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PSD Antibody

  • 中文名稱:
    PSD兔多克隆抗體
  • 貨號:
    CSB-PA018842LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate
      All lanes: PSD antibody at 3.2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 110, 71 kDa
      Observed band size: 110 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA018842LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA018842LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PSD Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    PSD antibody; EFA6 antibody; EFA6A antibody; KIAA2011 antibody; PSD1 antibody; TYL antibody; PH and SEC7 domain-containing protein 1 antibody; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 antibody; Exchange factor for ARF6 antibody; Exchange factor for ARF6 A antibody; Pleckstrin homology and SEC7 domain-containing protein 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human PH and SEC7 domain-containing protein 1 protein (247-489AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,PSD Antibody (CSB-PA018842LA01HU),的標記方式是Non-conjugated。對于PSD Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA018842LB01HU PSD Antibody, HRP conjugated ELISA
    FITC CSB-PA018842LC01HU PSD Antibody, FITC conjugated
    Biotin CSB-PA018842LD01HU PSD Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling.
  • 基因功能參考文獻:
    1. Arf GTPases are likely to be locally activated by EFA6 and in turn targeted to the Flemming body to complete cytokinesis. PMID: 26330566
    2. PSD expression might be a useful biomarker for epigenetic-based gastric cancer early diagnosis and may lead to the identification of new targets for pharmacological intervention. PMID: 25355626
    3. EFA6 is regulated by a negative feedback loop, which is mediated by an allosteric interaction of Arf6-GTP with a domain of EFA6 and monitors the activation of Arf1 and Arf6 differentially PMID: 25114232
    4. EFA6 participates in activation of Arf6 around the cleavage furrow during cytokinesis. PMID: 23603394
    5. Aberrant methylation of PSD occurs in UC-associated colorectal mucosa, enabling circumvention of Rac1 immune responses governing neutrophil chemotaxis and apoptosis, and plays a pivotal role in the mechanisms underlying UC-associated carcinogenesis. PMID: 22179719
    6. Both levels of accumulation of F-actin and apoptosis were significantly decreased in specimens from UC patients with PSD methylation compared to those without PSD methylation. PMID: 22002136
    7. Pleckstrin is a critical molecule for proinflammatory cytokine secretion in response to elevated advanced glycation end products (AGE) in diabetes. PMID: 17579087

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  • 亞細胞定位:
    Cell membrane. Cell projection, ruffle membrane. Cleavage furrow.
  • 蛋白家族:
    PSD family
  • 組織特異性:
    Isoform 2 is expressed in the brain.
  • 數據庫鏈接:

    HGNC: 9507

    OMIM: 602327

    KEGG: hsa:5662

    STRING: 9606.ENSP00000020673

    UniGene: Hs.154658



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