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PPP1R3B Antibody

  • 中文名稱：
    PPP1R3B兔多克隆抗體
  • 貨號：
    CSB-PA769802LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: PPP1R3B antibody at 6µg/ml + Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 33 kDa
      Observed band size: 33 kDa
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA769802LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA769802LA01HU at dilution of 1:100
    • Western Blot
      Positive WB detected in: Rat heart tissue
      All lanes: PPP1R3B antibody at 2.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 33 kDa
      Observed band size: 33 kDa
  • 其他：

產品詳情

  • 產品描述：

    The PPP1R3B polyclonal antibody is produced in rabbits using recombinant human protein phosphatase 1 regulatory subunit 3B protein (1-285aa) as an immunogen. Protein G affinity chromatography was used to purify the antibody, achieving a purity level exceeding 95%, ensuring high quality and freedom from impurities that may interfere with experimental results.

    This PPP1R3B antibody is capable of detecting PPP1R3B protein in human, mouse, and rat samples. It has been extensively tested in various applications, including ELISA, WB, and IHC, for the qualitative and quantitative detection of PPP1R3B protein, as well as the determination of the presence and size and detection of localization and expression levels of this protein.

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PPP1R3B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    FLJ14005 antibody; FLJ34675 antibody; GL antibody; Hepatic glycogen targeting protein phosphatase 1 regulatory subunit GL antibody; Hepatic glycogen targeting subunit G(L) antibody; Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL antibody; PP1 subunit R4 antibody; Ppp1r3b antibody; PPP1R4 antibody; PPR3B_HUMAN antibody; Protein phosphatase 1 regulatory (inhibitor) subunit 3B antibody; Protein phosphatase 1 regulatory subunit 3B antibody; Protein phosphatase 1 regulatory subunit 4 antibody; Protein phosphatase 1 subunit 4 antibody; Protein phosphatase 1 subunit GL antibody; PTG antibody; R4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Protein phosphatase 1 regulatory subunit 3B protein (1-285AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PPP1R3B Antibody (CSB-PA769802LA01HU)，的標記方式是Non-conjugated。對于PPP1R3B Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA769802LB01HU PPP1R3B Antibody, HRP conjugated ELISA
    FITC CSB-PA769802LC01HU PPP1R3B Antibody, FITC conjugated
    Biotin CSB-PA769802LD01HU PPP1R3B Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes.
  • 基因功能參考文獻：
    1. These observations are consistent with the notion that the minor allele of rs4841132 promotes a mild form of hepatic glycogenosis that is associated with hepatic injury PMID: 29266543
    2. rs9987289 A-allele was associated with plasma lactate in European-Americans but not in African-Americans. PMID: 26433129
    3. Among Mexicans, the PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), and GCKR (rs780094) polymorphisms may be associated with a greater risk of chronic liver disease among overweight adults. PMID: 27752939
    4. A novel role for PTG in protecting hepatocellular carcinoma cells from metabolic stress, in part by regulating oxidative stress and autophagy. PMID: 26182369
    5. Some, but not all, associations between variants in NCAN, lysophospholipase-like 1, GCKR, and PPP1R3B with hepatic steatosis (with and without increased ALT level) were significant within subpopulations. PMID: 23416328
    6. Data indicate that genetic polymorphisms of the PPP1R3B gene may contribute to variations in plasma lipids and C-reactive protein (CRP) levels among Chinese Han individuals. PMID: 23343124
    7. Results suggest that in cultured human myotubes, glycogen-targeting PP1 (protein phosphatase 1) subunit G(L) (coded for by the PPP1R3B gene) is expressed as in muscle tissue and is unresponsive to glucose or insulin, as are G(M) and PTG genes. PMID: 17555403

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  • 組織特異性：
    Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only moderate levels in liver and heart. Weak expr
  • 數據庫鏈接：

    HGNC: 14942

    OMIM: 610541

    KEGG: hsa:79660

    STRING: 9606.ENSP00000308318

    UniGene: Hs.458513



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