在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PPP2R5C Antibody

  • 中文名稱:
    PPP2R5C Antibody
  • 貨號:
    CSB-PA619761GA01HU
  • 規格:
    3900
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PPP2R5C Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    2A5G_HUMAN antibody; B' alpha regulatory subunit antibody; B56G antibody; KIAA0044 antibody; MGC23064 antibody; PP2A B subunit B' gamma isoform antibody; PP2A B subunit B56 gamma isoform antibody; PP2A B subunit isoform B' gamma antibody; PP2A B subunit isoform B''-gamma antibody; PP2A B subunit isoform B56-gamma antibody; PP2A B subunit isoform PR61-gamma antibody; PP2A B subunit isoform R5-gamma antibody; PP2A B subunit PR61 gamma isoform antibody; PP2A B subunit R5 gamma isoform antibody; Ppp2r5c antibody; PR61G antibody; Protein phosphatase 2 regulatory subunit B (B56) gamma isoform antibody; Protein phosphatase 2 regulatory subunit B' gamma antibody; Protein phosphatase 2; regulatory subunit B'; gamma isoform antibody; Renal carcinoma antigen NY REN 29 antibody; Renal carcinoma antigen NY-REN-29 antibody; Serine/threonine protein phosphatase 2A 56 kDa regulatory subunit gamma isoform antibody; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform protein (1-380AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
  • 基因功能參考文獻:
    1. PPP2R5C deletion or EGFR mutation that could be responsible for IER3/pERK overexpression was found in at least 8 cases (67% or more) of lung adenocarcinoma. PMID: 26986830
    2. our data suggest that hepatic PPP2R5C represents an important factor in the functional wiring of energy metabolism and the maintenance of a metabolically healthy state. PMID: 26440364
    3. propose that the mechanism for proliferation inhibition and increased apoptosis of K562 cells following PPP2R5C suppression may be related to the alteration of expression profiles of BRAF, AKT2, AKT3, NFKB2 and STAT3 genes PMID: 25888193
    4. Differential expression of the transcripts PPP2R5C connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes. PMID: 25884766
    5. KIF4A and PP2A-B56G and -B56E create a spatially restricted negative feedback loop counteracting Aurora B in anaphase. PMID: 25512391
    6. Data indicate that the regulatory PP2A subunit B56gamma mediates suppression of NF-kappaB resulting in increased NF-kappaB target gene expression in T cells. PMID: 24719332
    7. Results show that mutations lost B56gamma tumor-suppressive activity by two distinct mechanisms: one is by disrupting interactions with the PP2A AC core and the other with B56gamma-PP2A substrates (p53 and unknown proteins). PMID: 23723076
    8. PPP2R5C-siRNA treatment altered gene expression profiles in malignant T cells PMID: 23941244
    9. structural insight into the PP2A holoenzyme assembly and emphasizes the importance of HEAT repeat 1 in B56gamma-PP2A tumor-suppressive function PMID: 22315229
    10. Overexpression of PPP2R5C in T-cell malignancy as well as in myeloid leukemia cells might relate to its proliferation and differentiation. PMID: 21548944
    11. ataxia-telangiectasia mutated (ATM) directly phosphorylates and specifically regulates B56gamma3, B56gamma2 and B56delta, after DNA damage. PMID: 21460856
    12. the dynamic nuclear distribution of the B56gamma3 regulatory subunit controls nuclear PP2A activity, which regulates cell cycle controllers, such as p27, to restrain cell cycle progression, and may be responsible for the tumor suppressor function of PP2A PMID: 20448040
    13. a mechanistic basis for the p53-dependent and -independent functions of B56gamma-PP2A PMID: 20473327
    14. B56gamma1 alters the dynamic assembly/disassembly process of nuclear speckles in heart cells. PMID: 15778281
    15. Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A PMID: 16524888
    16. B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. PMID: 17245430
    17. PP2A-B56gamma1 phosphatase complexes have a role in cardiac local signaling PMID: 17663574
    18. show an important link between ATM activity and the tumor-suppressive function of B56gamma-protein phosphatase 2A PMID: 17967874

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome, centromere.
  • 蛋白家族:
    Phosphatase 2A regulatory subunit B56 family
  • 組織特異性:
    Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver.
  • 數據庫鏈接:

    HGNC: 9311

    OMIM: 601645

    KEGG: hsa:5527

    STRING: 9606.ENSP00000412324

    UniGene: Hs.368264



主站蜘蛛池模板: 一二三四区无产乱码1000集| 秋霞无码久久久精品交换| 亚洲性av网站| 欧美精品一区二区黄a片| 四虎精品成人免费视频| 国产精品无码日韩欧| 欧美国产日韩亚洲中文| 国产综合色在线精品| 韩国美女视频黄是免费| 男女车车的车车网站w98免费| 精品无码一区在线观看| 奇米精品视频一区二区三区| 久久久久免费看成人影片| 精品国产肉丝袜久久| 啪啪无码人妻丰满熟妇| 无码日韩人妻精品久久| 日韩精品人涩人| 国内精品伊人久久久久av影院 | 国产伦精品免编号公布| 美女又黄又免费的视频| 免费看成人aa片无码视频| 好男人www社区视频在线资源| 国产精品天干在线观看| 国产欧美一区二区精品久久久| 国产男女无遮挡猛进猛出| 中文字幕人妻被公上司喝醉| 天天爽天天爽天天片a| 少妇的肉体在线观看| 中文无码成人免费视频在线观看| 国产亚洲精品久久久久久无| 亚洲国产精品隔壁老王| 少妇被躁爽到高潮无码久久 | 国产露脸150部国语对白| 美女张开腿让人桶| 亚洲性色av性色在线观看| 欧美天天综合色影久久精品| 国产一区二区女内射| 国产精品午夜福利麻豆| 亚洲风影视传媒有限公司辽宁| 动漫av纯肉无码av在线播放| 免费高清av一区二区三区|