在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PROX1 Antibody

  • 中文名稱:
    PROX1兔多克隆抗體
  • 貨號:
    CSB-PA215840
  • 規格:
    ¥1100
  • 圖片:
    • Western Blot
      Positive WB detected in: 293 whole cell lysate, A549 whole cell lysate, 293T whole cell lysate,Mouse Liver tissue lysate
      All lanes: PROX1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 83 kDa
      Observed band size: 83 kDa
    • Immunofluorescence staining of Hela cell with CSB-PA215840 at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Homeobox prospero like protein antibody; Homeobox prospero like protein PROX1 antibody; Homeobox prospero-like protein PROX1 antibody; Prospero homeobox 1 antibody; Prospero homeobox protein 1 antibody; Prospero related homeobox 1 antibody; prospero-related homeobox gene 1 antibody; PROX 1 antibody; PROX-1 antibody; PROX1 antibody; PROX1_HUMAN antibody; zgc:111888 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Synthetic peptide of Human PROX1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IF 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
  • 基因功能參考文獻:
    1. PROX1 expression was detected in gastric cancer tissues at various levels. PROX1 expression levels were positively correlated with cancer stage, N factor, lymphatic vascular invasion, and vascular invasion in patients with gastric cancer. PMID: 30396930
    2. The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 contribute to lymph endothelial cells retraction. PMID: 29749465
    3. Prox1 is a critical transcription factor for the differentiation of myoblasts via bi-directional crosstalk with Notch1. PMID: 27731315
    4. PROX1 is a new prognostic biomarker for 1p19q non-codeleted high-grade astrocytomas that have progressed from pre-existing low-grade tumors and harbor IDH mutations. PMID: 27626492
    5. ERbeta in both normal and cancerous colon epithelial cells upregulates miRNA-205, which subsequently reduces PROX1 through direct interaction with its 3'UTR PMID: 27283988
    6. The aim of this study was to examine the association between HHEX (rs5015480) and PROX1 (rs340874) gene polymorphisms and Gestational diabetes mellitus (GDM) .Despite these associations, PROX1 gene variants were not previously examined in women with GDM; however, our results suggest a lack of such an association. PMID: 27684496
    7. PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response. PMID: 27476001
    8. crucial promoter of hepatocellular carcinoma angiogenesis PMID: 28646551
    9. study achieved a long-lasting expression of Prox1 in lymphatic endothelial-like cells, and it provided a potentially useful approach for developing novel therapies for limb lymphedema and lymphatic system-related diseases PMID: 28055225
    10. In gastric cancer, high cytoplasmic PROX1 expression is an independent marker of better prognosis. PMID: 28854215
    11. High PROX1 and beta-catenin expression were independent factors for better prognosis in pancreatic ductal adenocarcinoma. PMID: 27411302
    12. Data suggest that DBC1 has a dual function in regulating beta-catenin-PROX1 signaling axis: as a coactivator for both beta-catenin and PROX1. PMID: 26477307
    13. PROX1 gene is a strong candidate of early onset of diabetes with variations depending on ethnicity. PMID: 28060188
    14. We also discovered and replicated three genome-wide significant variants in previously unreported loci for RDW (SLC12A2 rs17764730, PSMB5 rs941718), and hematocrit (PROX1 rs3754140) and an upstream anti-sense long-noncoding RNA, LINC01184, as the likely causal variant PMID: 28453575
    15. PROX1 serves an oncogenic role in glioblastoma multiforme and promotes cell proliferation and invasiveness potentially via activation of the NFkappa B signaling pathway. PMID: 28035380
    16. High PROX1 expression is associated with gastric cancer. PMID: 26759228
    17. High PROX1 expression is associated with Esophageal Squamous Cell Carcinoma. PMID: 26310281
    18. Reduced expression of Prox1 is beneficial for the expansion and maturation of beta-cells. PMID: 26631740
    19. PROX1 is an important regulator of endocrine secretory granule formation in medullary thyroid cancer cells. PMID: 26760117
    20. Findings demonstrate that NOTCH-induced PROX1 inactivation significantly promotes the malignant behavior of thyroid carcinoma. PMID: 26609053
    21. These results suggest that the hepatic functions of the human iPS-HLCs could be enhanced by ATF5, c/EBPalpha, and PROX1 transduction. PMID: 26679606
    22. In primary lymphatic endothelial cells (HDLEC), miR-466 mimic transfection suppressed Prox1 mRNA and protein expression. HDLEC transfected with the miR-466 mimic suppressed tube formation as compared to the scrambled control. PMID: 25573115
    23. Increase in PROX1 expression renders HCC cells more resistant to sorafenib treatment. PMID: 25684142
    24. Our results indicate that immunohistochemical detection of PROX1 correlates with a more malignant phenotype in rectal neuroendocrine tumors PMID: 26063416
    25. PROX1 target genes and show that repression of a pro-apoptotic member of the BCL2 family, BCL2L15, is important for survival of PROX1(+) cells under metabolic stress. PMID: 25242332
    26. Prox1 regulates PDPN expression at the transcriptional level in the lymphatic vascular system PMID: 24944097
    27. retina. These results confirm the conservative functions of Prox1/PROX1 in the vertebrate retina PMID: 25735162
    28. PROX1 functions as a tumor suppressor gene in oral carcinogenesis. PMID: 25526434
    29. These data suggest that PROX1 SNP rs340874 may be a pharmacogenetic risk factor for antihypertensive-induced hyperglycemia PMID: 24122840
    30. expression of Prox-1 in the neoplastic spindle cells supports the view of a lymphatic differentiation in oral Kaposi's sarcoma and it may also be involved in the pathogenesis of oral Kaposi's sarcoma. PMID: 23763431
    31. Our powerful strategic analysis enabled the discovery of a novel candidate gene, PROX1, associated with Waist circumference in an Asian population. PMID: 23818313
    32. Results suggested that Prox1 and FOXC2 play key roles in OSCC progression and that further studies focusing on these proteins may yield useful insights for diagnosis and therapy of OSCC. PMID: 24647631
    33. PDGFRB is one of the key mediators of lymphatic vessel formation acting downstream of Prox1. PMID: 24981766
    34. PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating hypoxia-inducible factor 1alpha expression and protein stability. PMID: 23505027
    35. Prox1 interacts with LSD1 to recruit the repressive LSD1/NuRD complex to CYP7A1 promoter and co-represses transcription through epigenetic mechanisms. PMID: 23626788
    36. Single Nucleotide Polymorphism in PROX1 gene is associated with type 2 diabetes. PMID: 22992776
    37. COUP-TFII orchestrates venous and lymphatic endothelial identity by homo- or hetero-dimerisation with PROX1 PMID: 23345397
    38. The present study aimed to find whether PROX1 is expressed in small cell lung cancer (SCLC) cell lines, and whether PROX1 knockdown with shRNA via lentivirus resulted in decreased cell proliferation. PMID: 23898075
    39. The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53-dependent senescence-like phenotype. PMID: 23291986
    40. Prox1 strongly suppresses the proliferation of mouse and human neuroblastoma cell lines and blocks the growth of neuroblastoma tumors in SCID mice. PMID: 22508481
    41. genetic association studies in adolescent populations in Europe: Data suggest that 3 SNPs in PROX1 (rs340838; rs340837; rs340836) are associated with fasting plasma insulin levels and may play a role in regulation of insulin secretion. PMID: 23274905
    42. PROX1 promotes epithelial-mesenchymal transition and colon cancer progression. PMID: 23045246
    43. Prox1 gene transcription is regulated by HIF-1alpha and HIF-2alpha in hypoxia. PMID: 23395615
    44. The presence of Prox1 nuclear expression was detected starting from CIN2 and CIN3 lesions to microinvasive carcinoma, in the nuclei of lymphatic and venous endothelial cells and scattered stromal cells. PMID: 23059885
    45. PROX1 directly binds to proximal promoter of TWIST1 gene to repress its transcription PMID: 22982861
    46. The only nominal association with diabetes incidence was found for the glucose-lowering allele at PROX1 (P = 0.02), in a direction opposite to that reported in case-control analyses in MAGIC. PMID: 22984506
    47. we report that IL3 receptor alpha (IL3Ralpha) and NOTCH play integral roles in the host cell type-specific regulation of PROX1 by Kaposi sarcoma herpes virus PMID: 22719258
    48. High PROX1 expression is associated with neuroblastomas. PMID: 22382784
    49. Prox1 is a direct upstream modifier of Nkx2.5 by maintaining the adult conduction system and rescue of Nkx2.5 conduction disease phenotypes. PMID: 22647876
    50. Prox1 expression in hemangiomas and angiosarcoma may be diagnostically useful and offer a new parameter in the biological classification of vascular tumors. PMID: 22067331

