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PPRC1 Antibody

  • 中文名稱:
    PPRC1兔多克隆抗體
  • 貨號:
    CSB-PA008323
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PPRC1
  • 別名:
    PPRC1 antibody; KIAA0595 antibody; Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 antibody; PGC-1-related coactivator antibody; PRC antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human PRC.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.
  • 基因功能參考文獻:
    1. PRC and c-MYC can act in concert through Akt-GSK-3 signaling to reprogram gene expression in response to mitochondrial stress. PMID: 27789709
    2. PRC is a negative regulator of endothelial inflammation; it negatively regulates endothelial adhesion of monocytes via inhibition of NF kappaB activity PMID: 23954632
    3. A general role for PRC in the adaptive response to cellular dysfunction. PMID: 23364789
    4. PRC has a role in the rapid modulation of metabolic functions in response to the status of the cell cycle PMID: 19956726
    5. overexpression of the PRC pathway is responsible for mitochondrial proliferation in the context of thyroid oncocytoma PMID: 14550271
    6. PGC-1 has a role in regulating gluconeogenic genes along with HNF-4alpha and SREBP-1 PMID: 14722127
    7. This review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure. PMID: 16511594
    8. Upregulation of PGC-1alpha and PGC-1beta in the colorectal tumor cells can be part of an adaptation mechanism to help overcome the severe consequences of mtDNA mutations on oxidative phosphorylation. PMID: 17341490
    9. These results revealed that bile acid inhibits the promoter activity of PGC-1 in an SHP-dependent manner. PMID: 17390079
    10. Activation of the SIRT1/PGC-1 pathway, in a metabolic context promotes mitochondrial function and this pathway plays a role in neurodegerative disease. Review. PMID: 17937892
    11. The results are consistent with a pathway whereby PRC regulates NRF-2-dependent genes through a multiprotein complex involving HCF-1. PMID: 18343819
    12. support a role for PRC in the integration of pathways directing mitochondrial respiratory function and cell growth PMID: 19036724
    13. Coordinate regulation of nucleus-encoded mitochondrial transcription factors by NRFs and PGC-1 family coactivators is essential to the control of mitochondrial biogenesis PMID: 15684387

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  • 亞細胞定位:
    Nucleus.
  • 組織特異性:
    Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.
  • 數據庫鏈接:

    HGNC: 30025

    OMIM: 617462

    KEGG: hsa:23082

    STRING: 9606.ENSP00000278070

    UniGene: Hs.533551



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