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  4. PRMT7 Antibody
  • 中文名稱：
    PRMT7兔多克隆抗體
  • 貨號(hào)：
    CSB-PA885738LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Mouse spleen tissue, Mouse lung tissue, Mouse kidney tissue, Mouse brain tissue
      All lanes: PRMT7 antibody at 6.2μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 79, 63, 74, 64 kDa
      Observed band size: 79 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA885738LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA885738LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PRMT7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    [Myelin basic protein]-arginine N-methyltransferase PRMT7 antibody; ANM7_HUMAN antibody; FLJ10640 antibody; Histone-arginine N-methyltransferase PRMT7 antibody; KIAA1933 antibody; Myelin basic protein arginine N methyltransferase antibody; OTTHUMP00000174863 antibody; PRMT7 antibody; Protein arginine methyltransferase 7 antibody; Protein arginine N-methyltransferase 7 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Protein arginine N-methyltransferase 7 protein (285-390AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，PRMT7 Antibody (CSB-PA885738LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于PRMT7 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA885738LB01HU PRMT7 Antibody, HRP conjugated ELISA
    FITC CSB-PA885738LC01HU PRMT7 Antibody, FITC conjugated
    Biotin CSB-PA885738LD01HU PRMT7 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
  • 基因功能參考文獻(xiàn)：
    1. These kinetic studies suggest a biochemical explanation for the interplay between PRMT5- and PRMT7-mediated methylation of the same substrate at different residues and also suggest a general model for regulation of PRMTs. PMID: 28874563
    2. The authors showed that ASS1 mutations linked to type I citrullinemia disrupt the ASS1-PRMT7 interaction, which might explain the molecular pathogenesis of the disease. PMID: 28587924
    3. Loss of PRMT7 causes decreases in arginine methylation throughout the proteome.Loss of the arginine methyltranserase PRMT7 causes syndromic intellectual disability with microcephaly and brachydactyly. PMID: 27718516
    4. Upregulation of PRMT7 in breast cancer may have a significant role in promoting cell invasion through the regulation of MMP9. PMID: 25605249
    5. results define PRMT7 as an inducer of breast cancer metastasis and present the opportunity for applying PRMT7-targeted therapeutics to treat highly invasive breast cancers PMID: 25136067
    6. Data indicate that two acidic residues within the double E loop, Asp-147 and Glu-149, confer specificity to protein arginine methyltransferase 7 (PRMT7. PMID: 25294873
    7. reducing expression of individual PRMT7 target DNA repair genes showed that only the catalytic subunit of DNA polymerase, POLD1, was able to resensitize PRMT7 knock-down cells to DNA-damaging agents. PMID: 22761421
    8. Human protein arginine methyltransferase 7 (PRMT7) is a type III enzyme forming omega-NG-monomethylated arginine residues. PMID: 22241471
    9. Here the authors report that H3R2 is also symmetrically dimethylated (H3R2me2s) by PRMT5 and PRMT7 and present in euchromatic regions. PMID: 22231400
    10. both domains are required for functionality PMID: 15044439
    11. PRMT7 (like PRMT5) is a Type II methyltransferase capable of producing symmetric dimethylarginine modifications in proteins. PMID: 15494416
    12. that in human cells, PRMT5 and PRMT7 are required for Sm protein sDMA modification, and that Sm protein symmetric dimethylarginine modification is required for snRNP biogenesis in human cells. PMID: 17709427

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  • 相關(guān)疾病：
    Short stature, brachydactyly, intellectual developmental disability, and seizures (SBIDDS)
  • 亞細(xì)胞定位：
    Cytoplasm, cytosol. Nucleus.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family, PRMT7 subfamily
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 25557

    OMIM: 610087

    KEGG: hsa:54496

    STRING: 9606.ENSP00000343103

    UniGene: Hs.640229



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