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Prospero homeodomain family
  • 組織特異性:
    Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
  • 數據庫鏈接:

    HGNC: 9459

    OMIM: 601546

    KEGG: hsa:5629

    STRING: 9606.ENSP00000261454

    UniGene: Hs.741808



主站蜘蛛池模板: 中文字幕无码精品亚洲资源网| 国产免费丝袜调教视频| 妖精色av无码国产在线看| 精品久久久久久亚洲中文字幕| 九九视频免费精品视频| 一本色道无码不卡在线观看 | 午夜福利在线永久视频| 国模无码一区二区三区不卡| 亚洲中国精品精华液| 久久综合给合久久狠狠狠97色| 亚洲欧美综合区丁香五月小说| 久热在线这里只有精品国产| 成人无遮挡裸免费视频在线观看| 国产丰满老熟妇乱xxx1区| 熟女精品视频一区二区三区| 天天看片天天av免费观看| 国产99在线 | 中国| 免费吃奶摸下激烈视频| 精品视频一区二区三区在线观看| 一本到中文无码av在线精品| 亚洲熟妇无码av不卡在线播放| 国产女主播喷水视频在线观看| 人人爽人人模人人人爽人人爱| 五月色婷婷丁香无码三级 | 俄罗斯大荫蒂女人毛茸茸| 男人和女人高潮做爰视频| 欧美大片aaaaa免费观看| 欧美freesex黑人又粗又大| 18处破外女出血在线| 丰满人妻无码∧v区视频| 欧美性猛交aaaa片黑人| 中文字幕日本最新乱码视频| 亚洲精品久久av无码一区二区 | 亚洲国产婷婷香蕉久久久久久| 国产八十老太另类| 中国china露脸自拍性hd| 国产精品久久久久永久免费看| 忘忧草日本在线播放www| 国产福利免费视频不卡| 日本三级欧美三级人妇视频黑白配| 美乳丰满人妻无码视频|