在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PPP1CC Antibody, HRP conjugated

  • 中文名稱:
    PPP1CC兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA018505LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PPP1CC Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    PP 1G antibody; PP-1G antibody; PP1C antibody; PP1G antibody; PP1G_HUMAN antibody; PP1gamma antibody; PPP 1G antibody; PPP1CC antibody; PPP1G antibody; Protein phosphatase 1; catalytic subunit; gamma isozyme antibody; Protein phosphatase 1C catalytic subunit antibody; Serine/threonine phosphatase 1 gamma antibody; Serine/threonine protein phosphatase PP1 gamma catalytic subunit antibody; Serine/threonine-protein phosphatase PP1-gamma catalytic subunit antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Serine/threonine-protein phosphatase PP1-gamma catalytic subunit protein (151-323AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective.
  • 基因功能參考文獻:
    1. Here the authors show how Ki-67 and RepoMan form mitotic exit phosphatases by recruiting PP1, how they distinguish between distinct PP1 isoforms and how the assembly of these two holoenzymes are dynamically regulated by Aurora B kinase during mitosis. PMID: 27572260
    2. Data suggest that PPP1CC catalyzes hydrolysis of an assortment of substrates (aryl methylphosphonates, fluorophosphate esters, phosphorothioate esters, phosphodiesters); conservative mutation of R221 to K results in a mutant that is more effective catalyst toward monoanionic substrates; PPP1CC does not catalyze the hydrolysis of a sulfate ester, which is unexpected. PMID: 28678475
    3. PP1gamma is upregulated in hepatocellular carcinoma (HCC) cell lines and HCC specimens and promotes cancer cell proliferation through regulation of p53. High expression of PP1gamma in HCC cells contributed to doxorubicin resistance. PMID: 27921263
    4. knock-down of PP1gamma alleviates glioma proliferation by reducing p65 transportation into the nucleus. PMID: 26936744
    5. PP1gamma may be a novel target of the HPV-16 oncoproteins and indicate that it might be a potential novel biomarker for HPV-16 induced malignancy. PMID: 25886518
    6. Although no obvious defects in the progression of mitosis were observed, the timing of dephosphorylation of the mutant Ki67 in anaphase was delayed, indicating that Ki67 itself is one of the substrates of PP1gamma-Ki67. PMID: 25012651
    7. the lipin-1 N-terminal domain is important for its catalytic activity, nuclear localization, and binding to PP-1cgamma PMID: 24558042
    8. Protein phosphatase 1gamma promotes the alternative splicing of CaMKIIdelta through its interaction with alternative splice factor. PMID: 24196533
    9. When the Px(T)PxR motif is deleted or mutated via insertion of a phosphorylation site mimic (T311D), PP-1c fails to bind to all three ASPP proteins, ASPP1, ASPP2 and iASPP. PMID: 23088536
    10. Depletion of PP1gamma enhances the localization of the SMN complex and snRNPs to Cajal bodies. PMID: 22454514
    11. NUAK1 and PPP1CC are identified as positional candidate loci for skeletal muscle strength phenotypes. PMID: 21750233
    12. The counteracting Nek2A and PP1gamma activities on the centrosome linker are controlled by Plk1. PMID: 21723128
    13. The ataxia telangiectasia, mutated and Rad3-related-Chk1 axis regulates H3-pThr 11 dephosphorylation on DNA damage, at least in part by the activation of PP1gamma through Chk1-dependent inhibition of cyclin dependent kinases. PMID: 20948546
    14. gamma isoform of the human protein phosphatase-1 catalytic subunit (PP1c gamma) as a high affinity in vitro target of phosphatidic acid PMID: 11856740
    15. Nek2.PP1C complex is regulated by Inh2 via inhibition of phosphatase activity to initiate centrosome separation PMID: 12221103
    16. Tat might function as a nuclear regulator of PP1 and interaction of Tat with PP1 is critical for activation of HIV-1 transcription by Tat PMID: 16131488
    17. analysis of novel phosphatidic acid (PA) binding region on PP1c gamma that contains a unique loop-strand structural fold responsible for the interaction with PA PMID: 16201749
    18. crystal structures of the cyanotoxins, motuporin (nodularin-V) and dihydromicrocystin-LA bound to human protein phosphatase-1c PMID: 16343532
    19. We demonstrate that interaction with NIPP1 mediates decreased PP1gamma activity in hypoxia, an event which may constitute an inherent part of the cellular oxygen-sensing machinery and may play a role in physiologic adaptation to hypoxia. PMID: 16826568
    20. Data show that URI and PP1gamma are components of an S6K1-regulated mitochondrial pathway dedicated to oppose sustained S6K1 survival signaling and to ensure that the threshold for apoptosis is set based on nutrient and growth factor availability. PMID: 17936702
    21. Results describe a specific intracellular pathway involving the activation of PP1cgamma to mediate the effects of confluence-induced beta-catenin dephosphorylation. PMID: 17996206
    22. PP1cgamma1 overexpression promotes VSMC survival by interfering with JNK1 and p53 phosphorylation cascades involved in apoptosis PMID: 18540044

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center.
  • 蛋白家族:
    PPP phosphatase family, PP-1 subfamily
  • 數據庫鏈接:

    HGNC: 9283

    OMIM: 176914

    KEGG: hsa:5501

    STRING: 9606.ENSP00000335084

    UniGene: Hs.79081



主站蜘蛛池模板: 国内精品伊人久久久久av影院| 欧美人与动交视频在线观看| 国产孩cao大人xxxx| а天堂中文最新版在线| 性欧美大战久久久久久久久 | 国产无套水多在线观看| av无码免费岛国动作片不卡| 久久婷婷五月国产色综合| 麻豆av传媒蜜桃天美传媒| 国产亚洲日韩在线aaaa| 欧美一区二区三区久久综| 伦埋琪琪电影院久久| 国精品人妻无码一区二区三区d3| 亚洲色无码专区一区| 狠狠色色综合网站| 97在线视频人妻无码| 国产免费一卡二卡三卡四卡| 一本清日本在线视频精品| 国产呻吟久久久久久久92| 亚洲久悠悠色悠在线播放| 色噜噜狠狠色综合网| 日亚韩在线无码一区二区三区 | 欧美顶级metart裸体全部自慰| 最新国产aⅴ精品无码| 在线天堂中文官网| 毛片免费视频肛交颜射免费视频| 久久综合给综合给久久| 免费视频好湿好紧好大好爽| 日本公妇乱偷中文字幕| 中文字幕精品一区二区精品| 人人澡人人曰人人摸看| 无码高潮少妇毛多水多水| 人人妻人人澡人人爽人人精品av| 99精品国产福利在线观看| 国产婷婷综合在线视频| 亚洲爆乳无码精品aaa片蜜桃| 国产色诱视频在线观看| 亚洲色欲色欲www成人网| 国产亚洲精品俞拍视频| 欧美孕妇乳喷奶水在线观看| 国产在线精品一区二区在线看|