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  4. PRKG2 (Ab-126) Antibody

PRKG2 (Ab-126) Antibody

  • 中文名稱：
    PRKG2 (Ab-126)兔多克隆抗體
  • 貨號：
    CSB-PA843898
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from 293 cells, treated with anisomycin (25μg/ml, 30mins), using PKG2 (Ab-126) antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PRKG2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized non-phosphopeptide derived from Human PKG2 around the phosphorylation site of serine 126 (G-V-S(p)-A-E).
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum. Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863. Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation.
  • 基因功能參考文獻：
    1. L-Arginine is a potential alternative to PKG II activation. PMID: 29401205
    2. Comparative analysis of the backbone hydrogen/deuterium exchange patterns in PKG II:8-pCPT-cGMP and previously reported PKG Ibeta:cGMP XN structures suggests that the ability of these agonists to activate PKG is related to how effectively they quench dynamics of the cyclic nucleotide binding pocket and the surrounding regions. PMID: 29517905
    3. the results indicated that PKG II could block c-Met activation via phosphorylating Ser985 PMID: 27147579
    4. PKG II inhibits EGFinduced activation of HER2 through binding with and causing threonine 686 phosphorylation of this oncogenic protein. PMID: 26676300
    5. The C-terminal cyclic nucleotide binding (CNB-B) domain of cGMP-dependent protein kinase II binds cGMP with higher affinity and selectivity when compared with its N-terminal CNB (CNB-A) domain. PMID: 26769964
    6. Han Chinese patients with rs10033237 polymorphism of cGKII/PRKG2 gene are more likely to suffer from gout. PMID: 25688884
    7. Our replication study suggests that cGKII is not involved in gout susceptibility. PMID: 24882840
    8. we determined a crystal structure of the PKG II LZ-Rab11b complex. The PKG II LZ domain presents a mostly nonpolar surface onto which Rab11b docks, through van der Waals interactions PMID: 25070890
    9. PKGII inhibits RhoA activity by binding to this small GTPase and causing phosphorylation at its Ser188 site. PMID: 24549567
    10. PKG II also inhibits the activation of the EGFR caused by diverse ligands of the receptor. PMID: 24534906
    11. type II cGMPdependent protein kinase prevented the EGF-induced phosphorylation/activation of ERK and JNK, but not the phosphorylation of p38MAPK induced by EGF. PMID: 22940826
    12. Downregulation of PKG2 was associated with malignant and benign breast tumors. PMID: 22791569
    13. The work presented here demonstrates a novel antiproliferative and prodifferentiation role for PKG2 in the colon. PMID: 22556146
    14. The results suggest that PKGII inhibits EGF-induced MAPK/JNK-mediated signal transduction and further confirmed that PKGII can block the activation of EGFR. PMID: 22427012
    15. PKG II inhibits the proliferation of gastric cancer cells through blocking EGF-triggered MAPK signal transduction. PMID: 22012247
    16. As an addition to PRKG2 and RASGEFIB genes, we propose to include BMP3 gene as the principal determinant of the observed common phenotype. PMID: 22303795
    17. Inhibition of cGMP-dependent protein kinase II by its own splice isoform PMID: 12054676
    18. results show that the fast phase of autophosphorylation of cGMP dependent protein kinase II has a small effect on its activity, whereas the secondary phase involving Ser126 phosphorylation may generate an active form PMID: 12764134
    19. Characterization of the 4q21 breakpoint revealed PRKG2 as the likely gene partner to PDGFRB in myeloproliferative disorders. PMID: 18262053
    20. Results suggest that the cGK II gene on chromosome 4q21 is most likely to harbour gout disease independently of hyperuricaemia and is inherited recessively. PMID: 18678579
    21. Regulation of epithelial sodium channels by cGMP/PKGII. PMID: 19359370
    22. PRKG2 inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines. PMID: 19543319

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  • 亞細胞定位：
    Apical cell membrane; Lipid-anchor.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, cGMP subfamily
  • 組織特異性：
    Highly concentrated in brain, lung and intestinal mucosa.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9416

    OMIM: 601591

    KEGG: hsa:5593

    STRING: 9606.ENSP00000264399

    UniGene: Hs.232044



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