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PRKD3 Antibody, FITC conjugated

  • 中文名稱:
    PRKD3兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào):
    CSB-PA018713LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PRKD3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    EPK 2 antibody; EPK2 antibody; KPCD3_HUMAN antibody; nPKC nu antibody; nPKC-nu antibody; nPKCnu antibody; nu antibody; PKCnu antibody; PKD 3 antibody; PKD3 antibody; PRK D3 antibody; PRKCN antibody; PRKD 3 antibody; Prkd3 antibody; Protein kinase C antibody; Protein kinase C nu antibody; Protein kinase C nu type antibody; Protein kinase D3 antibody; Protein kinase EPK 2 antibody; Protein kinase EPK2 antibody; Serine threonine protein kinase antibody; Serine/threonine protein kinase D3 antibody; Serine/threonine-protein kinase D3 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Serine/threonine-protein kinase D3 protein (326-510AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress.
  • 基因功能參考文獻(xiàn):
    1. Our findings suggest that abnormal PKD3 expression might contribute to hepatocellular carcinoma progression. Furthermore, high PKD3 expression predicts a poor prognosis in hepatocellular carcinoma patients after hepatectomy PMID: 28363424
    2. The enriched pathway analysis reveals that PRKD3 regulates pathways contributing to multiple cancer related events, including cell cycle, migration and others. PMID: 28656000
    3. None of the Polymorphous low-grade adenocarcinoma (PLGA) lacking PRKD1 somatic mutations or PRKD gene family rearrangements harboured somatic mutations in the kinase domains of the PRKD2 or PRKD3 genes. PMID: 26426580
    4. This study discovered and characterized a novel, highly conserved N-terminal domain, comprising 92 amino acids, which mediates dimerization of Protein Kinase D (PKD) isoforms, PKD1, PKD2, and PKD3 monomers. PMID: 27662904
    5. Studies indicate that the loss of protein kinase D PKD1 is thought to promote invasion and metastasis, while PKD2 and upregulated PKD3 to be positive regulators of proliferation. PMID: 26253275
    6. Loss of PKD2 enhanced KC proliferative potential while loss of PKD3 resulted in a progressive proliferation defect, loss of clonogenicity and diminished tissue regenerative ability. PMID: 25802335
    7. for the first time, PKD3 is implicated in the transcription activation of latent HIV-1 provirus, and our results revealed a molecular mechanism of prostratin-induced HIV-1 transcription via PKCepsilon/PKD3/NF-kappaB signaling pathway. PMID: 25136641
    8. Activation of PKD2 and further increase of PKD3 activity leads to additional phosphorylation and inhibition of endogenous phosphatase slingshot 1L. PMID: 24840177
    9. PKD3 in TNBC cells provides a molecular connection between the Golgi and endolysosomal compartments to enhance proliferative mTORC1-S6K1 signaling. PMID: 24337579
    10. PKD3 negatively regulates human airway epithelial barrier formation and integrity through down-regulation of claudin-1, which is a key component of tight junctions. PMID: 24265314
    11. PKD3 may contribute to the malignant progression of prostate cancer cells through negative regulation of MMP-7 expression. PMID: 20813660
    12. PKD3 contributes to the proliferation and malignant growth of androgen-dependent prostate cancer cells in part by upregulating PSA expression. PMID: 20813663
    13. We have identified PKD2 and PKD3, especially PKD3, as novel cell growth regulators in HCC1806 triple-negative breast cancer cells PMID: 23393329
    14. PKD antagonists inhibited differentiation and viability of human hematopoietic stem cells, and had less HDAC phosphorylation, confirming the need for PKD-HDAC signaling in erythropoiesis. PMID: 22983445
    15. phosphorylation of GIT1 on serine 46 by PKD3 represents a molecular switch by which GIT1 localization, paxillin trafficking, and cellular protrusive activity are regulated. PMID: 22893698
    16. Data demonstrate the functional role of protein kinase D1 and protein kinase D3 in modulating physiological responses to Ox1R activation. PMID: 20621130
    17. Novel isoforms regulate human keratinocyte differentiation by activating a p38 delta mitogen-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha. PMID: 12080077
    18. PKCnu is an important component of signaling pathways downstream from novel PKC enzymes after B-cell receptor engagement PMID: 12506120
    19. the effect of G protein-coupled receptor agonists on the regulatory properties, continuous shuttling, and intracellular distribution of Protein kinase C nu/protein kinase D3 PMID: 12676944
    20. specificity of different PKD isoforms in regulating protein trafficking from the trans-Golgi network PMID: 14743217
    21. PKD3 directly contributes to insulin-independent basal glucose uptake in L6 skeletal muscle cells. PMID: 15496505
    22. Expression of constitutively activated PKCeta caused Golgi fragmentation. PMID: 15824133
    23. the catalytic activity of PKD3 may regulate its nuclear import through autophosphorylation and/or interaction with another protein PMID: 16380377
    24. The vesicular distribution may be attributed in part to the direct interaction between PKD3 and vesicle-associated membrane protein VAMP2, through which PKD3 may regulate VAMP2 vesicle trafficking by facilitating its recruitment to the target membrane. PMID: 17196367
    25. A pathway comprising PKCs>Raf-1>MEK-1>ERK-1/-2 mediates the effect of gastrin on the CgA promoter, and strongly suggests that enhanced phosphorylation of Sp1 and CREB is crucial for CgA transactivation through the G protein-coupled CCK-B/gastrin receptor. PMID: 17889508
    26. The data suggest that protein kinase C contributes to the phosphorylation of influenza PB1 and NS1 proteins which appears to be functionally relevant for both viral RNA polymerase activity and efficient viral replication. PMID: 19264651

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  • 亞細(xì)胞定位:
    Cytoplasm. Membrane. Note=Translocation to the cell membrane is required for kinase activation.
  • 蛋白家族:
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, PKD subfamily
  • 組織特異性:
    Ubiquitous.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 9408

    OMIM: 607077

    KEGG: hsa:23683

    STRING: 9606.ENSP00000234179

    UniGene: Hs.660757



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