在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PREX2 Antibody, HRP conjugated

  • 中文名稱:
    PREX2兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA741122LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PREX2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    4 antibody; 5)-dependent Rac exchanger 2 antibody; 5-trisphosphate-dependent Rac exchanger 2 protein antibody; 6230420N16Rik antibody; DEP domain-containing protein 2 antibody; DEP.2 antibody; DEPDC2 antibody; FLJ12987 antibody; P-Rex2 antibody; Phosphatidylinositol 3 antibody; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 antibody; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein antibody; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 antibody; PREX2 antibody; PREX2_HUMAN antibody; PtdIns(3 antibody; PtdIns(3,4,5)-dependent Rac exchanger 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (1417-1592AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.
  • 基因功能參考文獻:
    1. Study demonstrates that miR-637 inhibites melanoma cell proliferation by activation of AKT signaling pathway and induces apoptosis through regulation of Bcl-2/Bax expression via targeting P-REX2a. PMID: 30213289
    2. MiR-338-3p suppresses the TNF-alpha-induced lipogenesis in sebocytes by targeting PREX2a and down-regulating PI3K/AKT signaling. PMID: 28597147
    3. complex signaling mechanisms that involve PREX2, PI3K/AKT/PTEN and downstream epigenetic machinery to deregulate expression of key cell cycle regulators PMID: 27111337
    4. PREX2 was identified as a frequently mutated gene in human melanoma. .. mutation of PREX2 can accelerate human melanoma growth. PMID: 28100393
    5. The rapid tumor onset observed in this replication attempt, compared to the original study, makes the detection of accelerated tumor growth in PREX2 expressing NRAS(G12D) melanocytes extremely difficult. PMID: 28100394
    6. Elevated PREX2 protein expression is associated with pathogenesis of hepatocellular carcinoma. PMID: 28205209
    7. knockdown of PREX2a may effectively inhibit the malignant phenotype of glioma. PMID: 26795161
    8. The results of the present study suggested that PREX2a may act as an oncogene in osteosarcoma via the inhibition of PTEN activity and activation of PI3K signaling. PMID: 26718453
    9. findings identify PREX2 as a mediator of NRAS-mutant melanoma development that acts through the PI3K/PTEN/Akt pathway to regulate gene expression of a cell cycle regulator PMID: 26884185
    10. second messengers activate the Rac1 signal, which sets in motion a cascade whereby PAKs phosphorylate and negatively regulate PREX2 to decrease Rac1 activation. PMID: 26438819
    11. PREX2 mutants are likely selected in cancer to escape PTEN-mediated inhibition of invasion. PMID: 25829446
    12. CXCL9 is involved in the invasion ability of hepatocellular carcinoma cells possibly through up-regulation of its potential effector PREX2. PMID: 25151370
    13. Results demonstrate that miR-338-3p affects gastric cancer progression through PTEN-AKT signaling by targeting P-Rex2a in gastric cancer cells PMID: 24375644
    14. P-REX2 PH-domain-mediated inhibition of PTEN has a role in regulating insulin sensitivity and glucose homeostasis PMID: 24367090
    15. MiR-338-3p affects the PTEN/Akt pathway by down-regulating PREX2a. PMID: 24140344
    16. Analysis of whole-genome sequence data identified PREX2 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2)--a PTEN-interacting protein and negative regulator of PTEN in breast cancer--as a significantly mutated gene with a mutation frequency of approximately 14% in an independent extension cohort of 107 human melanomas PMID: 22622578
    17. suggests that aberrant control of PTEN by P-REX2a may represent a key tumorigenic mechanism, in agreement with recent studies supporting the pathological relevance of several other proposed PTEN regulators PMID: 19861688
    18. P-REX2 may serve as a novel link between Rac activation and the PI-3 kinase pathway. PMID: 15304342
    19. P-Rex2 is a 183 kDa protein that activates the small GTPase Rac and is regulated by phosphatidylinositol (3,4,5)-trisphosphate. PMID: 15304343
    20. the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2 has a role in substrate specificity and recognition PMID: 15897194
    21. identified P-REX2a as a PTEN-interacting protein; P-REX2a inhibited PTEN lipid phosphatase activity & stimulated the PI3K pathway only in the presence of PTEN; P-REX2a is a component of the PI3K pathway that can antagonize PTEN in cancer cells PMID: 19729658

    顯示更多

    收起更多

  • 組織特異性:
    Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart.
  • 數據庫鏈接:

    HGNC: 22950

    OMIM: 612139

    KEGG: hsa:80243

    STRING: 9606.ENSP00000288368

    UniGene: Hs.169943



主站蜘蛛池模板: 亚洲精品国产成人无码区a片| 亚洲欧美中文日韩在线视频一| 国内熟女啪啪自拍| 久久超碰极品视觉盛宴 | 香蕉成人伊视频在线观看| 无码h黄动漫在线播放网站| 黑人与中国少妇xxxx视频| 无码国产精品久久一区免费| 人人澡超碰碰97碰碰碰| 久久久久国产精品人妻aⅴ毛片| 亚洲综合精品香蕉久久网| 国产熟妇乱xxxxx大屁股网| 少妇伦子伦情品无吗| 综合激情久久综合激情| 亚洲色播永久网址大全| 久久婷婷五月综合97色| 欧美私人情侣网站| 永久久久免费人妻精品| 男人边吃奶边揉好爽免费视频 | 玩弄少妇人妻中文字幕| 日韩欧美一区二区三区免费观看| 精品国精品自拍自在线| 亚洲大尺度专区无码浪潮av| 国产免费又色又爽粗视频| 韩国精品福利一区二区三区| 日韩亚洲中字无码一区二区三区| 最新国产麻豆aⅴ精品无码| 欧美日韩在线视频| 中国女人大白屁股ass| 久久精品道一区二区三区| 国产裸体舞一区二区三区| 免费无码成人片| 成人爽a毛片免费看| 成人无码av一区二区| 一本一本久久a久久精品综合| 国产一区二区无码蜜芽精品| 欧美成aⅴ人高清ww| 久久综合九色综合欧美98 | 女人下边被添全过视频的网址| 特级a做爰全过程片| 性按摩无码中文|