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PPP2R1A Antibody

  • 中文名稱:
    PPP2R1A兔多克隆抗體
  • 貨號:
    CSB-PA018562GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    2AAA_HUMAN antibody; 6330556D22Rik antibody; Alpha isoform of regulatory subunit A; protein phosphatase antibody; DKFZp470L0914 antibody; Medium tumor antigen-associated 61 kDa protein antibody; MGC128399 antibody; MGC786 antibody; MGC83000 antibody; MGC95083 antibody; PP2A Aalpha antibody; PP2A antibody; PP2A subunit A isoform PR65-alpha antibody; PP2A subunit A isoform R1-alpha antibody; PP2A; subunit A; PR65-alpha isoform antibody; PP2A; subunit A; R1-alpha isoform antibody; PP2AAALPHA antibody; Ppp2r1a antibody; ppp2r1a-b antibody; PR65 antibody; PR65-alpha antibody; PR65A antibody; Protein phosphatase 2 (formerly 2A); regulatory subunit A (PR 65); alpha isoform antibody; Protein phosphatase 2 (Formerly 2A); regulatory subunit A (PR 65); alpha isoform; isoform CRA_a antibody; Protein phosphatase 2 (formerly 2A); regulatory subunit A; antibody; Protein phosphatase 2 regulatory subunit A alpha antibody; Protein phosphatase 2; 65-KD regulatory subunit A; alpha antibody; Protein phosphatase 2; regulatory subunit A; alpha isoform antibody; Protein phosphatase 2; structural/regulatory subunit A; alpha; PPP2R1A antibody; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PPP2R1A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis.
  • 基因功能參考文獻:
    1. PP2A controls mitotic exit through EG5 dephosphorylation. PMID: 28487562
    2. Total PP2A activity and PPP2R1A-associated PP2Ac activity were significantly increased in cells overexpressing PPP2R1A-WT. In addition, overexpression of PPP2R1A-WT increased cell proliferation in vitro and tumor growth in vivo PMID: 27272709
    3. PPP2R1A mutations occur in a subset of gastrointestinal stromal tumors and are associated with a high malignant potential that leads to decreased disease-free survival and overall survival PMID: 27469332
    4. Results demonstrated that the promotive effect of eEF-2K on glycolysis resulted from the kinase-mediated restriction of synthesis of the protein phosphatase 2A-A (PP2A-A). PMID: 27181208
    5. PPP2R1A mutation is associated with endometrial carcinoma progression and abdominopelvic metastasis. PMID: 27348297
    6. PPP2R1A mutations affect PP2A function and oncogenic signaling, illuminating the genetic basis for serous EC development. PMID: 27485451
    7. PR65A phosphorylation regulates PP2A complex signaling. PMID: 24465463
    8. Our results suggest that IH-induced ROS generation increases PP2A activation and subsequently downregulates ERK1/2 activation, which results in inhibition of PC12 cell proliferation through G0/G1 phase arrest and NGF-induced neuronal differentiation. PMID: 24885237
    9. The two functional variants in PPP2R1A and PPP2R5E and their combinations are associated with lung cancer risk in the Chinese. PMID: 24204789
    10. Partial unfolding of PR65/A impacts catalysis by altering the proximity of bound catalytic subunit and substrate. PMID: 24120762
    11. For PPP2R1A, a heterozygous, somatic mutation (c.771G>T, p.W257C) was identified in 1 out of 37 patients (2.7%) with primary ovarian endometrioid carcinoma. PMID: 23588898
    12. gene transcription of PPP2R1A regulated by the polymorphism and methylation in the promoter region PMID: 23555712
    13. This study indicates that the PPP2R1A mutation occurs at a lower frequency compared to other gynecological malignancies, irrespective of the histological subtype PMID: 23267135
    14. the frequent mutation of PPP2R1A in the serous type of uterine cancer, a low frequency of mutation in endometrioid endometrial cancer and absence of mutation in uterine carcinosarcoma. PMID: 21882256
    15. Our findings suggest that functional genetic variants in the proximal promoter of the PP2A-Aalpha gene and their haplotypes are critical in the regulation of transcriptional activation. PMID: 21889517
    16. identified somatic missense mutations in 40.8% of high-grade serous endometrial tumours and 5% of endometrial endometrioid carcinomas; mutations identified in ovarian tumours at lower frequencies;no mutations found in high- or low-grade serous carcinoma PMID: 21381030
    17. PPP2R1A somatic mutations occur in certain types of uterine and ovarian neoplastic lesions, especially uterine serous carcinomas PMID: 21435433
    18. PP2A-mediated dephosphorylation of Carma1 is a critical step to limit T-cell activation and effector cytokine production. PMID: 21157432
    19. genes mutated in ovarian clear cell carcinoma(OCCC);data suggest PPP2R1A functions as an oncogene and ARID1A as tumor-suppressor gene; in 42 OCCCs, 7% had mutations in PPP2R1A and 57% in ARID1A; suggests aberrant chromatin remodeling contributes to OCCC PMID: 20826764
    20. Data show that upon hypoxia, the TGF-beta-induced phosphorylation of Smad3 was inhibited, although Smad2 remained phosphorylated, and Smad3 was dephosphorylated by PP2A. PMID: 19951945
    21. PP2A-A alpha transcriptional regulation is mediated by multiple factors including AP-2alpha, CREB, ETS-1, and SP-1 PMID: 19750005
    22. Data show that DSB promote PP2A to associate with Ku 70 and Ku 86. PMID: 19794960
    23. PP2A-A has a role in the failure of beta1 integrin dephosphorylation at threonines 788 and 789 in tumor cell lines PMID: 14532964
    24. PP2A-mediated dephosphorylation of BCL-2 is required to protect BCL-2 from proteasome-dependent degradation, affecting resistance to ER stress PMID: 16717086
    25. dysfunction of E-cadherin due to its endocytosis may occur in some proportion of human breast carcinomas in which the PP2A-A protein is lost or significantly reduced PMID: 16930554
    26. protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator is regulated by heptad repeats, which are targeted by HTLV-I tax PMID: 17314097
    27. The results of these experiments indicate that the HSF2 region comprising amino acids 343-363 is important for A subunit interaction. PMID: 17688198

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  • 相關疾病:
    Mental retardation, autosomal dominant 36 (MRD36)
  • 亞細胞定位:
    Cytoplasm. Nucleus. Chromosome, centromere. Lateral cell membrane. Cell projection, dendrite.
  • 蛋白家族:
    Phosphatase 2A regulatory subunit A family
  • 數據庫鏈接:

    HGNC: 9302

    OMIM: 605983

    KEGG: hsa:5518

    STRING: 9606.ENSP00000324804

    UniGene: Hs.467192



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