在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PSMD14 Antibody, HRP conjugated

PSMD14 Antibody, HRP conjugated

  • 中文名稱：
    PSMD14兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA018904OB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PSMD14 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PSMD14
  • 別名：
    26S proteasome non-ATPase regulatory subunit 14 antibody; 26S proteasome regulatory subunit rpn11 antibody; 26S proteasome-associated PAD1 homolog 1 antibody; 26S proteasome-associated PAD1 homolog antibody; PAD1 antibody; PAD1, yeast, homolog of antibody; POH1 antibody; Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 antibody; Proteasome 26S subunit non ATPase 14 antibody; PSDE_HUMAN antibody; Psmd14 antibody; RPN11 antibody; Testis tissue sperm binding protein Li 69n antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Peptide sequence from Human 26S proteasome non-ATPase regulatory subunit 14 protein (264-283AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
  • 基因功能參考文獻(xiàn)：
    1. overexpression of RPN11 in breast cancer tissues was associated with an advanced clinical stage. Patients with tumors with high expression of RPN11 had worse prognosis. PMID: 28535005
    2. Deubiquitylase POH1 stabilizes E2F1 protein through binding to and deubiquitylating E2F1 in liver cancer. PMID: 26510456
    3. The data demonstrated that proteasomal POH1 is a key de-ubiquitinating enzyme that regulates ubiquitin conjugates generated in response to damage and that several aspects of the DNA double-strand break response are regulated by the proteasome. PMID: 22909820
    4. Disorder of POH1 expression is involved in the onset of idiopathic nephrotic syndrome (INS), and confers multidrug resistance in children with INS PMID: 19419512
    5. Down-regulation of PSMD14 results in decreased cell proliferation, cell cycle arrest and senescence. A comparative study with PSMB5, revealed that PSMB5 and PSMD14 have different effects on cell cycle, senescence and associated molecular events. PMID: 19732767
    6. Ectopic expression of POH1 in HEK293 cells decreased the level of c-Jun ubiquitination, leading to significant accumulation of the protein and a corresponding increase in AP1-mediated gene expression PMID: 16569633
    7. An intact zinc metalloproteinase motif of Poh1 is essential for cell viability and 26S proteasome function. PMID: 17237285
    8. Specificity for K63-linked polyubiquitin is a common property of the JAMM/MPN+ family of deubiquitinating enzymes. PMID: 19214193

    顯示更多

    收起更多

  • 蛋白家族：
    Peptidase M67A family, PSMD14 subfamily
  • 組織特異性：
    Widely expressed. Highest levels in heart and skeletal muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16889

    OMIM: 607173

    KEGG: hsa:10213

    STRING: 9606.ENSP00000386541

    UniGene: Hs.740477



主站蜘蛛池模板： 亚洲一区二区三区在线播放无码| 天堂а√在线中文在线最新版| 色爽黄1000部免费软件下载| 亚洲伊人色欲综合网| 国产欧美日韩一区2区| 亚洲中文字幕无码天然素人| 亚洲欧洲日本综合aⅴ在线 | 国产做爰xxxⅹ久久久精华液| 熟女人妻大叫粗大受不了| 亚洲乱码中文字幕久久孕妇黑人| 在线播放国产不卡免费视频| 噜噜色综合天天综合网mp3| 成人精品天堂一区二区三区| 亚洲综合av永久无码精品一区二区| 欧美老妇牲交videos| 欧美人成视频在线视频| 欧美高清大屁股xxxxx| 无码少妇一区二区性色av| 野外做受又硬又粗又大视频| 在线观看片免费人成视频播放| 国产精品久久久久久日本| 欧美 日韩版国产在线播放| 久久综合给合综合久久| 国产日韩精品欧美一区喷水| 中文无码伦av中文字幕在线| 亚洲国产成人精品无码区一本| 亚洲熟妇无码爱v在线观看| 99精品久久久久久久婷婷| 欧洲日本一线二线三线区本庄铃| 高清国产在线拍揄自揄视频| 国产精品一区二区熟女不卡| 老熟女毛茸茸浓毛| 秋霞电影网午夜鲁丝片无码| 深夜国产成人福利在线观看| 亚洲国产av一区二区三区四区| 大伊香蕉精品视频在线天堂| 日韩精品无码久久久久久| 18禁美女裸体无遮挡免费观看国产| 亚洲中文字幕无码久久2017 | 久久天天躁狠狠躁夜夜2o2o| 自拍偷自拍亚洲精品被多人伦好爽 |