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  4. PSMD2 Antibody

PSMD2 Antibody

  • 中文名稱：
    PSMD2兔多克隆抗體
  • 貨號：
    CSB-PA619755LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, U251 whole cell lysate
      All lanes: PSMD2 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 101, 83, 86 kDa
      Observed band size: 101, 40 kDa
    • IHC image of CSB-PA619755LA01HU diluted at 1:1000 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA619755LA01HU at 1:333, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PSMD2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PSMD2
  • 別名：
    26S proteasome non-ATPase regulatory subunit 2 antibody; 26S proteasome regulatory subunit RPN1 antibody; 26S proteasome regulatory subunit S2 antibody; 26S proteasome subunit p97 antibody; 55.11 protein antibody; MGC14274 antibody; P97 antibody; Proteasome (prosome macropain) 26S subunit non ATPase 2 antibody; Proteasome 26S subunit; non-ATPase; 2 antibody; Proteasome 26S; subunit 2 antibody; Protein 55.11 antibody; Psmd2 antibody; PSMD2_HUMAN antibody; Rpn1 antibody; S2 antibody; TNFR associated protein 2 antibody; TRAP2 antibody; Tumor necrosis factor receptor associated protein 2 antibody; Tumor necrosis factor type 1 receptor-associated protein 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human 26S proteasome non-ATPase regulatory subunit 2 protein (401-700AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PSMD2 Antibody (CSB-PA619755LA01HU)，的標記方式是Non-conjugated。對于PSMD2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA619755LB01HU PSMD2 Antibody, HRP conjugated ELISA
    FITC CSB-PA619755LC01HU PSMD2 Antibody, FITC conjugated
    Biotin CSB-PA619755LD01HU PSMD2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:1000-1:2000
    IF 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.; Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
  • 基因功能參考文獻：
    1. the high-resolution solution structure of the UBL domain of human UBLCP1 and its interaction with Rpn1 PMID: 23667555
    2. Results suggest that PSMD2 may be a good molecular target candidate. PMID: 21465578
    3. These data suggest that p97 recruits proteasomes to polytopic ER proteins, such as Insig-1, even before they are extracted from membranes. PMID: 19815544
    4. U87 glioblastoma cells transduced to express the epidermal growth factor receptor vIII (EGFRvIII) mutant do not respond toirrradiation with 26s proteasome inhibition. PMID: 18337449
    5. Data show that data provide a novel mechanism whereby CaMKII may regulate the proteasome in neurons to facilitate remodeling of synaptic connections through protein degradation. PMID: 19638347
    6. the 26S proteasome may provide a general predictive biomarker for radiotherapy outcome. PMID: 19881955

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  • 蛋白家族：
    Proteasome subunit S2 family
  • 組織特異性：
    Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.
  • 數據庫鏈接：

    HGNC: 9559

    OMIM: 606223

    KEGG: hsa:5708

    STRING: 9606.ENSP00000310129

    UniGene: Hs.518464



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