在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PRDM14 Antibody

  • 中文名稱:
    PRDM14兔多克隆抗體
  • 貨號:
    CSB-PA863934LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA863934LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA863934LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PRDM14 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PRDM14
  • 別名:
    MGC59730 antibody; PFM 11 antibody; PFM11 antibody; PR domain containing 14 antibody; PR domain zinc finger protein 14 antibody; PR domain-containing protein 14 antibody; PRD14_HUMAN antibody; PRDM 14 antibody; PRDM14 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human PR domain zinc finger protein 14 protein (301-571AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,PRDM14 Antibody (CSB-PA863934LA01HU),的標記方式是Non-conjugated。對于PRDM14 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA863934LB01HU PRDM14 Antibody, HRP conjugated ELISA
    FITC CSB-PA863934LC01HU PRDM14 Antibody, FITC conjugated
    Biotin CSB-PA863934LD01HU PRDM14 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation. Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.
  • 基因功能參考文獻:
    1. Our results suggest that PRDM14 serves as an initial trigger for epigenetic changes and hyperdynamic plasticity in tumors via bivalent chromatin domains. PMID: 28423353
    2. Results identified GRP78 and HSP90a as binding partners of PRDM14 in triple-negative breast cancer cells, and all participate in cancer regulation. The interactions were direct and required the C-terminal region including the zinc finger motifs of PRDM14. PMID: 29178343
    3. miR-424-->cdc42-->prdm14 axis as a key molecular signalling cascade that might influence breast cancer progression in diabetic patients through hyperactivation of cancer stem cells. PMID: 29024936
    4. High expression of PRDM14 is associated with liver metastasis in pancreatic cancer. PMID: 28498896
    5. PRDM14 role in cell proliferation and cell migration PMID: 27693212
    6. PRDM14 bears a single PR domain and six tandemly repeated zinc fi ngers, which is involved in the process of the deacetylation and methylation of the histone, and is involved in the formation of tumor . [review] PMID: 26903163
    7. In response to cytokines, pluripotent stem cells differentiate first into a heterogeneous mesoderm-like cell population and then into Primordial Germ cell-Like Cells, which exhibit minimal PRDM14 expression. PMID: 25750208
    8. The contribution of methylation-mediated gene silencing of PRDM14 to apoptosis evasion in HPV-positive cancer cells offers novel therapeutic options for HPV-induced cancers. PMID: 25233927
    9. PRDM14 associated with cell differentiation in NSCLC. PMID: 23690269
    10. Study reveals a repressive role of PRDM14 in the maintenance and induction of pluripotency and identifies PRDM14 as a new regulator of PRC2. PMID: 23280602
    11. The high expression of PRDM14 in non-small cell lung cancer is associated with differentiation and histological type. PMID: 20840815
    12. novel hESC regulators wherein PRDM14 exemplifies a key transcription factor required for the maintenance of hESC identity and the reacquisition of pluripotency in human somatic cells PMID: 20953172
    13. PRDM14 mRNA is overexpressed in about two thirds of breast cancers; moreover, immunohistochemical analysis showed that expression of PRDM14 protein is also up-regulated. PMID: 17942894
    14. These results suggest that PRDM14 is involved in the maintenance of the self-renewal of human ES cells by suppression of gene expression. PMID: 18194669

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Class V-like SAM-binding methyltransferase superfamily
  • 組織特異性:
    Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level).
  • 數據庫鏈接:

    HGNC: 14001

    OMIM: 611781

    KEGG: hsa:63978

    STRING: 9606.ENSP00000276594

    UniGene: Hs.736037



主站蜘蛛池模板: 欧美在线看片a免费观看| 亚洲国产欧美在线成人aaaa| 精品无码国产一区二区三区av| 在线亚洲人成电影网站色www| 日韩av无码一区二区三区| 欧美国产日韩a在线观看| 在线观看免费人成视频网| 日韩99在线 | 中文| 亚洲日韩欧洲乱码av夜夜摸| 国产成人精品综合久久久久| 国产精品美脚玉足脚交| 免费人成在线观看网站品爱网| 九九综合va免费看| 久久综合精品国产二区无码| 无码少妇a片一区二区三区| 国产高潮又爽又刺激的视频| 国产高潮流白浆视频| 无码精品国产va在线观看| 国产精品老热丝在线观看| 成 人 在 线 免费观看| 日韩内射激情视频在线播放免费| 亚州日本乱码一区二区三区| 性一交一乱一乱一视频| 波多野结衣美乳人妻hd电影欧美 | 亚洲爆乳www无码专区| 久久www成人免费网站| 婷婷网色偷偷亚洲男人甘肃| 人妻夜夜添夜夜无码av| 国产精品久久777777| 国产成人亚洲精品另类动态| 无码人妻在线一区二区三区免费 | 中文字幕无码第1页| 久久婷婷五月综合色国产香蕉| 国产精品尹人在线观看| 久久久精品94久久精品| 夜夜影院未满十八勿进| 国产日产欧产精品精品蜜芽| 色伦专区97中文字幕| 伊人久久综合色| 久久人人爽人人爽人人片av麻烦 | 免费国产黄网站在线观看可以下载 |