在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PRAME Antibody, FITC conjugated

Unavailable
  • 中文名稱:
    PRAME兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA018603LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PRAME Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    4930534P07Rik antibody; Cancer/testis antigen 130 antibody; CT130 antibody; MAPE antibody; Melanoma antigen preferentially expressed in tumors antibody; OIP 4 antibody; OIP-4 antibody; OIP4 antibody; OPA interacting protein 4 antibody; Opa interacting protein OIP4 antibody; OPA-interacting protein 4 antibody; PRAME antibody; PRAME_HUMAN antibody; Preferentially expressed antigen in melanoma antibody; Preferentially expressed antigen of melanoma antibody; RP23-250F8.3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Melanoma antigen preferentially expressed in tumors protein (1-509AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation. Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.
  • 基因功能參考文獻:
    1. Knockdown PRAME in HCC cells, increased cell apoptosis was correlated with the proportion of cells in G0/G1 stage, activated p53 mediated apoptosis, and increased cyclin p21 expression. PMID: 29439259
    2. PRAME is frequently expressed in epithelial ovarian cancer at the mRNA and protein levels, and DNA methylation is a key mechanism regulating its expression. PMID: 27322684
    3. PRAME is aberrantly hypomethylated and activated in Class 1 and Class 2 uveal melanomas and is associated with increased metastatic risk in both classes PMID: 27486988
    4. To investigate the impact of gene copy number variation on PRAME expression, plasma cells were sorted from 50 newly diagnosed multiple myeloma patients and 8 healthy volunteers to measure PRAME transcript levels and gene copy numbers by real-time quantitative polymerase chain reaction. PMID: 28953414
    5. Tumor antigen PRAME is up-regulated by MZF1 in cooperation with DNA hypomethylation in melanoma cells. PMID: 28634046
    6. Results support the potential utility of NY-ESO-1, PRAME, and MAGEA4 as targets for immunotherapy and as ancillary prognostic parameters in synovial sarcomas. PMID: 27993576
    7. PRAME plays a role in preventing the invasion and metastasis of lung adenocarcinoma PMID: 27391090
    8. PRAME is expressed in many primary and metastatic UMs, and about half of the metastatic UMs coexpress PRAME and HLA class I. PMID: 28448663
    9. PRAME is a downstream factor of SOX17 and LIN28 in regulating pluripotency and suppressing somatic/germ cell differentiation in primordial germ cells, germ cell neoplasia in situ, and seminomas. PMID: 27441500
    10. In line with its roles in controlling cell growth, RPAME regulates multiple critical cell-growth related genes, including IGF1R oncogene. IGF1R up-regulation contributes to increase of cell growth upon the knockdown of PRAME. PMID: 27241212
    11. This study demonstrates that PRAME functions as a tumor suppressor in breast cancer. PMID: 27632898
    12. PRAME is an independent prognostic biomarker in Uveal melanoma , which identifies increased metastatic risk in patients with Class 1 or disomy 3 tumors. PMID: 26933176
    13. Leukemias expressing high levels of PRAME had higher levels of cell death by regulating S100A4/p53 signaling. PMID: 27049257
    14. Our results suggest that the leukemias expressing high levels of PRAME has favorable prognosis PMID: 26823776
    15. PRAME expression is considered as a poor prognostic parameter in HL. PMID: 26044287
    16. PRAME immunoreactivity in myeloid leukemia (ML) of Down syndrome (DS) is largely due to the non-blast components, while PRAME immunoreactivity in blasts of Transient abnormal myelopoiesis (TAM) is not restricted to cases that progress to ML of DS. PMID: 25887863
    17. This study shows the prognostic significance of PRAME expression in diffuse large B-cell lymphoma patients treated with R-CHOP therapy. PMID: 24820636
    18. results suggested that PRAME was a predictor for better outcome, could be a useful target for immunotherapy, and might represent a candidate marker for the monitoring of minimal residual disease PMID: 24600975
    19. elevated PRAME expression in head and neck squamous cell carcinoma PMID: 23905893
    20. PRAME and WT1 transcripts constitute a good molecular marker combination for monitoring minimal residual disease in MDS. PMID: 23110703
    21. PRAME impairs differentiation and increases proliferation likely via blocking retinoic acid receptor signaling. PMID: 23444226
    22. PRAME is upregulated by signalling pathways that are activated in response to infection/inflammation. PMID: 23460923
    23. The complex PRAME/EZH2 is able to repress TRAIL expression, in a cancer-specific manner; inhibition of PRAME/EZH2 releases apoptosis-mediating TRAIL. (Review) PMID: 23228130
    24. PRAME and its paralogs are leucine rich repeat proteins. Structure predictions suggest PRAME resembles the extracellular domains of TLR3 and TLR4, or intracellular NALP family. This suggests PRAME may have a role in sensing Pathogen Associated Molecular Patterns (PAMPs). PMID: 23460923
    25. PRAME expression in leukaemic cell lines is upregulated by IFN gamma and LPS, suggesting a possible role in immune responses. PRAME associates with Elongin BC complexes by binding Elongin C, and co-localises to the Golgi network. Nuclear PRAME interacts with Histone H3. The results suggest that PRAME has dual roles in gene regulation in the nucleus and protein turnover trafficking in the Golgi PMID: 23460923
    26. Knock-down of PRAME increases retinoic acid signaling and cytotoxic drug sensitivity of Hodgkin lymphoma cells. PMID: 23409080
    27. a novel link between the oncoprotein PRAME and the conserved EKC complex PMID: 22912744
    28. PRAME as biomarkers for solid tumor PMID: 23075240
    29. NYESO-1/LAGE-1s and PRAME are targets for antigen specific T cells in chondrosarcoma following treatment with 5-Aza-2-deoxycitabine PMID: 22384167
    30. PRAME expression is regulated at the epigenetic level. For this reason inhibitors of DNA methylation, such as 5-azacytidine, can modulate the expression of this tumor associated antigen. PMID: 22503131
    31. Studies suggest that activated human gammadelta T cells can efficiently present PRAME and STEAP1-derived epitopes and allow breaking tolerance against these tumor-associated self-antigens. PMID: 21928126
    32. these results suggest that PRAME plays an important role in cell proliferation and disease progression in osteosarcoma. PMID: 22390931
    33. the expansion of the PRAME family occurred in both autosomes and sex chromosomes PMID: 21347312
    34. PRAME effectively differentiates mullerian carcinoma from malignant mesothelioma at the mRNA and protein levels. PMID: 22261449
    35. PRAME expression might be related to distinct patterns of tumorigenesis PMID: 21691740
    36. PRAME plays an important role in disease progression in acute leukemia. PMID: 21550659
    37. The authors applied protein-complex purification strategies and identified PRAME as a substrate recognition subunit of a Cullin2-based E3 ubiquitin ligase. PMID: 21822215
    38. The level of prame gene transcript increases in chronic myeloid leukemia which associates with disease progression. PMID: 20723287
    39. The cytotoxic activity of our PRAME-specific CTLs was directed not only against leukemic blasts, but also against leukemic progenitor cells as assessed by colony-forming-inhibition assays, which have been implicated in leukemia relapse. PMID: 21278353
    40. PRAME may be involved in the tumorigenic process in a wide range of cancers, at least in part by blocking the tumor suppressor pathway mediated by TRAIL expression. PMID: 20838376
    41. Results showed the expression of MCSP and PRAME in conjunctival melanoma and benign conjunctival nevi and showed that MCSP and PRAME were differentially expressed in both and can help to differentiate the lesions diagnostically. PMID: 20805128
    42. The PRAME transcript was highly expressed in acute myeloid leukemia patients and was a favorable marker of prognosis. PMID: 20376794
    43. PRAME mRNA could be used to monitor minimal residual disease in newly diagnosed acute myeloid leukemia patients. PMID: 19035174
    44. E2F4, PHACTR3, PRAME family member and CDH12 most probably play important role in non-small-cell lung cancer geneses PMID: 19473719
    45. expression of PRAME is an indicator of favorable prognosis and could be a useful tool for monitoring minimal residual disease in childhood AML. PMID: 11943337
    46. PRAME gene expression in childhood acute lymphoblastic leukemia PMID: 12419593
    47. PRAME is highly expressed in primary advanced neuroblastoma PMID: 15240516
    48. The overexpression of PRAME protein frequently observed in human cancers confers growth or survival advantages by antagonizing retinoic acid receptor(RAR) signaling. PMID: 16179254
    49. The results suggest that the analysis of PRAME protein may contribute for the distinction between normal and leukemic cells in chronic lymphoproliferative disorders(CLD), and that PRAME may be a potential target for therapy. PMID: 16620968
    50. PRAME is expressed in acute myeloblastic leukaemia PMID: 16681423

