    2. We further uncovered that phosphoserine phosphatase (PSPH), the final rate-limiting enzyme of the SSP pathway, is critical for cMyc-driven cancer progression both in vitro and in vivo PMID: 25793315
    3. study of an intellectual disability family from Pakistan; identified a variant in PSPH: chr7:56088803C>T, NM_004577.3 c.103G>A; p.Ala35Thr (hg19) which segregated in homozygous form with the phenotype in both branches of the family PMID: 25080166
    4. phosphoserine phosphatase deficiency is associated with Neu-Laxova syndrome. PMID: 25152457
    5. status of PSPH in normal skin epidermis and skin tumors along with its sub-cellular localization in epidermal keratinocytes and its requirement for squamous cell carcinoma proliferation PMID: 21726982
    6. purification, crystallization and preliminary X-ray diffraction analysis PMID: 11752790
    7. description of the first crystal structures of the HPSP in complexes with the competitive inhibitor 2-amino-3-phosphonopropionic a PMID: 12213811
    8. human phosphoserine phosphatase structure now shows a sevenfold coordinated Ca(2+) ion in the active site that might explain the inhibitory effect of Ca(2+) on the enzyme PMID: 15291819

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  • 相關(guān)疾病:
    Phosphoserine phosphatase deficiency (PSPHD)
  • 亞細胞定位:
    Cytoplasm, cytosol.
  • 蛋白家族:
    HAD-like hydrolase superfamily, SerB family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 9577

    OMIM: 172480

    KEGG: hsa:5723

    STRING: 9606.ENSP00000275605

    UniGene: Hs.512656



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