在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PPP1R16B Antibody

PPP1R16B Antibody

  • 中文名稱：
    PPP1R16B兔多克隆抗體
  • 貨號(hào)：
    CSB-PA008661
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PPP1R16B
  • 別名：
    ANKRD4 antibody; Ankyrin repeat domain containing protein 4 antibody; ankyrin repeat domain protein 4 antibody; Ankyrin repeat domain-containing protein 4 antibody; CAAX box protein TIMAP antibody; hTIMAP antibody; KIAA0823 antibody; PP16B_HUMAN antibody; PPP1R16B antibody; Protein phosphatase 1 regulatory inhibitor subunit 16B antibody; protein phosphatase 1, regulatory (inhibitor) subunit 16B antibody; TGF beta inhibited membrane associated protein antibody; TGF-beta-inhibited membrane-associated protein antibody; TIMAP antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human TIMAP.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation. Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the dephosphorylation of EEF1A1.
  • 基因功能參考文獻(xiàn)：
    1. TIMAP is the versatile protein phosphatase 1 regulator in endothelial cells. (Review) PMID: 29140585
    2. NF2 localizes in nucleus when Ser518 is not phosphorylated, while phosphorylated form is present in cytoplasm and plasma membrane. Data suggest that binding of NF2 to TIMAP and EBP50 is critical in nuclear localization of NF2. (NF2 = neurofibromin 2; TIMAP = TGF-beta-inhibited membrane-associated protein; EBP50 = Ezrin-Radixin-Mosein binding phosphoprotein 50) PMID: 27871951
    3. phosphorylation of TIMAP on Ser331 by PKC represents a new mechanism of endothelial barrier regulation, through the inhibition of phospho-ERM dephosphorylation PMID: 27939168
    4. Results indicate that PKC-phosphorylated ECE-1 is a TIMAP-PP1c substrate and this phosphatase complex has an important role in endothelin-1 production of EC through the regulation of ECE-1 activity. PMID: 26806547
    5. ROCK phosphorylated eEF1A1 is a novel substrate for TIMAP-PP1 underlining the complex regulatory role of TIMAP in the endothelium. PMID: 26497934
    6. TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells. PMID: 25007873
    7. These data confirmed the barrier-protective role of TIMAP PMID: 21907835
    8. Data suggest that double-thiophosphorylation of TIMAP has minor effect on its binding ability to PP1c, but considerably attenuates its inhibitory effect on the activity of PP1c. PMID: 21466834
    9. TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells. PMID: 12055102
    10. involvement of TIMAP in PKA-mediated moesin dephosphorylation and the importance of this dephosphorylation in TIMAP-mediated endothelial cell barrier protection PMID: 18586956

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane. Cell membrane; Lipid-anchor. Nucleus. Cell projection.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 15850

    OMIM: 613275

    KEGG: hsa:26051

    STRING: 9606.ENSP00000299824

    UniGene: Hs.45719



主站蜘蛛池模板： 欧美日韩欧美| 欧美成人午夜免费影院手机在线看| 男女下面一进一出无遮挡| 中国内地毛片免费高清| 国产熟妇勾子乱视频| 亚洲午夜无码久久久久小说| 国内精品2020情侣视频| 国语自产偷拍精品视频偷| 精品国产av色一区二区深夜久久| 综合激情丁香久久狠狠| 少妇高潮惨叫久久久久电影| 无码午夜人妻一区二区三区不卡视频| 播放男人添女人下边视频| 2019最新久久久视频精品| 亚洲最大无码中文字幕网站| 精品国产三级a∨在线欧美| 国产精品美女一区二区视频| 国产av国内精品jk制服| 体内射精日本视频免费看| 青青草视频在线观看| 久久高清内射无套| 国产亚洲精品美女在线| 中文字幕 亚洲精品 第1页 | 中文字幕一区二区人妻电影| 久久久久四虎精品免费入口| 一本加勒比hezyo无码专区| 无码av波多野结衣| 狠狠色成人一区二区三区| 久久www成人免费直播| 国产佗精品一区二区三区| 少妇内射视频播放舔大片| 综合久久—本道中文字幕| 无码高潮少妇毛多水多水| 欧美性插b在线视频网站| 久久精品国产第一区二区三区| 亚洲欧美日韩国产自偷| 成年无码av片| 色婷婷五月综合久久| 琪琪午夜理论片福利在线观看| 国产精品区免费视频| 成人免费无遮挡无码黄漫视频|