在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PSMB4 Antibody

  • 中文名稱:
    PSMB4兔多克隆抗體
  • 貨號:
    CSB-PA018882GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    PSMB4
  • 別名:
    26 kDa prosomal protein antibody; HN3 antibody; HsBPROS26 antibody; HSN3 antibody; Macropain beta chain antibody; Multicatalytic endopeptidase complex beta chain antibody; PROS-26 antibody; PROS26 antibody; Proteasome (prosome macropain) subunit beta type 4 antibody; Proteasome beta 4 subunit antibody; Proteasome beta chain antibody; Proteasome chain 3 antibody; Proteasome subunit beta 4 antibody; Proteasome subunit beta type 4 antibody; Proteasome subunit beta type-4 antibody; Proteasome subunit HsN3 antibody; PSB4_HUMAN antibody; PSMB 4 antibody; PSMB4 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PSMB4
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
  • 基因功能參考文獻(xiàn):
    1. High PSMB4 expression is associated with breast cancer. PMID: 30066880
    2. PSMB4 knockdown decreased the expression levels of MMP2, MMP9 and cathepsin B and decreased proliferation, migration and invasion abilities in human GBM cells. PMID: 29414809
    3. We further identified miR-148b as a negative regulator of proteasome beta-4 subunit. Enforced expression of miR-148b resulted in vitro growth inhibition of melanoma cells, whereas this inhibition was further abolished by enforced expression of proteasome beta-4 subunit PMID: 28656878
    4. Our findings implied that PSMB4 is involved in the progression of EOC (epithelial ovarian cancer) and could serve as potential therapeutical target of EOC. These data suggested that PSMB4 may promote cell proliferation via the NF-kappaB-target gene in EOC (epithelial ovarian cancer) PMID: 26439929
    5. Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-kappaB-miR-21 signaling, which may represent promising targets for novel specific therapies. PMID: 25656574
    6. Data indicate that recruitment of proteasomes into mutant huntingtin (mHTT) protein initiated inclusion bodies (IBs) was observed when the PSMB4-GFP was co-expressed with mHTT. PMID: 24291262
    7. proteasome subunit beta type 4 (PSMB4), the beta7 subunit of the 20S core complex, was identified as a direct binding partner of CRBN. PMID: 23026050
    8. While 26 proteasome dysfunction is observed in Parkinson's disease (PD), diverse mutations in the parkin gene are linked to early-onset autosomal-recessive forms of familial PD. PMID: 20810900

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Peptidase T1B family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 9541

    OMIM: 602177

    KEGG: hsa:5692

    STRING: 9606.ENSP00000290541

    UniGene: Hs.89545



主站蜘蛛池模板: 天堂一区人妻无码| 午夜天堂一区人妻| 国产精品免费精品自在线观看| 国产猛男猛女超爽免费视频| 满春阁精品a∨在线观看| 在线播放免费播放av片| 波多野结衣超清无码专区| 亚洲人成色77777在线观看| 国产一区二区三区久久精品| а√天堂资源中文在线官网| 日本精品中文字幕在线播放| 777米奇色狠狠俺去啦| 男女性高爱潮免费网站| 少妇高潮喷潮久久久影院| 亚洲熟妇av午夜无码不卡| 国产精品人妻在线观看| 国产乱沈阳女人高潮乱叫老 | 亚洲字幕av一区二区三区四区| 亚洲一卡2卡三卡四卡精品| 秋霞午夜鲁丝片午夜精品| 中文字幕 亚洲精品 第1页| 伊伊人成亚洲综合人网7777| 日本高清视频网站www| 国产免费午夜福利不卡片在线| 噜噜高清欧美内射短视频| 77777_亚洲午夜久久多人| 麻豆av一区二区三区久久| 五月丁香综合缴情六月小说| 老男人久久青草av高清| 国产大片黄在线观看| 中文字幕乱码亚洲精品一区 | 无码免费一区二区三区| 又粗又大又硬毛片免费看| 国产在热线精品视频99公交| 欧美阿v高清资源在线| 伴郎粗大的内捧猛烈进出视频观看 | 丰满岳妇乱一区二区三区| www国产亚洲精品| 成年日韩片av在线网站| 久久www成人片免费看| 亚洲成熟丰满熟妇高潮xxxxx|