在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PSMB4 Antibody

  • 中文名稱:
    PSMB4兔多克隆抗體
  • 貨號:
    CSB-PA018882GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    PSMB4
  • 別名:
    26 kDa prosomal protein antibody; HN3 antibody; HsBPROS26 antibody; HSN3 antibody; Macropain beta chain antibody; Multicatalytic endopeptidase complex beta chain antibody; PROS-26 antibody; PROS26 antibody; Proteasome (prosome macropain) subunit beta type 4 antibody; Proteasome beta 4 subunit antibody; Proteasome beta chain antibody; Proteasome chain 3 antibody; Proteasome subunit beta 4 antibody; Proteasome subunit beta type 4 antibody; Proteasome subunit beta type-4 antibody; Proteasome subunit HsN3 antibody; PSB4_HUMAN antibody; PSMB 4 antibody; PSMB4 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PSMB4
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
  • 基因功能參考文獻(xiàn):
    1. High PSMB4 expression is associated with breast cancer. PMID: 30066880
    2. PSMB4 knockdown decreased the expression levels of MMP2, MMP9 and cathepsin B and decreased proliferation, migration and invasion abilities in human GBM cells. PMID: 29414809
    3. We further identified miR-148b as a negative regulator of proteasome beta-4 subunit. Enforced expression of miR-148b resulted in vitro growth inhibition of melanoma cells, whereas this inhibition was further abolished by enforced expression of proteasome beta-4 subunit PMID: 28656878
    4. Our findings implied that PSMB4 is involved in the progression of EOC (epithelial ovarian cancer) and could serve as potential therapeutical target of EOC. These data suggested that PSMB4 may promote cell proliferation via the NF-kappaB-target gene in EOC (epithelial ovarian cancer) PMID: 26439929
    5. Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-kappaB-miR-21 signaling, which may represent promising targets for novel specific therapies. PMID: 25656574
    6. Data indicate that recruitment of proteasomes into mutant huntingtin (mHTT) protein initiated inclusion bodies (IBs) was observed when the PSMB4-GFP was co-expressed with mHTT. PMID: 24291262
    7. proteasome subunit beta type 4 (PSMB4), the beta7 subunit of the 20S core complex, was identified as a direct binding partner of CRBN. PMID: 23026050
    8. While 26 proteasome dysfunction is observed in Parkinson's disease (PD), diverse mutations in the parkin gene are linked to early-onset autosomal-recessive forms of familial PD. PMID: 20810900

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Peptidase T1B family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 9541

    OMIM: 602177

    KEGG: hsa:5692

    STRING: 9606.ENSP00000290541

    UniGene: Hs.89545



主站蜘蛛池模板: 亚洲乱码中文字幕在线| 欧美真人性做爰全过程| 最近中文字幕在线中文视频| 内射人妻视频国内| 亚洲欧洲成人a∨在线观看| 狠日狠干日日射| 国产成人无码一区二区在线观看 | 娇小萝被两个黑人用半米长| av中文无码乱人伦在线观看| 99久久久国产精品消防器材| 亚洲成av人片在线观看无码| 国产精品96久久久久久| 极品无码av国模在线观看| 国产美女遭强高潮网站下载| 亚洲日韩国产av无码无码精品| 欧洲美女与动zooz| av影音先锋最大资源网| 亚洲伊人久久大香线蕉av| 人妻无码视频一区二区三区| 久久精品国产99久久丝袜蜜桃| 欧洲无线码免费一区| 国产精品亚洲色婷婷99久久精品| 99国产精品自在自在久久| 国产福利男女xx00视频| 国产亚洲精aa在线观看| 亚洲电影在线观看| 久久久噜噜噜久噜久久| 欧美特黄特色三级视频在线观看| 亚洲老妈激情一区二区三区| 国产无遮挡又黄又爽又色| 成人免费午夜无码视频在线播放 | 国产精品无码久久久久久 | 97热久久免费频精品99| 扒开双腿疯狂进出爽爽爽视频| 欧美大屁股xxxx高跟欧美黑人| 9久9久女女热精品视频在线观看| 国产av一区二区精品久久凹凸 | 天干夜天干天天天爽视频 | 99精品国产兔费观看久久| 亚洲欧洲精品无码av| 人人妻人人澡人人爽秒播|