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome. Cytoplasm. Golgi apparatus. Cell membrane.
  • 蛋白家族:
    PRAME family
  • 組織特異性:
    Expressed in testis. Detected in samples of kidney, brain and skin.
  • 數據庫鏈接:

    HGNC: 9336

    OMIM: 606021

    KEGG: hsa:23532

    STRING: 9606.ENSP00000381726

    UniGene: Hs.30743



主站蜘蛛池模板: 成在线人免费视频播放| 无码精品久久久久久人妻中字| 国产免费人成在线视频网站| 亚洲国产成人爱av网站| 色狠狠色狠狠综合天天| 久久久www成人免费毛片| 亚洲欧洲av一区二区久久| 亚洲乱码中文字幕小综合| 欧美精品黑人粗大视频| 亚洲国产日韩欧美一区二区三区| 久久老子午夜精品无码怎么打| 午夜免费啪视频观看视频| 国产猛烈高潮尖叫视频免费| 99精品国产在热久久无码| 噜噜噜av久久av苍井空| 久久精品国产免费播| 亚洲成a人片在线观看www| 正在播放重口老熟女露脸| 亚洲超清无码制服丝袜无广告| 国产又a又黄又潮娇喘视频| 精品久久久久久久久久中文字幕 | 久久aⅴ无码av高潮av喷吹| 国产在线看片免费观看| 国产成人一区二区三区免费| 亚洲午夜国产精品无码老牛影视| 国产午夜理论片不卡| 国产又色又爽又黄的视频在线观看| 无码国内精品久久人妻| 日日拍夜夜嗷嗷叫国产| 色天使亚洲综合一区二区| 亚洲精品无码ma在线观看| 午夜阳光精品一区二区三区| 中文字幕人妻熟女人妻a片| 久久国产人妻一区二区免费| 久青草国产97香蕉在线视频| 波多野结衣乳巨码无在线观看| 老熟妻内射精品一区| 亚洲精品国产一区二区在线观看| 久久久精品人妻一区二区三区蜜桃 | 亚洲乱码无人区卡1卡2卡3| 亚洲性夜色噜噜噜在线观看不卡|