在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PRMT2 Antibody

PRMT2 Antibody

  • 中文名稱：
    PRMT2兔多克隆抗體
  • 貨號：
    CSB-PA229403
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA229403(PRMT2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA229403(PRMT2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PRMT2
  • 別名：
    ANM2_HUMAN antibody; EC 2.1.1. antibody; histone arginine N methyltransferase PRMT2 antibody; Histone-arginine N-methyltransferase PRMT2 antibody; HMT 1 antibody; HMT1 (hnRNP methyltransferase S. cerevisiae) like 1 antibody; HMT1 antibody; HMT1 hnRNP methyltransferase like 1 antibody; hnRNP methyltransferase (S. cerevisiae) like 1 antibody; hnRNP methyltransferase like 1 antibody; Hrmt1l1 antibody; MGC111373 antibody; PRMT 2 antibody; PRMT2 alpha antibody; prmt2 antibody; PRMT2 beta antibody; PRMT2 gamma antibody; PRMT2 protein antibody; PRMT2L2 antibody; Protein arginine methyltransferase 2 antibody; Protein arginine N methyltransferase 2 antibody; Protein arginine N-methyltransferase 2 antibody; Zf2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Fusion protein of Human PRMT2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
  • 基因功能參考文獻(xiàn)：
    1. Results show that tamoxifen resistance in breast cancer cells is connected with the downregulation of PRMT2 and the upregulation of ER-alpha36. Moreover, PRMT2 was able to interact with ER-alpha36 directly, suppress ER-alpha36 and downstream PI3K/Akt and MAPK/ERK signaling, reversing the tamoxifen resistance of breast cancer cells. PMID: 29620287
    2. Low splice variant of PRMT2 expression is associated with breast cancer. PMID: 28677794
    3. Cobl-mediated dendritic arborization required PRMT2, complex formation with PRMT2, and PRMT2's catalytic activity PMID: 29689199
    4. The PRMT2 interacts with SAM68 in cells and regulates its subcellular localization via the SH3 domain of PRMT2, prompting us to investigate the potential role of PRMT2 in BCL-X alternative splicing. PMID: 28057797
    5. This study demonstrates the role and significant correlation between a histone methyltransferase (PRMT2)-dependent signature, RORgamma, the cell-cycle regulation, DNA repair circuits, and breast cancer survival outcomes. PMID: 24911119
    6. This study uncovers the molecular mechanism of PRMT2 regulating the expression of CCND1 in invasive ductal breast carcinoma. PMID: 24292672
    7. characterization of 3 PRMT2 splice variants (PRMT2alpha, PRMT2beta, and PRMT2gamma) from breast cancer; these variants bind to ERalpha in vitro/in vivo; overall PRMT2 expression is upregulated in breast cancer and associated w/ ERalpha positivity PMID: 22093364
    8. Data suggest that post-transcriptional processing mechanism as alternative polyadenylation and splicing may play a crucial role in regulating human PRMT2 gene expression. PMID: 21820040
    9. the SH3 domain may mediate an interaction between PRMT1 and -2 in a methylation-dependent fashion PMID: 21851090
    10. PRMT2 is a novel ERalpha coactivator. PMID: 12039952
    11. PRMT2 inhibits NF-kappa B function and promotes apoptosis. PMID: 16648481
    12. ligand-dependent AR conformation is essential for the recruitment and nuclear translocation of PMRT2 which acts as AR-coactivator, presumably by arginine methylation. PMID: 17587566
    13. Here we report methylation activity from PRMT2 and compare it with PRMT1 activity using UPLC-MS/MS (ultra-performance liquid chromatography-tandem MS), gel electrophoresis, and thin-layer chromatography PMID: 19405910

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Isoform 1]: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus.; [Isoform PRMT2Alpha]: Nucleus. Note=Excluded from nucleolus.; [Isoform PRMT2Beta]: Cytoplasm. Nucleus. Nucleus, nucleolus.; [Isoform PRMT2Gamma]: Nucleus. Note=Excluded from nucleolus.; [Isoform PRMT2L2]: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family
  • 組織特異性：
    Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5186

    OMIM: 601961

    KEGG: hsa:3275

    STRING: 9606.ENSP00000347906

    UniGene: Hs.154163



主站蜘蛛池模板： 丰满少妇人妻hd高清大乳在线 | 国产亚洲精品久久久久的角色| 乱人伦人妻中文字幕无码| 精品夜夜澡人妻无码av| 女人裸露免费视频无遮挡网站| 免费人成视频在线播放视频 | 久久中文字幕人妻熟av女| 小辣椒福利视频导航| 337p亚洲日本中国大胆69| 久久99亚洲精品久久频| 成 人 免费观看网站| 国产午夜三级一区二区三| 成年性午夜无码免费视频| 嫩草欧美曰韩国产大片| 久久综合亚洲色hezyo社区| 成年女人午夜毛片免费视频| 少妇人妻陈艳和黑人教练| 久久久久国色av免费观看性色| 久久亚洲精品11p| 在线成人a毛片免费播放| 国产69精品久久久久孕妇| 老熟女重囗味hdxx70星空| 亚洲精品无码久久久久| 最新的国产成人精品2022| 在线亚洲97se亚洲综合在线| 午夜精品久久久久久久| 97免费公开在线视频| 久久久噜噜噜久久熟女色 | 爆乳2把你榨干哦ova在线观看| 欧美xxxx做受欧美| 久久久喷潮一区二区三区| 高清国产av一区二区三区| 国产女人好紧好爽| 国产gv在线观看受被做哭| 欧美日韩精品成人网站二区| 亚洲人成色77777| 国产午夜福利片| 97无码精品综合| 波多野结衣办公室33分钟| 国产精品毛片a∨一区二区三区 | 强伦人妻一区二区三区视频18|