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  4. PRKAG3 Antibody

PRKAG3 Antibody

  • 中文名稱：
    PRKAG3兔多克隆抗體
  • 貨號：
    CSB-PA883379ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: Carbonic anhydrase 1 antibody at 6μg/ml + Rat brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 55, 52 kDa
      Observed band size: 55 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PRKAG3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    5 AMP activated protein kinase subunit gamma 3 antibody; 5''-AMP-activated protein kinase subunit gamma-3 antibody; AAKG3_HUMAN antibody; AMPK gamma 3 chain antibody; AMPK gamma3 antibody; AMPK subunit gamma-3 antibody; AMPKG3 antibody; PRKAG3 antibody; Protein kinase AMP activated gamma 3 non catalytic subunit antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human 5\'-AMP-activated protein kinase subunit gamma-3 protein (1-210AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism. It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
  • 基因功能參考文獻：
    1. PRKAG3-230 may be associated with sporadic Wolff-Parkinson-White (WPW) syndrome in a Taiwanese population. PMID: 27866917
    2. The mTOR pathway was significantly associated with overall and estrogen receptor-negative (ER-) breast cancer risk (P = 0.003 and 0.03, respectively). PRKAG3 (Padj = 0.0018) and RPS6KA3 (Padj = 0.061) were the leading genes for the associations with overall breast cancer risk and ER- breast cancer risk, respectively. PMID: 28582508
    3. Data suggest different gamma-isoforms in AMPK can have different effects on enzyme activation; here, activation of AMPK by compound 991 is greater if AMPK contains PRKAG2 versus PRKAG1 or PRKAG3. PMID: 28302767
    4. Low PRKAA2 expression is associated with follicular lymphoma. PMID: 23396962
    5. Through the enhancement of skeletal muscle glucose uptake and increased mitochondrial content, the R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3)may significantly enhance exercise performance. PMID: 20473479
    6. Purification and characterization of truncated human AMPK alpha 2 beta 2 gamma 3 heterotrimer from baculovirus-infected insect cells PMID: 19836452
    7. identified for the first time a mutation in the skeletal muscle-specific regulatory gamma(3) subunit of AMPK in humans PMID: 17878938
    8. the observation that the AMPKgamma3 isoform is expressed primarily in white skeletal muscle, in which it is the predominant gamma-isoform, strongly suggests that gamma3 has a key role in this tissue PMID: 14559719
    9. role of the AMPKgamma3 isoform in exercise-induced metabolic and gene regulatory responses in skeletal muscle PMID: 16306365
    10. data show that different mutations in gamma3 exert different effects on allosteric regulation of alpha2beta2gamma3 complex by AMP, whereas we find no evidence for their role in regulating the level of phosphorylation of alpha2 by upstream kinases. PMID: 17518971
    11. Genetic variability in PRKAG3 does not seem to have a major effect on glucose metabolism, but play a role in lipoprotein metabolism in humans. PMID: 17701023
    12. Variants in genes for AMPKalpha2 and AMPKgamma3 were not associated with PCOS or its component traits. PMID: 19574280
    13. Functional analysis of the pig counterpart. PMID: 10818001

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  • 蛋白家族：
    5'-AMP-activated protein kinase gamma subunit family
  • 組織特異性：
    Skeletal muscle, with weak expression in heart and pancreas.
  • 數據庫鏈接：

    HGNC: 9387

    OMIM: 604976

    KEGG: hsa:53632

    STRING: 9606.ENSP00000233944

    UniGene: Hs.591634



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