在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PROKR1 Antibody

PROKR1 Antibody

  • 中文名稱：
    PROKR1兔多克隆抗體
  • 貨號：
    CSB-PA003812
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of COLO205 cells using PKR1 Polyclonal Antibody
    • Western Blot analysis of Jurkat cells using PKR1 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    PROKR1; GPR73; PKR1; Prokineticin receptor 1; PK-R1; G-protein coupled receptor 73; G-protein coupled receptor ZAQ; GPR73a
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human PKR1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

產品評價

靶點詳情

  • 功能：
    Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.
  • 基因功能參考文獻：
    1. a significant association between PKR2 rs6053283 polymorphism and Recurrent pregnancy loss (RPL)(P=0.003), whereas no association was observed between PKR1 rs4627609 polymorphism and RPL (P=0.929) in the Chinese Han population. PMID: 26984842
    2. Data suggest that prokineticins (PROK1 and PROK2) and prokineticin receptors (PROKR1 and PROKR2) act as main regulators of physiological functions of ovary, uterus, placenta, and testis. [REVIEW] PMID: 26574895
    3. EG-VEGF and its receptor PKR1 might play a role in the pathogenesis of adrenocortical tumors and could serve as prognostic markers for this rare malignant disease. PMID: 26475302
    4. Expression of PROK1 and PROKR1 was significantly higher in mid-gestation ovaries (17-20 wk) than at earlier gestations (8-11 and 14-16 wk). PMID: 26192875
    5. Study corroborates the clinical relevance of the EG-VEGF system in human early pregnancy, and provides evidence for the gene-gene interactions of EG-VEGF and PROKR variants. PMID: 25064403
    6. I397V variant confers lower risk for recurrent miscarriage PMID: 23687280
    7. hCG increases EG-VEGF, PROKR1 and PROKR2 mRNA and protein expression in a dose- and time-dependent manner, demonstrating a new role for hCG in the regulation of EG-VEGF and its receptors PMID: 22138749
    8. The results suggest an identical transmembrane-bundle binding site for hPKR1 and hPKR2. PMID: 22132188
    9. Findings, together with the detection of sequence variants in PROKR1, PROK1 and PROKR2 genes associated to HSCR and, in some cases in combination with RET or GDNF mutations, provide evidence to consider them as susceptibility genes for HSCR. PMID: 21858136
    10. The number of PKR1 is not reduced in preeclampsia. PMID: 21876489
    11. Data suggest that smoking targets human Fallopian tubes via nAChRalpha-7 to increase tubal PROKR1, leading to alterations in the tubal microenvironment that could predispose to ectopic pregnancy. PMID: 20864676
    12. Data show that expression of PK1 and PKR1 was detected in primary MM cells and myeloma cell lines. PMID: 20795791
    13. Two tag SNPs of PKR1 (rs4627609, rs6731838) were significantly associated with idiopathic recurrent pregnancy loss. PMID: 20847187
    14. Data shown that PROK1-PROKR1 induces the expression of IL-11 in PROKR1 Ishikawa cells and first trimester decidua. PMID: 19801577
    15. The functional characteristics of coronary endothelial cells depend on the expression of PKR1 and PKR2 levels and the divergent signaling pathways used by these receptors. PMID: 20023120
    16. molecular cloning, amino acid sequence and expression in several human tissues PMID: 12427552
    17. Paracrine role for the PKs and their receptors in endometrial vascular function. PMID: 15126578
    18. study demonstrated that prokineticin 1 and 2 and their receptors are expressed in human prostate and that their levels increased with prostate malignancy PMID: 16763065
    19. PROK1 and PROKR1 expression is elevated in human decidua during early pregnancy PROK1-PROKR1 interaction regulates expression of a host of implantation-related genes. PMID: 18339712

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Localizes to glandular epithelium, stroma and vascular endothelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the stomach, throughout the small int
  • 數據庫鏈接：

    HGNC: 4524

    OMIM: 607122

    KEGG: hsa:10887

    STRING: 9606.ENSP00000303775

    UniGene: Hs.683430



主站蜘蛛池模板： 亚洲蜜桃v妇女| 永久免费的无码中文字幕| 99久久人人爽亚洲精品美女| 国产成人92精品午夜福利| 国产精品成人免费一区久久羞羞| 先锋影音男人av资源| 无码av在线一本无码| 精品第一国产综合精品蜜芽| 国产v亚洲v天堂a无码99| 日本高清一区二区三| 亚洲欧美中文日韩在线v日本| 永久免费的av片在线电影网| 久久99精品国产99久久6| 国产精品免费久久久久影院仙踪林| 影音先锋人妻啪啪av资源网站| 中年人妻丰满av无码久久不卡| 蜜臀av色欲a片无码一区| 日本黄页网站免费大全| 中文字幕无码视频专区| 欧美一区内射最近更新| 国产精品亚洲五月天高清| 亚洲精品一区二区国产精华液| 亚洲成a人片在线观看天堂无码| 日本高清在线一区二区三区| 亚洲欧美日韩综合久久| av无码中出一区二区三区| 男人j进入女人j内部免费网站| а√中文在线资源库| 女高中生第一次破苞av| 在线а√天堂中文官网| 丰满五十六十老熟女hd| 日韩av无码成人无码免费| 国产高清一区二区三区直播| 国产精品久久久久久亚洲色| 日日噜噜噜夜夜爽爽狠狠| 无码少妇一区二区三区芒果| 人妻无码少妇一区二区| 无码一区二区三区视频| 久久久精品人妻一区二区三区| 捆绑白丝粉色jk震动捧喷白浆| 香蕉视频在线精品视频|