在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PPP4C Antibody

PPP4C Antibody

  • 中文名稱：
    PPP4C兔多克隆抗體
  • 貨號：
    CSB-PA018577GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    PP X antibody; PP-X antibody; Pp4 antibody; PP4C antibody; PP4C_HUMAN antibody; PPH3 antibody; PPP4 antibody; ppp4c antibody; PPX antibody; protein phosphatase 4 (formerly X), catalytic subunit antibody; Protein phosphatase 4 catalytic subunit antibody; Protein phosphatase X antibody; protein phosphatase X, catalytic subunit antibody; Serine/threonine protein phosphatase 4 catalytic subunit antibody; Serine/threonine-protein phosphatase 4 catalytic subunit antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PPP4C
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
  • 基因功能參考文獻：
    1. PP4 regulates breast cancer cell survival and identifies a novel PP4c-PEA15 signalling axis in the control of breast cancer cell survival. PMID: 27317964
    2. Data show that protein phosphatase 4 catalytic subunit (PP4C) knockdown decreases glioma cell proliferation. PMID: 27059736
    3. mutual regulatory mechanisms exist between PP4 and SAF-A. Interactions between PP4 and SAF-A played a role in prometaphase/metaphase transition. PMID: 27041735
    4. These data suggested a potential role of PP4C in tumor progression. PMID: 25927939
    5. Stathmin plays an essential role of in Merkel cell polyomavirus small tumor antigen-mediated microtubule destabilization and cell motility and this process is regulated by cellular phosphatase catalytic subunit of protein phosphatase 4. PMID: 25320307
    6. PP4 and Wip1 are differentially required to counteract the p53-dependent cell cycle arrest in G1 and G2, by antagonizing early or late p53-mediated responses, respectively PMID: 24711418
    7. Results show PP4C as a fostriecin-sensitive phosphatase and demonstrate that the suppression of PP4C triggers mitotic slippage/apoptosis. PMID: 23671329
    8. Data indicate that the major phosphatase responsible for dephosphorylation of of BAF Ser-4 to be protein phosphatase 4 catalytic subunit. PMID: 24265311
    9. Recombinant gamma-tubulin can be phosphorylated by Cdk1-cyclin B or Brsk1 and dephosphorylated by Ppp4c-R2-R3A in vitro. PMID: 23966160
    10. PP4c is a key regulator of cortical development that changes the orientation of progenitor division responsible for the transition between symmetric and asymmetric cell division. PMID: 23830831
    11. Overexpression of PP4C is associated with poor prognosis in patients with stage II pancreatic ductal adenocarcinoma. PMID: 22665577
    12. PP4R1 and PP4c Cooperate to Catalyze IKK Dephosphorylation PMID: 23084358
    13. PP4C and KAP1 are in the same epistasis group, and PP4 is involved in NHEJ-mediated DSB repair, possibly through regulating the phosphorylation status of KAP1. PMID: 22732494
    14. The authors devised a novel proteomic strategy for systematic identification of proteins dephosphorylated by PP4C and identified KRAB-domain-associated protein 1 (KAP-1) as a substrate. PMID: 22491012
    15. PP4R2, a regulatory subunit of PP4, mediates the DNA damage-dependent association between RPA2 and the PP4C catalytic subunit. PMID: 20154705
    16. Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs PMID: 12668731
    17. protein phosphatase 4 has a role in NF-kappaB p65 Thr dephosphorylation PMID: 15073167
    18. IRS-4 is subject to regulation by TNF-alpha, and PP4 mediates TNF-alpha-induced degradation of IRS-4 PMID: 15331607
    19. PP4 is a positive regulator for HPK1 and the HPK1-JNK signaling pathway PMID: 15364934
    20. Our work uncovers a unique regulatory mechanism of MT organization by PP4c through its targets Cdk1 and NDEL1 via regulation of katanin p60 distribution. PMID: 18347064
    21. Analysis of the role of the serine/threonine protein phosphatase, protein phosphatase 4, in controlling the apoptosis of HEK 293 T cells, using the complementary techniques of gene over-expression and down regulation through RNA interference. PMID: 18424272
    22. The results suggest that Ppp4c-R2-R3 complexes may co-ordinate centrosome maturation and cell migration via regulation of RhoGTPases. PMID: 18487071
    23. A three-protein PP4 phosphatase complex in mammalian cells, containing PP4C, PP4R2, and PP4R3beta, specifically dephosphorylates ATR-mediated gamma-H2AX generated during DNA replication. PMID: 18614045
    24. PP4R4 forms a novel cytosolic complex with PP4c, independent from the complexes containing PP4R1, PP4R2.PP4R3, and alpha4, and the regulatory subunits of PP4c have evolved different modes of interaction with the catalytic subunit PMID: 18715871
    25. An evolutionarily conserved gamma histone 2AX phosphatase active on both DNA-damaged and undamaged chromatin. PMID: 18758438
    26. PP4 activity significantly affects the mutation rate in leukemic T-cells, indicating that PP4 dysfunction may be important in the development and progression of leukemia PMID: 19539371

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    PPP phosphatase family, PP-4 (PP-X) subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9319

    OMIM: 602035

    KEGG: hsa:5531

    STRING: 9606.ENSP00000279387

    UniGene: Hs.534338



主站蜘蛛池模板： 国产蜜芽尤物在线一区| 狠狠色综合激情丁香五月| 99久久人妻无码精品系列| 中文在线а天堂| 久久久噜噜噜久久熟女色 | 真人性生交免费视频| 国产成人最新三级在线视频| 国产国产裸模裸模私拍视频| 国产亚洲日韩在线a不卡| 法国伦理少妇愉情| 日韩一区二区在线观看视频 | 最新在线精品国自产拍福利| 国产精品.xx视频.xxtv| 欧美三级欧美成人高清| 亚洲国产成人精品无码一区二区| 欧洲美女黑人粗性暴交| 少妇一边呻吟一边说使劲视频 | 国产精品乱码在线观看| 欧美人妻体内射射| 亚洲国产精品ⅴa在线播放| 老熟妇仑乱一区二区视頻| 国内精品久久久久久久久电影网| 中美日韩毛片免费播放| 377人体粉嫩噜噜噜| 国内精品国产三级国产av| 国产高清乱码又大又圆| 亚洲熟女av乱码在线观看漫画| 秋霞特色aa大片| 国产99久一区二区三区a片| 一色屋精品视频在线观看免费| 综合亚洲桃色第一影院| 色翁荡熄又大又硬又粗又视频| 亚洲精品人成网线在线播放va| 亚洲精品国产自在现线最新| 久久精品成人亚洲另类欧美| 成人性能视频在线| 风韵人妻丰满熟妇老熟女| 久热爱精品视频线路一| 99久久久无码国产精品不卡| 日韩精品av一区二区三区| 国产午夜精品一二区理论影院|