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  4. PPP4R2 Antibody

PPP4R2 Antibody

  • 中文名稱：
    PPP4R2兔多克隆抗體
  • 貨號：
    CSB-PA007474
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of K562 cells using PP4R2 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    PPP4R2
  • 別名：
    BE691708 antibody; C230060M08Rik antibody; MGC131930 antibody; PP4R2 antibody; PP4R2_HUMAN antibody; PPP4R2 antibody; protein phosphatase 4, regulatory subunit 2 antibody; Serine/threonine protein phosphatase 4 regulatory subunit 2 antibody; Serine/threonine-protein phosphatase 4 regulatory subunit 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Monkey
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PP4R2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.
  • 基因功能參考文獻：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that PPP4R2 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. Our results suggest that PATZ1 and PP4R2 provide negative feedback on IKK/NF-kappaB signaling to prevent cancer cells from over-stimulation from cellular stimuli PMID: 27391343
    3. PPP4R2 affects the survival of neuronal cells in response to DNA damage. PMID: 22559936
    4. PP4R2, a regulatory subunit of PP4, mediates the DNA damage-dependent association between RPA2 and the PP4C catalytic subunit. PMID: 20154705
  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2.
  • 蛋白家族：
    PPP4R2 family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 18296

    OMIM: 613822

    KEGG: hsa:151987

    STRING: 9606.ENSP00000349124

    UniGene: Hs.431092



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